Carcinoma renal que debuta como cuadro neurológico paraneoplásico

Hens, Manuel; Camacho, B. Sosa; Maestre, Amanda; González, V. Baena; Villegas, Irene Amat; M, Magaña Hernández

doi:10.1016/s0210-4806(08)73902-0

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Cerebellar signs and symptoms are not related to a metastatic disorder; instead, the mechanism of injury is autoimmune [1]. It can be secondary to any cancer, although the most common are gynecological and breast cancer, lung cancer, and Hodgkin’s lymphoma [2]. The neurologic symptoms may precede the diagnosis of cancer by several years [3].…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

et al. 2019

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Background Paraneoplastic cerebellar degeneration is usually associated with gynecological and breast cancer, lung cancer, and Hodgkin’s lymphoma. Renal cell carcinoma has rarely been described as an underlying malignancy in these cases. Case presentation We report the case of a 75 year-old woman who develop cerebellar ataxia following a respiratory viral infection. During investigation, around 1 year afterward, she noticed constitutional symptoms suggestive of malignancy. Renal carcinoma was found and the hypothesis of paraneoplastic cerebellar degeneration was considered. Conclusions As no specific antineuronal antibodies have been described in the setting of renal cell carcinoma, paraneoplastic cerebellar degeneration should be considered when the tumor is detected and other causes are excluded. Immunotherapy should be prescribed as soon as possible.

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Section: Introductionmentioning

confidence: 99%

“…The neurologic symptoms may precede the diagnosis of cancer by several years [3]. Hens et al, for example, reported a paraneoplastic cerebellar syndrome that began 6 years previous to the detection of a renal cell carcinoma [2].…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

et al. 2019

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A Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma

Ayas

Uncu

2021

Current Oncology

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Paraneoplastic cerebellar degeneration (PCD) is a rare neuroimmunological disease that may accompany tumors. In this article, we present a patient with progressive gait difficulty who was diagnosed with PCD and, in a rare comorbidity, with papillary thyroid carcinoma (PTC) following malignancy screening. A 46-year-old male patient reported having experienced poor balance for 2 years. A neurological examination revealed nystagmus, intention tremor, and ataxia, and anti-thyroid peroxidase and anti-thyroglobulin levels were found to be elevated. A brain MRI showed significant cerebellar atrophy in the superior vermis. Malignancy screening for PCD was performed, and thyroid ultrasonography revealed a nodule in the left lobe, while PET/CT detected elevated focal F-18 fluorodeoxyglucose uptake in the thyroid. Onconeuronal antibodies (anti-Hu, anti-Yo, anti-Ri, anti-amphiphysin, anti-Tr, anti-PPCA-2, anti-Ma, anti-CV-1, and anti-ANNA-3) were negative. Pathologic examination of the thyroid revealed PTC, for which the patient was treated with 0.4 g/kg intravenous immunoglobulin and referred to the medical oncology department. This case demonstrates that clinicians must be alert to the rare comorbidity of PCD and PTC.

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Carcinoma renal que debuta como cuadro neurológico paraneoplásico

Abstract: A progressive cerebellar syndrome could be the first manifestation of a renal cell carcinoma, even years before the first urologic symptoms. We must suspect an occult neoplasia in such patients.

Cited by 2 publications

References 17 publications

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

A Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma

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