Carcinoma of the Colon Complicating Chronic Ulcerative Colitis

Weckesser, Elden C.

doi:10.1001/jama.1953.03690100023008

Cited by 36 publications

(8 citation statements)

References 7 publications

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“…Three were less than 30 years old, nine were in the fourth decade, and five were in the fifth decade. This supports the widely held view (Weckesser and Chinn, 1953;Bargen and Gage, 1960) that cancer following ulcerative colitis occurs at a younger age than does cancer of the large bowel not preceded by ulcerative colitis.…”

supporting

confidence: 86%

Ulcerative colitis in the United States Army in 1944: Follow-up with particular reference to mortality in cases and controls

Nefzger¹,

Acheson²

1963

Gut

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EDITORIAL SYNOPSIS This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulcerative colitis (2-9 %) and cancer of the caecum, colon, and rectum (3-2 %). The mortality from ulcerative colitis occurred mainly in the first and immediately subsequent years after diagnosis while most of the deaths from cancer occurred in later years. A striking correlation is shown between bad prognosis and the extent of radiological involvement of the colon in 1944. MATERIALS AND METHODSSAMPLING Five hundred and twenty-five individuals were selected from among the admissions to Army hospitals2 for ulcerative colitis during 1944. Those selected were the males with at least 90 days of Army service who had not already been admitted to an Army hospital at which a diagnosis of ulcerative colitis was made. The symptoms at the onset of the illness and at the reference point, i.e., the date of admission to hospital, and clinical procedures carried out during the period in hospital have been described elsewhere (Acheson and Nefzger, 1963).Controls were selected from a 0 1 % sample of all males discharged from the Army to civil life during the interval between 1944 and 30 June 1947. They were matched individually to ulcerative colitis cases on the basis of age, race, and rank and were required to have been on active duty with the Army on the day when the matched case was admitted to hospital (Acheson and Nefzger, 1963).

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supporting

confidence: 86%

Ulcerative colitis in the United States Army in 1944: Follow-up with particular reference to mortality in cases and controls

Nefzger¹,

Acheson²

1963

Gut

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“…Among these patients the chance of developing carcinoma was about 30 times that of the general population. Several other recent studies confirm the unduly high risk of carcinoma in ulcerative colitis, particularly when the disease has lasted for 10 years or more (Kiefer et al, 1951-Counsell andDukes, 1952;Weckesser and Chinn, 1953;Dukes, 1954).…”

Section: Re'ationship Of Abnormal Cells To Carcinoma Of Colonmentioning

confidence: 84%

Abnormal Epithelial Cells in Ulcerative Colitis

Boddington¹,

Truelove²

1956

BMJ

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“…The exact incidence of malignant change varies, usually ranging from 1o% to 14% (Edwards and Truelove, 1964), whereas in the population at large the incidence is 0.06 % (Weckesser and Chinn, 1953). It is also accepted that the likelihood of developing a carcinoma increases with the duration of the colitis (Lagercrantz, 1955;Rosenqvist, Lagercrantz, Ohrling, and Edling, 1959;Slaney and Brooke, 1959), reaching definite clinical significance after 10 years (Hinton, 1966) and rising to an incidence of 56% after 30 years (de Dombal, Watts, Watkinson, and Goligher, 1966).…”

Section: Discussionmentioning

confidence: 99%

Radiological findings in carcinoma of the colon complicating chronic ulcerative colitis.

Fennessy¹,

Sparberg²,

Kirsner³

1968

Gut

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Carcinoma of the Colon Complicating Chronic Ulcerative Colitis

Abstract: Owing to lack of space, some of the bibliographic references have been omitted from The Journal and will be included only in the authors' reprints.

Cited by 36 publications

References 7 publications

Ulcerative colitis in the United States Army in 1944: Follow-up with particular reference to mortality in cases and controls

Ulcerative colitis in the United States Army in 1944: Follow-up with particular reference to mortality in cases and controls

Abnormal Epithelial Cells in Ulcerative Colitis

Radiological findings in carcinoma of the colon complicating chronic ulcerative colitis.

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