Carcinoma of Stomach in Relation to Abo Blood-Groups

Jennings, Denys; Balme, R.H.; Richardson, Jim

doi:10.1016/s0140-6736(56)91386-1

Cited by 19 publications

(9 citation statements)

References 3 publications

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“…Jennings, Balme, and Richardson (1956), who studied 129 patients at another hospital in London, and Billington (1956), who studied 483 patients in Sydney, found a higher frequency of group A compared with the other groups in patients with cancers in the cardia and antrum while group 0 predominated in patients with cancers in the body of the stomach. In contrast, Haddock and McConnell (1956) found an excess of group A in the cardia and midzone cases combined and an excess of group 0 in the antral cases.…”

Section: Resultsmentioning

confidence: 97%

Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient

Glober¹,

Cantrell²,

Doll³

et al. 1971

Gut

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SUMMARY ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals.The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group 0 subjects, in close agreement with many previous reports throughout the world. More detailed analysis failed to support the suggestion that there was any special correlation between either ABO or Rhesus blood groups and the site of origin of the tumour within the stomach or the sex or age of the patient.Male predominance among the patients was noted to be greater at ages 40-69 years than at other ages and greater for tumours of the upper two thirds of the stomach than for tumours that arose distally.The relevance of genetic factors to the aetiology of gastric carcinoma is widely accepted and is derived from familial and blood group studies (McConnell, 1966). The precise contribution of these genetic factors, however, is unknown. Aird, Bentall, and Roberts (1953) were the first to study ABO blood groups in a large number of patients with gastric cancer and found an excess of group A and a deficiency of group 0 in comparison with control patients. Subsequently, at least 71 controlled series have been published; in 55 of these the cancer patients showed an excess of group A, in 14 a slight predominance of group A, and in only two a deficiency of group A (McConnell, 1966). These world-wide studies show that group A increases the risk of gastric malignancy by about 20 %, and that this proportional increase is approximately the same irrespective of whether the overall incidence is low, intermediate, or high.To define more exactly the contribution of this genetic effect to the pathogenesis of gastric cancer, workers have examined blood groups in relation to such variables as tumour site, histology, gastric acidity, and age and sex of the patient. Among these studies was that of Doll, Swynnerton, and Newell (1960) who found a decreasing ratio of group A to

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Section: Resultsmentioning

confidence: 97%

Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient

Glober¹,

Cantrell²,

Doll³

et al. 1971

Gut

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“…Several authors, Billington (1956), Jennings, Palme andRichardson (1956) and Turunen and Pasila (1957) have classified their materials according to the supposed site of origin of the tum our growth. It is not possible to subdivide our m aterial obtained during the above mentioned period from serveral different hospitals.…”

Section: Present Investigationmentioning

confidence: 99%

Abo Blood Groups and Gastric Carcinoma

Beckman¹,

Ae²

1961

Hum Hered

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“…From his results, Jordal (1956), in Denmark, claimed a significant excess of A (his probability value was 6%), and Weiser (1957), in Germany, found a slight excess of A. Mayr, Diamond, Levine, andMayr (1956), in America, andJennings, Balme, andRichardson (1956), and Walther, Raeburn, and Case (1956), in England, showed an excess of A.…”

mentioning

confidence: 97%

“…K0ster et al (1955), Heist0 (1956), and Buckwalter et al (1956b agreed, but Clarke (1955), Clarke, Cowan, Wyn Edwards, Howel-Evans, McConnell, Woodrow, and Sheppard (1955), Billington (1956a), and Brown, Melrose, and Wallace (1956) found no significant difference between controls and patients with gastric ulcer. Jennings et al (1956) classified 119 cases of carcinoma of the stomach into three sites: (1) pyloric and antral, (2) cardiac, and (3) body, and found that the overall excess of group A in carcinoma of the stomach was due to the excess of that group in pyloric lesions. They found no association between blood groups and lesions elsewhere in the stomach.…”

mentioning

confidence: 99%

Blood Groups of Gastric Ulcer and Carcinoma

Beasley¹

1960

BMJ

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The earliest attempt to find a relationship between the ABO blood groups and disease was that of Alexander (1921). From a study of 50 malignant neoplasms he concluded that groups B and AB were peculiarly susceptible to various forms of neoplasm and that 0 was more stable or resistant, but admitted that his figures were too small for the susceptibility of group A to be discerned. He found that neoplasms in B and AB groups were severe and rapidly growing, while those in groups 0 and A were of low malignancy and of long duration.In the same year Buchanan and Higley (1921)

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Carcinoma of Stomach in Relation to Abo Blood-Groups

Cited by 19 publications

References 3 publications

Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient

Interaction between ABO and Rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient

Abo Blood Groups and Gastric Carcinoma

Blood Groups of Gastric Ulcer and Carcinoma

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