Carcinoma of the uterine cervix stage III: A report of 311 cases

Hiilesmaa, Vilho; Vesterinen, E; Nieminen, U; Gröhn, Pentti

doi:10.1016/0090-8258(81)90101-3

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…Other studies, on the other hand, reported that 5-year OS of stage IIIA was less than stage IIIB. Hiilesmaa et al [ 2 ] reported that 5-year OS of stage IIIA and stage IIIB were 9% and 33%, respectively. Similar result was also reported by Montana et al [ 8 ], which showed that 5-year OS of stage IIIA was 26%, and stage IIIB was 35%.…”

Section: Discussionmentioning

confidence: 99%

“…For stage III cervical cancer, invasion of tumor to only the lower third of vagina is considered stage IIIA. However, extension to only the lower third of vagina but not the pelvic sidewall is the least common in stage III with no more than 5% of patients in this stage [ 2 3 4 5 ], and there are also limited studies of treatment outcomes in these patients. Some authors reported that stage IIIA had better treatment results than stage IIIB [ 6 7 ], whereas others showed the poorer overall survival (OS) of stage IIIA comparing with stage IIIB [ 2 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparing treatment outcomes of stage IIIB cervical cancer patients between those with and without lower third of vaginal invasion

Katanyoo

2017

J Gynecol Oncol

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ObjectiveTo evaluate treatment outcomes between stage IIIB cervical cancer with and without lower third of vaginal invasion (LTI) in terms of response to treatment and overall survival (OS).MethodsMatching one patient with LTI for 2 patients without LTI who had completed treatment between 1995 and 2012 were conducted by using treatment modalities (radiation therapy [RT] alone vs. concurrent chemoradiation therapy [CCRT]) and tumor histology (squamous cell carcinoma [SCC] vs. adenocarcinoma [ADC]). Treatment outcomes including complete response (CR) rate of RT/CCRT, patterns of treatment failure and survival outcomes were analyzed.ResultsOf 216 stage IIIB cervical cancer patients, 114 of them had no LTI and 72 had LTI. Most of the patients (83.8%) had tumor histology as SCC. The CR rates between stage IIIB without LTI and with LTI were 93.8% and 81.9% (p=0.009), and corresponding with disease progression at pelvis accounted for 18.2% and 34.4% (p=0.017), respectively. Distant metastasis was comparable between 2 groups of patients, 28.9% in patients without LTI and 29.5% in patients with LTI (p=0.988). The 2-year and 5-year OS of stage IIIB without LTI were 66.5% and 46.8% compared to stage IIIB with LTI which were 43.1% and 28.9% (p=0.004), respectively. For multivariable analysis, stage IIIB with LTI was only the influential factor on OS with hazard ratio (HR) of 1.63 (p=0.012).ConclusionStage IIIB cervical cancer patients with LTI have poorer treatment outcomes including response to treatment and survival outcomes than patients in the same stage without LTI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparing treatment outcomes of stage IIIB cervical cancer patients between those with and without lower third of vaginal invasion

Katanyoo

2017

J Gynecol Oncol

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“…The combined use of external beam and intracavitary radiation has been associated with a higher complication rate than either modality alone (2). There is some literature concerning RT for stage IIIB cervical cancer (3)(4)(5); however, scant data exist examining patients' outcomes relative to the application of aggressive RT (defined as the full use of external beam pelvic radiation with tandem and ovoids intracavitary brachytherapy) and nonaggressive RT. The most striking results yet obtained are those of Lanciano et al (6).…”

Section: Sirmentioning

confidence: 99%

Aggressive radiotherapy for stage IIIB cancer of the cervix, Helpful or harmful?

Ampil

Bell

1998

Acta Obstet Gynecol Scand

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Predisposing Factors, Clinical Features, Investigations: Radiation Urinary Tract Disease

Lupton¹

1989

The Causation and Clinical Management of Pelvic Radiation Disease

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Carcinoma of the uterine cervix stage III: A report of 311 cases

Cited by 12 publications

References 8 publications

Comparing treatment outcomes of stage IIIB cervical cancer patients between those with and without lower third of vaginal invasion

Comparing treatment outcomes of stage IIIB cervical cancer patients between those with and without lower third of vaginal invasion

Aggressive radiotherapy for stage IIIB cancer of the cervix, Helpful or harmful?

Predisposing Factors, Clinical Features, Investigations: Radiation Urinary Tract Disease

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