Carcinoma of the Bladder and Multiple Unrelated Malignancy1

Dual Pathology- Clear Cell Variant of Renal Cell Carcinoma and High Grade Papillary Urothelial Carcinoma of Urinary Bladder a Rare Entity: Case Report

“…It is a well known fact that urinary tract is one of the most common sites for multiple primary tumors. Extensive search revealed that multiple primary tumors occur in 3.1% of total cancer patients and 13.9% of these have genitourinary tumors 4 .Multiple malignant tumors involving more than one genitourinary site are rare.In one study, 5.4% of the patients with urinary bladder neoplasms had malignant tumors outside the urothelium and of these 4.3% were renal cell carcinomas 5 . Several studies done by Begget al 6 , Neuzillet et al 7 , Jensen et al 8 and others 9,10,11 concluded that urinary bladder cancer patients have higher risk of development of renal cell carcinoma.Neuzilletet al 7 and Rabbaniet al 9 concluded that this dual association is usually observed in papillary subtypes of renal cell carcinoma.But in our study, this dual association was observed between the clear cell variant of renal cell carcinoma and high grade papillary urothelial carcinoma of urinary bladder.…”

Concurrent diagnosis of urothelial carcinoma and squamous cell carcinoma of the bladder in a patient with a vesicorectal fistula from invasive rectal cancer

“…Ward-McQuaid found a total of 340 malignant non-urothelial tumors (5.4%) among 6263 patients with bladder tumors. 2 Of these, 12.3% were of colorectal origin. Nonetheless, concomitant transitional cell carcinoma of the bladder occurring synchronously with a locally advanced colorectal malignancy causing a vesicoenteric fistula is extremely rare.…”

“…The existence of multiple primary malignant neoplasms occurs more frequently than just a result of a random chance. Ward‐McQuaid found a total of 340 malignant non‐urothelial tumors (5.4%) among 6263 patients with bladder tumors 2 . Of these, 12.3% were of colorectal origin.…”

Simultaneous Occurrence of Urothelial Bladder Carcinoma and Primary Retroperitoneal Leiomyosarcoma

“…Summarizing all data from several large surveys up to 1983, association of the urological organs with at least one second primary tumor was 13.5% [2], Recently, in a series of 10,014 patients with bladder cancer, the incidence of subsequent primary cancer was reported to be 6.5% [8], One-third of these second primary neoplasms occurs at the same time as the bladder tumor, while two-thirds are metachronous [7], The latter are frequently localized in the prostate, skin and lip, colorectal area, bronchial system, breast, uterus and stomach [2,7,8], However, to our knowledge the simultaneous occurrence of a primary urothelial bladder cancer and a primary retroperitoneal leiomyosarcoma has not yet been described.…”