Carcinoma of the body of the uterus in childhood

Gilbert, Judson B.

doi:10.1016/s0002-9378(32)90721-2

Cited by 6 publications

(2 citation statements)

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“…It is difficult to provide precise estimations of the incidence of EC in the adolescent population because its occurrence in very young patients is exceedingly rare. However, the youngest patients reported in the literature were an 11-year-old [ 6 ] and a 13-year-old [ 7 ] girl.…”

Section: Introductionmentioning

confidence: 99%

“…All retrieved articles were in English. During the search it became apparent that scientific information regarding the occurrence of EC in AYAs, and specifically in adolescent patients, is not new as it was recognized in many early reports [ 6 , 34 , 35 , 36 , 37 ]. Later contributions described a 19-year-old woman with EC in endometrial polyp who later gave birth to a child who was 2 years old at her follow-up [ 38 ], or considered patients in an age range from 21 to 39 years [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Fertility-Sparing Methods in Adolescents Affected by Endometrial Cancer: A Comprehensive Review

Gałczyński

Olcha

Romanek-Piva

et al. 2021

JCM

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Although in developed countries endometrial cancer (EC) is the most common gynecological malignancy, its occurrence in adolescents is exceedingly rare. The increasing rate of obesity in children and adolescents is held responsible for the increasing prevalence of EC in younger cohorts of patients. The diagnosis of this malignancy can have devastating consequences for future fertility because standard treatment protocols for EC include hysterectomy. Here, we present the first detailed review of the world literature on EC in subjects aged 21 years or younger (n = 19). The mean age at diagnosis was 16.7 ± 0.6 years. One patient (5.3%) had a Type II (high-risk) disease. No communication retrieved from the search reported on patient death; however, two (10.5%) patients were lost to follow-up. There was also a high proportion (five subjects, or 26.3%) of cases with genetic background (Cowden syndrome and Turner syndrome), therefore genetic screening or a direct genetic study should be considered in very young patients with EC. The current fertility-sparing options, limited to Type I (low-risk) disease, are presented and discussed. Such information, obtained from studies on older women, translates well to adolescent girls and very young women. Careful anatomopathological monitoring at follow-up is essential for the safety of a conservative approach. Improved survival in very young EC patients makes the preservation of fertility a central survivorship issue, therefore both patients and caregivers should undergo counseling regarding available options. Moreover, our study suggests that genetic syndromes other than Lynch syndrome may be associated with EC more frequently than previously thought.

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Section: Introductionmentioning

confidence: 99%