Carcinoma of the parathyroid gland: is it overdiagnosed?

McKeown, Peter P.; McGarity, William C.; Sewell, Charles W.

doi:10.1016/0002-9610(84)90110-7

Cited by 72 publications

(40 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The radiotherapy given is often not speci®ed, nor is the mode of evaluation, a fact that makes the evaluation dif®cult. There are, however, a few case reports that indicate positive effects of radiotherapy (6,10). Our patient was initially treated with intravenous pamidronate for 15 weeks before radiotherapy was started.…”

Section: Discussionmentioning

confidence: 93%

Positive effect of radiotherapy and surgery on hormonally active pulmonary metastases of primary parathyroid carcinoma

Rasmuson¹,

Kristoffersson²,

Boquist

2000

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Surgery is the primary treatment in recurrent or metastatic disease. Radiotherapy has been used as an adjuvant to control subclinical local disease but is otherwise considered ineffective. Design: We report on a patient with parathyroid carcinoma with hypercalcaemia and pulmonary metastases, treated with pamidronate and radiotherapy and later with surgery. Methods: The treatment was evaluated using serial analysis of serum parathyroid hormone (PTH) and calcium, clinical evaluation and chest radiographs. Results: Intravenous pamidronate alone had limited effect on hypercalcaemia. Following irradiation of the pulmonary lesions (34 Gy in ten fractions), serum levels of calcium and PTH decreased and pamidronate could be discontinued. The patient's general condition improved parallel to a radiological response. At clinical relapse 18 months following radiotherapy, the pulmonary metastases were resected and serum PTH was normalised. Conclusions:The results indicate that parathyroid carcinoma can be radiosensitive. Thus radiotherapy may be an alternative to palliate symptoms of hypercalcaemia in patients not suited for surgery.

show abstract

Section: Discussionmentioning

confidence: 93%

Positive effect of radiotherapy and surgery on hormonally active pulmonary metastases of primary parathyroid carcinoma

Rasmuson¹,

Kristoffersson²,

Boquist

2000

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…According to reports by authors in Japan and abroad, the cancer diagnosis rate following parathyroidectomy for hyperparathyroidism is 0.5-5.0% [1,2,[5][6][7], This rate is so low that, with the exception of very advanced cancer, definite cancer diagnosis is often difficult to make. We summarized the diagnosis criteria for parathy roid carcinoma reported by some pathologists [1,3,[5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Parathyroid Carcinoma in a Case of Chronic Renal Failure on Dialysis

et al. 1989

View full text Add to dashboard Cite

The combination of chronic renal failure plus parathyroid adenocarcinoma is very rare. A 53-year-old female had been on hemodialysis for chronic renal failure for 7 years. For 2 years she has had bilateral knee joint pain, hypercalcemia and an increased parathyroid hormone level. Swelling of parathyroid gland was diagnosed and it was excised. Histological examinations of the excised right lower parathyroid gland revealed adenocarcinoma and the left lower gland showed hyperplasia.

show abstract

“…As mentioned previously, patients who undergo a complete surgical resection at the time of initial surgery have a lower recurrence rate compared to patients that only undergo a simple parathyroidectomy [12,76,77]. Usually the recurrences occur approximately two to three years after initial treatment [76].…”

Section: Surgical Managementmentioning

confidence: 97%

“…Metastatic PC is a disease that spreads beyond the tissues adjacent to the involved parathyroid gland(s). PC most commonly metastasizes to regional lymph nodes and lungs, and it may involve other distant sites, such as liver, bone, pleura, pericardium, and pancreas [7,50,76,77].…”

Section: Stagingmentioning

confidence: 99%

Current Understanding and Management of Parathyroid Carcinoma

Arrangoiz¹

2017

JCTR

View full text Add to dashboard Cite

Parathyroid adenomas are a very common endocrine entity, whereas parathyroid carcinomas (PC) are extremely rare. With an estimated incidence of 0.015 per 100,000 population and an estimated prevalence of 0.005% in the United States, parathyroid cancer is one of the rarest of all human malignancies. PC is an extremely rare cause of primary hyperparathyroidism (PHPT). Men and women are equally affected, usually in the fourth or fifth decade of life. The exact etiology has not been identified, but mutations in the CDC73 gene appear to have a critical role in its pathogenesis. The morbidity and mortality of PC is secondary to the hypercalcemia resulting from tumor overproduction of PTH. The primary management objectives are complete removal of the cancer and prevention of recurrences. This review will talk about the epidemiology, etiology, clinical manifestations, and management of PC.

show abstract

Carcinoma of the parathyroid gland: is it overdiagnosed?

Cited by 72 publications

References 12 publications

Positive effect of radiotherapy and surgery on hormonally active pulmonary metastases of primary parathyroid carcinoma

Positive effect of radiotherapy and surgery on hormonally active pulmonary metastases of primary parathyroid carcinoma

Parathyroid Carcinoma in a Case of Chronic Renal Failure on Dialysis

Current Understanding and Management of Parathyroid Carcinoma

Contact Info

Product

Resources

About