Carcinoma of the esophagus

Hoffmann, Thomas H.; Kelley, Jerry R.; Graver, Frederick L.; Trinkle, J. Kent

doi:10.1016/s0022-5223(19)37658-5

Cited by 11 publications

(5 citation statements)

References 10 publications

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“…Satisfactory restoration of the swallowing mechanism was achieved in all the patients, but the survival rate was not improved essentially. This view is in agreement with that of other series [3,13].…”

Section: Discussionsupporting

confidence: 94%

“…The resectability rate is twice as high in patients with squamous cell carcinoma as the rate in patients with adenocarcinoma. This is in agreement with our findings of metastatic nodes in the two types; the disease was localized in 44% of the patients with squamous cell tumors and in 22% of those with adenocarcinoma [2,3,[5][6][7][8][9][10].…”

Section: Discussionsupporting

confidence: 92%

“…In all series, about two-thirds of the patients who undergo "curative" resection have metastases in the regional lymph nodes. Approximately half of the patients with carcinoma of the esophagogastric junction are already inoperable by the time they seek medical advice [3,4]. The greatest hope for improvement in the treatment of cancer of the esophagus and cardia lies in its early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…This alternative procedure gives satisfactory palliation in the majority of patients.Nearly 50% of all cancers affecting the esophagus occur at the esophagogastric junction, and these lesions have a poor prognosis. The average survival after the onset of symptoms in untreated patients is less than a year [1][2][3].The subject of the present article is a clinical analysis of patients with malignant lesions in the lower esophagus and esophagogastric junction treated in two thoracic departments in Denmark.…”

mentioning

confidence: 99%

“…Nearly 50% of all cancers affecting the esophagus occur at the esophagogastric junction, and these lesions have a poor prognosis. The average survival after the onset of symptoms in untreated patients is less than a year [1][2][3].…”

mentioning

confidence: 99%

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Surgical treatment for malignant lesions of the distal part of the esophagus and the esophagogastric junction

1985

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The treatment of 364 patients with carcinoma of the distal part of the esophagus and the esophagogastric junction is reported. Eighty‐two percent of the patients were subjected to operation and the resect ability rate was 52%. At operation 230 patients had lymph node metastases and 115 patients had distant metastases to abdominal organs. The resection rate was significantly higher in patients with squamous cell carcinoma than in patients with adenocarcinoma, and about two‐thirds of the resections were considered as “curative” treatment. The operative mortality rate for the entire period was high (24%), but the mortality decreased in the last 10‐year period. The 5‐year survival rate after resection was in the same level as in other series; the survival rate for patients with squamous cell carcinoma was considerably higher than for patients with adenocarcinoma. If surgical resection is not feasible, surgical bypass of the obstructing lesion is indicated. This alternative procedure gives satisfactory palliation in the majority of patients.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Surgical treatment for malignant lesions of the distal part of the esophagus and the esophagogastric junction

1985

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Preoperative in vitro chemosensitivity test of esophageal cancer with endoscopic specimens

Kondo

Okuma

Yoshioka

et al. 1993

Cancer

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Background. From January 1990 to June 1991, the authors tested in vitro chemosensitivity before surgery with endoscopic biopsy specimens from 23 patients with intrathoracic esophageal cancer. Methods. The authors tested eight anticancer agents using the dye exclusion method, and all 23 patients received chemotherapy with the most sensitive three drugs according to the results of the chemosensitivity test. Results. Ten patients (43.5%) had a tumor reduction of more than 50% on radiologic studies, and 4 patients (17.4%) had a good histologic effect. Conclusions. The chemosensitivity test is useful in selecting preoperative chemotherapeutic agents for patients with esophageal cancer.

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