Carcinoma of the vagina following cervical cancer

Kanbour, Anisa; Klionsky, Bernard; Murphy, Arthur I.

doi:10.1002/1097-0142(197411)34:5<1838::aid-cncr2820340537>3.0.co;2-b

Cited by 41 publications

(5 citation statements)

References 35 publications

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“…Such neoplasms have often in the past been regarded as residual or recurrent carcinoma. They are now recognized as a distinctive entity that may occur in various forms: (1) Following a total hysterectomy for in situ carcinoma of the cervix, as carcinoma in situ [5,6] or invasive carcinoma [7] of the vagina; (2) following radical hysterectomy for invasive carcinoma of the cervix, as carcinoma in situ or invasive carcinoma of the vagina [8]; and (3) following irradiation for invasive cervical carcinoma, as carcinoma in situ [9,10], invasive carcinoma [ 11,121, or sarcoma [ 131 of the vagina. This study is about a clinical analysis of a reasonably large number of such patients encountered in one institution and discusses their presentation, identification, and treatment.…”

Section: Introductionmentioning

confidence: 99%

Neoplasms of the vagina following cervical carcinoma

Choo

Anderson

1982

Gynecologic Oncology

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Neoplasm in the vagina which occurs following treatment of cervical carcinoma could represent a separate primary neoplasm, a "field" response to a common carcinogen, or be due to neoplastic transformation of tissue from previous radiation treatment. Fifty patients with a second neoplasm in the vagina were identified: 17 following total hysterectomy for carcinoma in situ of cervix; 4 following radical hysterectomy; and 29 following radiotherapy for invasive cervical carcinoma. Their clinical features, diagnosis, and treatment modalities are presented. Since vaginal neoplasm may occur long after treatment of the initial cervical carcinoma especially after previous radiotherapy, lifelong follow-up of all patients with cervical carcinoma is mandatory.

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Section: Introductionmentioning

confidence: 99%

Neoplasms of the vagina following cervical carcinoma

Choo

Anderson

1982

Gynecologic Oncology

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“…Frequently, women with squamous carcinoma of the vagina (SCAVA) have undergone prior hysterectomy. Patients with SCAVA may have been previously treated with surgery or radiation for in situ or invasive cervical neoplasia in 15-20% of cases (3)(4)(5) .…”

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confidence: 99%

Chemoradiation for primary invasive squamous carcinoma of the vagina

Dalrymple

Russell²,

Lee³

et al. 2004

Int J Gynecol Cancer

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ObjectiveTo report outcomes for patients with primary, invasive, squamous carcinoma of the vagina treated with chemoradiation.MethodsBetween 1986 and 1996, 14 patients were treated with primary therapy consisting of synchronous radiation and chemotherapy. Patients were judged not to be surgical candidates based on tumor size, location, and concerns related to urinary, bowel, or sexual function. Three patients were FIGO stage I, ten patients stage II, and one patient stage III. Radiation consisted of teletherapy alone (six patients) or in combination with intravaginal brachytherapy (eight patients). Total radiation dose ranged from 5700 to 7080 cGy (median 6300 cGy). Chemotherapy consisted of 5-fluorouracil alone (seven patients), or with cisplatin (six patients) or mitomycin-C (one patient).ResultsOne patient failed locally at 7 months and died of disease at 11 months. Four patients died of intercurrent illness (46, 92, 104, 109 months) and nine are alive and cancer-free 74–168 months after treatment (median 100 months). There were no vesicovaginal or enterovaginal fistulae.ConclusionsRadiation with synchronous chemotherapy is an effective treatment for squamous carcinoma of the vagina. Cancer control outcomes compare favorably with previously published results employing higher dose radiation as monotherapy.

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“…Although the number of all second cancers in patients after treatment for lower genital tract squamous cell carcinoma is not obviously increased (5)(6)(7), most studies demonstrated an increased risk of developing a new primary within the lower genital tract (2,3,6,(8)(9)(10)(11)(12). The prevalence of these tumors in these patients varies between 2.5 and 37% (8,(12)(13)(14)(15). In the study of Storm (7) the risk of developing second lower genital tract cancers in cervical carcinoma patients was 5 to 12 times higher, compared to the general population.…”

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confidence: 97%