Carcinoma of the cervix: analysis of complications after primary external beam radiation and Ir-192 HDR brachytherapy

Kapp, Karin S.; Stuecklschweiger, Georg; Kapp, Daniel S.; Poschauko, J.; Pickel, H.; Hackl, A.

doi:10.1016/s0167-8140(96)01881-6

Cited by 79 publications

(37 citation statements)

References 49 publications

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“…Similarly, the incidence of radiation cystitis was increased in the patients with late stage (IIIb) tumor progression as compared with patients with early stage (Ib, IIa) tumor progression (P < 0.05). These results were in accordance with previous studies (Kapp et al, 1997). It is possible that limited, moderate or severe radiation proctitis and radiation cystitis in patients with early tumor stage with favorable anatomy permitted optimal site-directed radiation, thus sparing normal tissue.…”

Section: Discussionsupporting

confidence: 92%

“…Combinational therapy of HDRICB and EBRT has been widely used for the treatment of cervical carcinoma (Kapp et al, 1997;Mabuchi et al, 2010;Niibe et al, 2010). However, complications, including radiation proctitis and radiation cystitis, commonly occur following irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…Using an in-house scoring system and the FrenchItalian Glossary (FIG), Kapp and colleagues rated the complications in patients with Stage IB-IVB cervical carcinoma (Kapp et al, 1997). They found that several pretreatment factors influenced the likelihood of complications, including age, marked obesity (Hanks et al, 1983;Combes et al, 1985), previous surgery, history of inflammatory disease (Hanks et al, 1983) and stage (Lanciano et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…High-dose-rate intracavitary brachy therapy (HDRICB) combined with external beam radiotherapy (EBRT) showed various advantages for the management of cervical carcinoma, including elimination of personnel exposure and short treatment time with the possibility of maintaining exact applicator geometry. Therefore, this therapy combination is widely applied in Japan and parts of Europe (Kapp et al, 1997;Mabuchi et al, 2010;Niibe et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Possible Risk Factors Associated with Radiation Proctitis or Radiation Cystitis in Patients with Cervical Carcinoma after Radiotherapy

Yang

Liu²

2012

Asian Pacific Journal of Cancer Prevention

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Radiation proctitis and radiation cystitis are major complications for patients with cervical carcinoma following radiotherapy. In the present study, we aimed to determine the potential risk factors for the development of radiation proctitis and radiation cystitis after irradiation. A total of 1,518 patients with cervical carcinoma received external beam radiotherapy (EBRT) followed by high-dose-rate intracavitary brachytherapy (HDRICB) in our hospital. The incidences of radiation proctitis and radiation cystitis were recorded and associations with different factors (age, time period, tumor stage) were analyzed with c 2 (chi-squared) and Fisher exact tests. We found that 161 and 94 patients with cervical carcinoma were diagnosed with radiation proctitis and radiation cystitis, respectively, following radiotherapy. The prevalence of Grade I-II radiation proctitis or radiation cystitis was significantly lower than that of Grade III (radiation proctitis: 3.82% vs. 6.76%, P < 0.05; radiation cystitis: 2.31% vs. 3.87%, P < 0.05) and was significantly enhanced in patients with late stage (IIIb) tumor progression compared to those in early stage (Ib, IIa) (P < 0.05). Moreover, the incidence of radiation proctitis and cystitis was not correlated with age or, time period following radiation, for each patient (P > 0.05). These observations indicate that a late stage of tumor progression is a potential risk factor for the incidence of radiation proctitis and cystitis in cervical carcinoma patients receiving radiotherapy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Possible Risk Factors Associated with Radiation Proctitis or Radiation Cystitis in Patients with Cervical Carcinoma after Radiotherapy

Yang

Liu²

2012

Asian Pacific Journal of Cancer Prevention

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“…Several investigators [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] previously demonstrated that various clinical and treatment-related parameters, including age, diabetes mellitus, disease stage, EBRT dose, fractionation of brachytherapy, Point A dose, and rectal dose, were correlated with late rectal complications (LRC). In particular, RT dose and volume are considered the most important parameters associated with LRC.…”

mentioning

confidence: 99%

Dosimetric parameters that predict late rectal complications after curative radiotherapy in patients with uterine cervical carcinoma

Kim

Choi

Park

et al. 2005

Cancer

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Expertise‐seeking research studies how people search for expertise and choose whom to contact in the context of a specific task. An important outcome are models that identify factors that influence expert finding. Expertise retrieval addresses the same problem, expert finding, but from a system‐centered perspective. The main focus has been on developing content‐based algorithms similar to document search. These algorithms identify matching experts primarily on the basis of the textual content of documents with which experts are associated. Other factors, such as the ones identified by expertise‐seeking models, are rarely taken into account. In this article, we extend content‐based expert‐finding approaches with contextual factors that have been found to influence human expert finding. We focus on a task of science communicators in a knowledge‐intensive environment, the task of finding similar experts, given an example expert. Our approach combines expertise‐seeking and retrieval research. First, we conduct a user study to identify contextual factors that may play a role in the studied task and environment. Then, we design expert retrieval models to capture these factors. We combine these with content‐based retrieval models and evaluate them in a retrieval experiment. Our main finding is that while content‐based features are the most important, human participants also take contextual factors into account, such as media experience and organizational structure. We develop two principled ways of modeling the identified factors and integrate them with content‐based retrieval models. Our experiments show that models combining content‐based and contextual factors can significantly outperform existing content‐based models.

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High‐dose‐rate versus low‐dose‐rate intracavitary therapy for carcinoma of the uterine cervix

Hareyama

Sakata

Oouchi

et al. 2001

Cancer

125

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BACKGROUND This was a prospective randomized clinical trial undertaken at our institution to compare low‐dose‐rate (LDR) intracavitary radiation therapy versus high‐dose‐rate (HDR) intracavitary radiation therapy for the treatment of cervical carcinoma. METHODS From January 1984 to December 1997, a total of 132 patients with Stage II or IIIB of invasive carcinoma of the uterine cervix were entered into this randomized study. Treatment arm by HDR or LDR was allocated according to the month of each patient's birth. External irradiation consisted of whole pelvis irradiation and pelvic irradiation. Doses of external irradiation for both groups were identical. The authors used 0.588 as the conversion factor of total intracavitary dose from LDR to HDR. RESULTS The 5‐year disease specific survival rates of Stage II and III patients treated with HDR were 69% and 51% whereas those with LDR were 87% and 60%, respectively. The 5‐year pelvic recurrence free survival rates of Stage II and III patients treated with HDR were 89% and 73% whereas those with LDR were 100% and 70%, respectively. There was no significant difference in disease specific survival or pelvic recurrence free survival rates between HDR and LDR. The actuarial complication rate (Radiation Therapy Oncology Group Grade 3, 4, or 5) at 5 years was 10% in the HDR group and 13% in the LDR group, and the difference between the HDR and LDR groups was not statistically significant. CONCLUSIONS The pelvic control or actuarial complication rates were comparable between HDR and LDR treatment. The difference between the disease specific survival rates for HDR and LDR was not statistically significant for Stage II or III, although in Stage II, patients treated with LDR appeared to have a better survival rate than those treated with HDR. Cancer 2002;94:117–24. © 2002 American Cancer Society.

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Carcinoma of the cervix: analysis of complications after primary external beam radiation and Ir-192 HDR brachytherapy

Cited by 79 publications

References 49 publications

Possible Risk Factors Associated with Radiation Proctitis or Radiation Cystitis in Patients with Cervical Carcinoma after Radiotherapy

Possible Risk Factors Associated with Radiation Proctitis or Radiation Cystitis in Patients with Cervical Carcinoma after Radiotherapy

Dosimetric parameters that predict late rectal complications after curative radiotherapy in patients with uterine cervical carcinoma

High‐dose‐rate versus low‐dose‐rate intracavitary therapy for carcinoma of the uterine cervix

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