Carcinoma of the Bifurcation of the Hepatic Ducts

Tsuzuki, Toshiharu

doi:10.1001/archsurg.1983.01390100021006

Cited by 93 publications

(69 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The similar survival and significantly different stage distribution in patients with and without major hepatectomies support the use of major hepatectomies for patients with advanced disease. We consider that caudate lobectomy is also an essential component of radical surgery for hilar cholangiocarcinoma, as mentioned in previous reports, 13,15,18,19,26,31 and we believe that this contributed to the good long-term results in our patients treated with resectional surgery. However, we could not assess the effects of caudate lobectomy because it was incorporated in 92.6% of major hepatic resections.…”

Section: Discussionsupporting

confidence: 69%

Improved Surgical Results for Hilar Cholangiocarcinoma With Procedures Including Major Hepatic Resection

Kosuge¹,

Yamamoto²,

Shimada³

et al. 1999

Annals of Surgery

317

236

View full text Add to dashboard Cite

ObjectiveTo evaluate the long-term outcome of aggressive surgery incorporating hepatic resection and systematic nodal dissection for advanced carcinoma involving the hepatic hilus. Summary Background DataFew long-term results are available regarding radical surgery incorporating major hepatectomy and nodal dissection. MethodsA retrospective analysis was undertaken in 107 patients with carcinoma involving the hepatic hilus treated between 1980 and 1997. Resectional surgery was performed in 65 patients, 52 of whom underwent major hepatectomies. The effects of clinical and pathologic factors were assessed by univariate and multivariate analyses. ResultsSixty percent of the patients with resectional surgery had stage IVA or IVB disease, and 92.3% of them underwent major hepatectomies. No in-hospital deaths were encountered in the 35 most recent resections, whereas there were six deaths in the early period. Resectional surgery was associated with a survival benefit, especially when resection margins were free from cancerous infiltration. The estimated 5-year survival rate after resection, including all deaths, was 34.8%; this was 51.6% when the margins were clear. Nodal involvement was documented in 44.6% of the resections. However, patients with metastases limited to the regional nodes showed a survival rate similar to that in patients without nodal involvement. Significant predictive factors for survival after resection were extension to the gallbladder, nodal status, resectional margins, histologic type, and gender.

show abstract

Section: Discussionsupporting

confidence: 69%

Improved Surgical Results for Hilar Cholangiocarcinoma With Procedures Including Major Hepatic Resection

Kosuge¹,

Yamamoto²,

Shimada³

et al. 1999

Annals of Surgery

317

236

View full text Add to dashboard Cite

show abstract

“…Blumgart et al [27] first described concomitant caudate lobectomy in 1979, but did not clearly state the rationale for it. Later, Japanese researchers, Tsuzuki et al [24], Mizumoto et al [28], Iwasaki et al [29], and Nimura et al [30] successively published clinical study reports, and studies have demonstrated in more detail the clinically oriented local anatomy of the hepatic caudate lobe and the surgical anatomy of intrahepatic bile duct branches and the hepatic hilum [31][32][33][34][35][36][37], achieving a worldwide consensus about the rationality of caudate lobectomy in surgery for hilar cholangiocarcinoma [38,39]. In our department, we have performed concomitant caudate lobectomy in only 15 (40.5%) of the 37 patients to date.…”

Section: History Of Surgical Treatment Of Hilar Cholangiocarcinomamentioning

confidence: 99%

“…In 1976, Fortner et al [23] succeeded in left hepatic lobectomy followed by heterotopic liver transplantation, and the patient survived for 8 months. From 1980 onwards, many reports were published from Japan as well as from Europe and the United States, and the number of cases of combined portal vein and liver resection increased yearly, as reported by Tsuzuki et al [24], Sakaguchi et al [25], and Nimura et al [26]. Caudate lobectomy is another important surgical factor in performing radical surgery for hilar cholangiocarcinoma.…”

Section: History Of Surgical Treatment Of Hilar Cholangiocarcinomamentioning

confidence: 99%

Clinicopathological Study of Patients Undergoing Resection of Hilar Cholangiocarcinoma

Hidaka

2007

Kurume Med. J.

View full text Add to dashboard Cite

“…The necessity of resecting the caudate lobe has been described by Japanese authors [12,13,[42][43][44] . Nimura et al [43] firstly described caudate lobectomy for hilar bile duct cancer.…”

Section: Need For Hepatectomy and Caudate Lobectomymentioning

confidence: 99%

“…Radical resection is still the only a chance for cure, and various types of surgical procedure have been applied [1][2][3]6,[12][13][14] . Extended hemihepatectomy has recently been recognized as the standard curative treatment for hilar bile duct cancer and has acceptable mortality [15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Current surgical treatment for bile duct cancer

Seyama

Makuuchi²

2007

WJG

106

View full text Add to dashboard Cite

Since extrahepatic bile duct cancer is difficult to diagnose and to cure, a safe and radical surgical strategy is needed. In this review, the modes of infiltration and spread of extrahepatic bile duct cancer and surgical strategy are discussed. Extended hemihepatectomy, with or without pancreatoduodenectomy (PD), plus extrahepatic bile duct resection and regional lymphadenectomy has recently been recognized as the standard curative treatment for hilar bile duct cancer. On the other hand, PD is the choice of treatment for middle and distal bile duct cancer. Major hepatectomy concomitant with PD (hepatopancreatoduodenectomy) has been applied to selected patients with widespread tumors. Preoperative biliary drainage (BD) followed by portal vein embolization (PVE) enables major hepatectomy in patients with hilar bile duct cancer without mortality. BD should be performed considering the surgical procedure, especially, in patients with separated intrahepatic bile ducts caused by hilar bile duct cancer. Right or left trisectoriectomy are indicated according to the tumor spread and biliary anatomy. As a result, extended radical resection offers a chance for cure of hilar bile duct cancer with improved resectability, curability, and a 5-year survival rate of 40%. A 5-year survival rate has ranged from 24% to 39% after PD for middle and distal bile duct cancer.

show abstract

Carcinoma of the Bifurcation of the Hepatic Ducts

Cited by 93 publications

References 5 publications

Improved Surgical Results for Hilar Cholangiocarcinoma With Procedures Including Major Hepatic Resection

Improved Surgical Results for Hilar Cholangiocarcinoma With Procedures Including Major Hepatic Resection

Clinicopathological Study of Patients Undergoing Resection of Hilar Cholangiocarcinoma

Current surgical treatment for bile duct cancer

Contact Info

Product

Resources

About