Carcinoma of the gallbladder

Koo, Jarley; Wong, John; Cheng, F. C. Y.; Ong, G. B.

doi:10.1002/bjs.1800680307

Cited by 37 publications

(10 citation statements)

References 30 publications

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“…One of the major differences between gallbladder and colorectal cancer surgery is that in the latter the tumors are known preoperatively and thereby handled using oncologic principles. This is in contrast to gallbladder cancer, which has been thought to be seldom known preoperatively 28. However, our study on open cholecystectomies showed that the indication for surgery was “suspicion of malignancy” in 40% of the cases and “jaundice” or “acute cholecystitis” in another 44%.…”

Section: Discussioncontrasting

confidence: 60%

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Lundberg

Kristoffersson

2001

J Hep Bil Pancr Surg

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Laparoscopic surgery has replaced conventional open cholecystectomy for benign gallbladder disease. A major concern is how to handle gallbladder cancer in the laparoscopic era, since there are numerous case reports of port site metastases from gallbladder cancer after laparoscopic cholecystectomy. There are also many experimental studies favoring the opinion that the laparoscopic technique implies a higher risk of spreading malignant disease. This opinion has gained wide acceptance despite little previous clinical effort to determine the risk of tumor dissemination and the lack of comparisons between open and laparoscopic surgery. This report is a short summary of our own studies and present knowledge with special respect to the clinical aspects of the development and incidence of abdominal wall metastases. Among 270 patients with verified gallbladder carcinoma in whom 210 had open surgery and 60 a laparoscopic cholecystectomy, 12 patients (6.5%) in the open cholecystectomy group and 9 (15%) in the laparoscopic group developed incisional metastases. Although the sparse clinical documentation does not unavoidably mean that laparoscopic cholecystectomy has an increased risk of disseminating tumor cells, we recommend open surgery in cases of known or suspected gallbladder carcinoma.

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Section: Discussioncontrasting

confidence: 60%

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Lundberg

Kristoffersson

2001

J Hep Bil Pancr Surg

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“…by carcinogenous gall [2]. The changedchemical milieu is accused of causing lithogenesis, chronic cholecystitis, and carcinogenesis (2, 56,57).…”

Section: Cholelithiasismentioning

confidence: 99%

“…The causal pathogenesis of the initial cell transformation is still unknown and probably manifold [2, 561. KOO et a1 [56] assume chemical carcinogens to be important etiological factors in gallbladder carcinoma, with gallstones playing a supporting role in the sense of a syncarcinogenesis. Therefore the formation of gallbladder carcinoma is undoubtedly based on the result of an inter-action between a local malignant process and the whole organism [65].…”

Section: Pathogenesismentioning

confidence: 99%

Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature

Sons¹,

Borchard²,

Joel³

1985

Journal of Surgical Oncology

127

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From 1950 to 1982, 287 patients with cancer of the gallbladder were autopsied. The ratio of men to women was 1:3.7. The average age of women was 70 years; that of men was 69.5 years. Most tumors (67.7%) had grown by diffuse infiltration and one-third (32.3%) were polypous-exophytic. Fundus and collum of the gallbladder showed an equal frequency (24%) of tumor localisation. The percentage of all gallbladder malignomas that were adenocarcinomas of various differentiation was 84.6, and 10.9% were anaplastic carcinomas, the rest consisted of squamous cell carcinomas (3.7%) and 0.8% sarcomas. Metastases were found in 265 cases (92.3%). Tumorous infiltration, lymph node metastases, and visceral metastases are discussed. A cholelithiasis was found in 78.4%. The results are compared with the literature.

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“…Metastases from gall bladder carcinoma commonly affect the local areas such as liver, duodenum and the para-aortic lymph nodes [3]. Although the atypical presentations and unusual associations of carcinoma gall bladder are known [4], but initial clinical presentation with distant metastasis is rare [1,5].…”

Section: Introductionmentioning

confidence: 99%

Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity

et al. 2009

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Distant metastases are rare form of presentation of carcinoma gall bladder. Bony pain as initial presentation is quite unusual. A 50-year-old woman presented with the pain in right shoulder. Investigation showed metastatic adenocarcinoma in the head of humerus and the primary was found in the gall bladder. She received local radiotherapy for bone metastases and undergoing systemic chemotherapy. Carcinoma gall bladder is a common abdominal malignancy, mostly presenting in advanced stage with abdominal symptoms and obstructive jaundice. In presence of metastasis, the management is palliative and role of chemotherapy is limited for palliation symptoms.

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Carcinoma of the gallbladder

Cited by 37 publications

References 30 publications

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Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature

Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity

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