Carcinoma of the maxillary antrum: Surgery or radiation therapy?

Elective neck irradiation in locally advanced squamous cell carcinoma of the maxillary sinus: a review

“…The combination of surgery and RT has shown 5-year local control above 50% and 5-year survival of 40-60% (Bush and Bagshaw 1982;Sakai et al 1983;St.-Pierre and Baker 1983;Knegt et al 1985;Tsujii et al 1986). This approach seems historically superior to RT alone, or surgery for which overall survival of 20-40% (Amendola et al 1981;Bush and Bagshaw 1982;Frich 1982;Wang 1997) and 20-30% (Amendola et al 1981;St.-Pierre and Baker 1983) have been reported, respectively.…”

Elective ipsilateral neck irradiation of patients with locally advanced maxillary sinus carcinoma

“…Although results obtained with these methods ranged between 30 -50% in reports published in the 1960s and 1970s, [3][4][5][6] recent results for combined treatment were Ͼ50% for 5-year local control and between 40 -60% for 5-year survival. [7][8][9][10][11] This appears to be an improvement over either local recurrence free survival or survival of 20 -40% obtained with RT alone 7,[12][13][14] or 20 -30% for survival after surgery only. 10,12 For RT, there are a number of questions left unanswered because a vast majority of studies covered long time periods and therefore included patients diagnosed and treated with different techniques/ methods.…”

“…[7][8][9][10][11] This appears to be an improvement over either local recurrence free survival or survival of 20 -40% obtained with RT alone 7,[12][13][14] or 20 -30% for survival after surgery only. 10,12 For RT, there are a number of questions left unanswered because a vast majority of studies covered long time periods and therefore included patients diagnosed and treated with different techniques/ methods. One of the questions frequently asked, but to our knowl-edge not well answered as of yet, is the type of treatment to the neck in patients with locally advanced tumors (T3 or T4) but no detectable regional (neck) lymph node metastases (N0).…”

Surgery in the Multimodality Treatment of Sinonasal Malignancies

“…Local control rates ranging from 14% to 53% have been reported. [24][25][26][27][28][29] However, many studies are marked by selection bias, and patients treated nonsurgically more often have locally advanced disease or are considered inoperable (Table 7). 23,28,[30][31][32][33] The use of induction chemotherapy for sinonasal squamous cell carcinomas has not been associated with improved local control or a survival advantage.…”