Carcinoma of the esophagus developing at the site of lye stricture

Blgelow, Nolton H.

doi:10.1002/1097-0142(195311)6:6<1159::aid-cncr2820060606>3.0.co;2-b

Cited by 43 publications

(11 citation statements)

References 18 publications

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“…Their mean age is lower than that of those who had not suffered from lye corrosion (54.1 vs. 59.8 years). The latency period between the corrosive burn and the diagnosis of scar carcinoma is essentially longer than in the corresponding literature [4,8,19,24]: 46.1 years as opposed to 30-35 years. However, the mean age of our patients with scar carcinoma is higher than that in other reports [4,15].…”

Section: Discussionmentioning

confidence: 80%

“…Oesophageal carcinoma was found in 7 out of 200 patients with corrosive burn (3.5%) in the material of Bigger and Vinson [5], in 9 out of 381 (2.4%) in that of Kiviranta [15], and in 2 out of 50 corrosive cases in that of Kay [4]. Carcinoma developing on the basis of a previous corrosive stricture was demonstrated in 5.5% of the oesophageal cancer cases by Benedict [3], in 1.2% by Kiviranta [15], in 6% by Dubecz [8], in 0.8% by Lawler [17] and in 1.4% by Hopkins and Postlethwait [10].…”

Section: Discussionmentioning

confidence: 99%

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Late malignant transformation of chronic corrosive oesophageal strictures

Csíkos

Horváth

Petri

et al. 1985

Langenbecks Arch Chiv

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The number of patients with scar carcinoma of the oesophagus developing on the basis of a corrosive stricture seems to have been rising in the past two decades. 36 patients of this kind were treated surgically between 1965 and 1984; this is the second largest series in the literature. The patients with scar cancer comprised 7.2% of the overall oesophageal carcinoma cases; this ratio is currently the highest of all in the literature. The interval between the caustic burn and the diagnosis of scar carcinoma was found to be 46.1 years; this is higher than the 30-35 years generally accepted so far. It was 50.9 years in those patients who drank lye before the age of 12, but 14 years less when it happened in adulthood. The long-term survival time proved to be excellent: 45.6% of the resected cases were alive after 5 years and 14.4% after 10 years. The explanation of the good prognosis lies in the fact that carcinoma developing in a lye stricture is at first surrounded by a rigid scar which allows only its intraluminal growth, and it causes early dysphagia through luminal obstruction. Early dissemination is prevented for the same reason. One-stage resection and replacement is suggested in the radically operable cases. In patients with oesophageal corrosive stricture which needs operation, both a by-pass procedure and resection can be adopted, but it should be pointed out that malignancy may develop even years after the operation in the remaining part of the gullet. Total oesophagectomy is therefore suggested instead of bypass.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Late malignant transformation of chronic corrosive oesophageal strictures

Csíkos

Horváth

Petri

et al. 1985

Langenbecks Arch Chiv

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“…Stressing the hazards of dissecting out a severely damaged oesophagus, many surgeons advocate and perform bypass procedures with colon transplant (Nardi, 1957;Chien et al, 1974;Kirsch and Ritter, 1976). Nevertheless, the development of carcinoma in a residual stenosed oesophagus is well established (Benedict, 1941 ;Bigger and Vinson, 1950;Kiviranta, 1952;Bigelow, 1953;Arrants et al, 1965;Gerami et al, 1971;Imre and Kopp, 1972). In the present authors' department, bypass procedures for corrosive oesophageal stricture have been superseded since 1972 by oesophageal resection and reconstruction by cervical oesophagogastrostomy.…”

Section: K T I a N D V S I V A L O G A N A T H A N *mentioning

confidence: 93%

Oesophageal resection with cervical oesophagogastrostomy for corrosive oesophageal stricture

Sivaloganathan

1978

British Journal of Surgery

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An 8-year experience of the surgical treatment of 28 patients with corrosive oesophageal stricture is reviewed. Eight patients underwent oesophageal bypass using colonic or jejunal graft with one death (12.5 per cent mortality). The single death (5 per cent mortality) among 20 patients undergoing oesophageal resection was not related to the technical difficulty of the operation. In 17 of these patients reconstruction was by cervical oesophagogastrostomy and in 2 by pharyngogastrostomy. One case of oesophageal carcinoma occurred among 5 cases of corrosive stricture exceeding 20 years in duration. Oesophageal resection for severe corrosive stricture is not a hazardous procedure as generally believed and is desirable in view of the pre-malignant nature of corrosive stricture. Reconstruction by cervical oesophagogastrostomy after oesophageal resection is advantageous because of its relative simplicity and safety.

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“…Scar tissue is probably a premalignant condition (Alvarez and Colbert, 1963;Benedict, 1941;Bigelow, 1953;Dor et al, 1960a;Imre and Gergely, 1971;Sytnik and Petrov, 1968). The danger increases if there is chronic irritation at the site of the scar.…”

mentioning

confidence: 99%