Carcinoma of the Pancreas

Kiefer, Everett D.

doi:10.1001/archinte.1927.00130070004001

Cited by 34 publications

(5 citation statements)

References 7 publications

(2 reference statements)

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“…1) and good appetite were notable. Glycosuria, which was present in this case, was found in forty-three out of two hundred and one cases at all ages collected from various authors by Kiefer (1927); it was not noted in any of the other cases referred to in children. The duration of the disease in the other childhood cases has been described as several months, most of the cases only being under observation for the last few weeks; in this case the history would indicate that there was definite hepatic enlargement at the age of five months, and therefore the primary growth probably arose shortly after birth.…”

Section: Discussionmentioning

confidence: 43%

Primary carcinoma of the pancreas in an infant aged seven months

Corner¹

1943

Archives of Disease in Childhood

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Phvsician to Out-Patients, Bristol Children's Hospital Primary malignant disease of the pancreas in infancy and childhood is a rarity as indicated by the few cases reported in the literature.Lymphosarcoma was found in a new-born infant by L'Huillier (1904), and in a girl aged four years by Litten (quoted by Ewing, 1928). Todd (1818) reported a case of a girl aged fourteen years, who having been ill for some months with pyrexia and digestive disturbances, became deeply jaundiced and died. Post mortem, the pancreas appeared scirrhous, and the head of the gland was converted into a solid tumour mass which obstructed the common bile duct, causing gross distension of biliary and hepatic ducts. Rokitansky (1842) and Wedl (1866) both describe a scirrhous condition of the pancreas in new-born infants, but in Wedl's case the mother had syphilis, so that the condition was probably syphilitic and not malignant. Battersby (1844) reperts a case of carcinoma in a fourteen-year-old child, and Herringham (1894) in a two-year-old child, but no details of the case are given and in none of these five cases is there any histological confirmation of malignancy.There are five recorded cases of pancreatic primary carcinema in childhcod in which histological evidence of malignancy has teen obtained. Bohn's case (1885) was an infant aged six months who was found to has-e an abdominal tumour and developed jaundice six weeks before death. Microscopy of the tumcur. which was situated in the head of the pancreas, showed that it had a finely meshed alx-eolar structure in the spaces of which were clusters of medium-sized cubical epithelial cells. There were secondary deposits in the lix er and in the glands at the portal fissure.Kuhn (1887) reported a case in a girl aged two years. This child had been ill for about nine months and then developed oedema of her legs and diarrhoea. An enlargement of the liver was found and she died from pneumonia. Post mortem the pancreas was found to be almost completely' replaced bv a reddish tumour, and there were secondarv nedules in the lix-er. Histology showed that the tumour was a cylindrical celled adeno-carcinoma. Simon's (1889) case was a thirteen-year-old boy, whose symptcms were anorexia and diarrhoea w-ith jaundice eight weeks before death. The whole gland w ith the exception of a small part of the tail, was inxolxed in a tumour mass, the histology of which was identical with Kuhn's case. Bandelier (1896) February 26, 1939. Both parents were healthy, and she had a sister aged two years w,ho was alive and well. She was breast-fed for three months and then weaned on to a cows' milk and w ater mixture. Her abdomen had seemed large since birth, but at the age of five months the mother complained that it was increasing rapidly in size and seemed very hard. Bowels were usually constipated, appetite was good but the child had alwavs had a good deal of flatulence and magnesia was given regularly. She was admitted to Bristol Children's

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Section: Discussionmentioning

confidence: 43%

Primary carcinoma of the pancreas in an infant aged seven months

Corner¹

1943

Archives of Disease in Childhood

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“…Liposarcoma, leiomyosarcoma and malignant fibrous histiocytoma are identified as other types of malignant pancreatic mesenchymal tumors ( 6 ). According to the literature, the first surgical excision of a pancreatic spindle cell sarcoma was likely performed by Trendelenburg in 1882, and Segre provided the first pathological descriptions of two cases of pancreatic primary sarcoma ( 7 , 8 ). Primary pancreatic tumors are relatively large at presentation.…”

Section: Discussionmentioning

confidence: 99%

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

Ali¹,

Seerwan

Ali³

et al. 2023

Med Int

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Synovial sarcoma is a mesenchymal spindle cell tumor. Primary pancreatic sarcomas are extremely rare. the present study describes a rare case of synovial sarcoma in the head of the pancreas. a 35-year-old male presented with left upper quadrant abdominal pain. an endoscopic ultrasound examination revealed a complex solid-cystic lesion in the pancreatic head. He had undergone pancreaticoduodenectomy (Whipple procedure). a histological examination yielded negative results for aE1/aE3, CD10, S100, CD34, desmin, smooth muscle actin, β-catenin, CD117, HMB45, chromogranin and synaptophysin. However, the results were positive for tlEI and vimentin, which is consistent with synovial sarcoma. Synovial sarcoma is a soft tissue malignant tumor. Primary pancreatic sarcomas frequently present as large, high-grade tumors in the pancreatic head. Histologically, there are several types of synovial sarcoma, such as monophasic, biphasic and poorly differentiated. a histological examination is necessary for the diagnosis as the imaging findings are not specifically suggestive of synovial sarcoma. the preferred course of treatment is complete resection with wide margins, followed by adjuvant chemotherapy and/or radiotherapy. Primary mesenchymal tumors of the pancreas are extremely uncommon. as a result, a diagnosis requires careful evaluation. Surgical resection is the main modality of treatment.

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“…In particular, very few cases have been reported about pancreatic cancer metastasizing to testicular and paratesticular tissues. Kiefer[ 3 ] first described epididymal spread originating from primary pancreatic cancer, which was incidentally discovered during autopsy in 1927[ 3 ]. To date, less than 30 cases have been reported including 1from China[ 4 ], 2from South Korea[ 5 , 6 ], 10from Japan[ 7 ], 6from the United States[ 8 - 12 ], and the other 5from European countries[ 13 - 17 ].…”

Section: Discussionmentioning

confidence: 99%

Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

Zhang¹,

Ma²,

Gao³

et al. 2021

WJCC

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BACKGROUND Metastases from pancreas or ampullary malignancies are common, but the spread to testicle and paratesticular tissue is exceedingly rare. To the best of our knowledge, fewer than 30 cases have been reported in the literature. More rarely, metastasis to tunica vaginalis testis occurs without involvement of the testes and epididymis. CASE SUMMARY A 65-year-old male who complained of painless swelling of the left scrotum for over 1 wk was referred to the Department of Urology. Scrotal ultrasound showed left testicular hydrocele with paratesticular masses. Chest computed tomography revealed lung metastasis and enlarged left supraclavicular lymph node.The blood tumor markersalpha-fetoprotein, human chorionic gonadotropin, and serum lactate dehydrogenase were withinnormal limits.The preoperative diagnosis was left testicular tumor with lung metastasis. Then radical orchidectomy of the left testicle and high ligation of the spermatic cord were performed, and postoperative histopathology suggested metastatic tumors that was confirmed by an abdominal computed tomographic scan. The positive computed tomography findings, in conjunction with the expression of cytokeratin 7 (CK7), CK20, CK5/6, and absence of expression of Wilms’ tumor suppressor gene 1, calretinin, melanocyte, prostate-specific antigen, thyroid transcription factor-1, GATA binding protein 3, caudal type homeobox 2, and napsinA supported the diagnosis of pancreatic adenocarcinoma. The outcome of this patient was unsatisfactory, and he died 3 mo later. CONCLUSION This case suggests that pancreatic metastatic carcinoma must be considered in the differential diagnosis of scrotal enlargement. The advanced age of the patient wassuggestive of a secondary testicular tumor.In addition, careful physical examination and ultrasonography as well as radiological examination have become a standard modality.

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Carcinoma of the Pancreas

Cited by 34 publications

References 7 publications

Primary carcinoma of the pancreas in an infant aged seven months

Primary carcinoma of the pancreas in an infant aged seven months

Primary pancreatic synovial sarcoma: Report of a rare case and review of the literature

Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

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