Carcinoma of the Œsophagus After Gastric Surgery

Shearman, DavidJ.C.; Finlayson, N. D. C.; Arnott, S.J.; Pearson, J. Gareth

doi:10.1016/s0140-6736(70)91623-5

Cited by 41 publications

(18 citation statements)

References 4 publications

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“…Our analysis did not confirm an increase in esophageal cancer, and the risk of colorectal cancer was decreased in postgastrectomy patients, contrary to the observations of others (Shearman et al, 1970;McLean Ross et al, 1982;Bundred et a/., 1985;Caygill et al, 1987;Mullan et al, 1989). Also, we found no increase in small-intestine cancer.…”

Section: Discussioncontrasting

confidence: 99%

Occurrence of non‐gastric cancer in the digestive tract after remote partial gastrectomy: Analysis of an Amsterdam cohort

Tersmette

Offerhaus

Giardiello

et al. 1990

Intl Journal of Cancer

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If peptic ulcer surgery favors the formation of carcinogenic N-nitroso compounds in the gastric remnant, an increased risk of cancer at sites in the gastrointestinal tract distant from the stomach might be predicted. To estimate the risk of carcinomas in the digestive tract, other than the stomach, occurring after partial gastrectomy, we analyzed an Amsterdam cohort of 2,633 post-gastrectomy patients operated on for benign disease between 1931 and 1960. Mortality in the study population was compared with the general Dutch population through person-year analysis. An excess mortality of biliary tract cancer (O/E:2.64; CL:1.32-4.72; p less than 0.01) and pancreatic cancer (O/E:1.65; CL:1.06-2.44; p less than 0.05) was found in males more than 5 years after surgery; females showed only an increased risk of pancreatic cancer in the first 5 years postoperatively (O/E:15.33; CL:1.85-55.43; p less than 0.01), probably due to misdiagnosis. All other non-gastric sites of the digestive tract carried no increased risk for cancer. In males, mortality due to colorectal cancer more than 5 years post-operatively was significantly decreased (O/E:0.58; CL 0.34-0.92; p less than 0.01). The excess mortality of biliary-tract and pancreatic cancer in males, which increases with the duration of post-operative interval, is consistent with a dose-response phenomenon. This study therefore supports the hypothesis that carcinogens are not only locally activated in the gastric remnant, but are hepatically excreted and initiate cancer in the biliary tree and pancreatic duct. Further exploration of this mechanism of carcinogenesis is warranted, since it may also explain the pathogenesis of pancreatic and biliary cancers in patients without gastrectomy.

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Section: Discussioncontrasting

confidence: 99%

Occurrence of non‐gastric cancer in the digestive tract after remote partial gastrectomy: Analysis of an Amsterdam cohort

Tersmette

Offerhaus

Giardiello

et al. 1990

Intl Journal of Cancer

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“…In addition this incidence is higher than for the other frequently quoted associations of achalasia (2%) and hiatus hernia. It was exceeded only by the occurrence of previous gastric surgery (Shearman et al, 1970). However, it should be noted that in two of our cases with upper oesophageal cancer, radiotherapy to the neck had been given previously.…”

Section: Resultsmentioning

confidence: 99%

“…In oesophageal carcinoma, the wide variation in the incidence of the disease'in different countries has been interpreted as due to differing exposure to environmental factors such as smoking, alcohol, tobacco and betal nut chewing. In some groups of patients with oesophageal cancer, associations with achalasia (Bockus, 1963) and hiatus hernia (Smithers, 1955) (Shearman et al, 1970) an association between oesophageal cancer and previous gastric operation was noted. In the present paper a further association with thyToid disorder is described.…”

mentioning

confidence: 99%

The Association of Squamous Oesophageal Cancer and Thyroid Disease

Arnott¹,

Pearson²,

Finlayson³

et al. 1971

Br J Cancer

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“…It has been suggested that patients who have undergone gastrectomy may be more susceptible to later development of esophageal cancer (Shearman et al, 1970;Caygill et al, 1987) particularly in the lower part (Maeta et al, 1986). Our findings do not substantiate these results.…”

Section: Cancer In Digestive Organsmentioning

confidence: 99%

The risk of cancer at all sites following gastric operation for benign disease. A cohort study of 4,224 patients

Eide

Viste

Andersen

et al. 1991

Intl Journal of Cancer

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This report represents the results of a historical cohort analysis of 3,360 males and 864 females who had a gastric resection or gastroenterostomy for benign disease between 1990 and 1969. Within the period 1970 to 1988 the cohort was cross-checked with the data files at the Cancer Registry of Norway to identify the patients in whom cancer had been diagnosed. When analyzed according to cancer sites, increased risk was recorded for the oropharynx, stomach, colon, pancreas, liver, biliary tract, larynx, lungs, urinary bladder and non--melanomatous cancers of the skin in males. In females, increased risk was only observed for the oropharynx, but was close to a statistically significant level also for cancer of the stomach. A lower number of tumors of the central nervous system than expected was observed in both males and females. The increased risk of cancer of the lungs, larynx and urinary bladder in males can be regarded as evidence of the high prevalence of smokers in the cohort. We suggest that the increased risk of cancer of digestive organs is mainly related to life-style factors, particularly tobacco-specific nitrosamines whose effect is enhanced by surgical sequelae.

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Carcinoma of the Œsophagus After Gastric Surgery

Cited by 41 publications

References 4 publications

Occurrence of non‐gastric cancer in the digestive tract after remote partial gastrectomy: Analysis of an Amsterdam cohort

Occurrence of non‐gastric cancer in the digestive tract after remote partial gastrectomy: Analysis of an Amsterdam cohort

The Association of Squamous Oesophageal Cancer and Thyroid Disease

The risk of cancer at all sites following gastric operation for benign disease. A cohort study of 4,224 patients

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