Carcinoma of nasopharynx in twins

Nevo, S.; Meyer, Willy; Altman, M

doi:10.1002/1097-0142(197109)28:3<807::aid-cncr2820280342>3.0.co;2-c

Cited by 32 publications

(8 citation statements)

References 4 publications

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“…Etiologic factors, including genetic and environmental agents, have been hypothesized but are still unproved (3)(4)(5). A very impressive family history is hereby exhibited.…”

Section: Advanced Nasopharyngeal Carcinoma Dizygotic Twins-a Rare Casmentioning

confidence: 86%

Advanced Nasopharyngeal Carcinoma and Radiation-Induced Meningioma in Dizygotic Twins—A Rare Case Report

Drumea

Bernstein

et al. 1996

Acta Oncologica

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“…Etiologic factors, including genetic and environmental agents, have been hypothesized but are still unproved (3)(4)(5). A very impressive family history is hereby exhibited.…”

Section: Advanced Nasopharyngeal Carcinoma Dizygotic Twins-a Rare Casmentioning

confidence: 86%

Advanced Nasopharyngeal Carcinoma and Radiation-Induced Meningioma in Dizygotic Twins—A Rare Case Report

Drumea

Bernstein

et al. 1996

Acta Oncologica

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“…Multiple cases of NPC occumng in fiit-degree relatives have long been documented in diverse populations with distinct risks of NPC (Stinson, 1940;Nevo, 1971;Ho, 1972;Brown et al, 1976;Lanier et al, 1979). We first confirmed this risk factor in Cantonese in our case-control study in Hong Kong in which 18 cases but only 4 controls had a first-degree relative with NPC (Yu et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Occupational and other non‐dietary risk factors for nasopharyngeal carcinoma in Guangzhou, China

Garabrant

Huang

et al. 1990

Intl Journal of Cancer

141

110

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We conducted interviews on 306 histologically confirmed incident cases of nasopharyngeal carcinoma (NPC) occurring in residents of Guangzhou City, China, who were under the age of 50, and an equal number of age-, sex-, and neighborhood-matched controls. We also interviewed 110 mothers of patients under 45 and 139 mothers of controls who were matched to patients under age 45, to obtain information on childhood exposures of study subjects. Occupational exposure to products of combustion (RR = 2.4, p = 0.001) and cotton dust (RR = 0.3, P = 0.01) was independently related to risk of NPC. Use of tobacco products showed a moderate association with NPC; a lifetime exposure of 30+ pack-year equivalents conferred a 2-fold increased risk. A history of chronic ear or nose condition (rhinitis, sinusitis, nasal polyp, otitis media) was another risk factor for NPC (RR = 2.2, p less than 0.0005), and 18 cases compared to 3 controls had a first-degree relative with NPC (RR = 6.0, p = 0.001).

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“…Familial aggregation of NPC has been widely documented in high-incidence (190,(250)(251)(252)(253), intermediate-incidence (254-257), and low-incidence populations (258)(259)(260)(261)(262)(263)(264)(265)(266)(267). Such clustering can result from shared genetic susceptibility, shared environmental risk factors, or both.…”

Section: Risk Factorsmentioning

confidence: 99%

The Enigmatic Epidemiology of Nasopharyngeal Carcinoma

Chang

Adami

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

1,145

1,009

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Nasopharyngeal carcinoma (NPC) has a unique and complex etiology that is not completely understood. Although NPC is rare in most populations, it is a leading form of cancer in a few well-defined populations, including natives of southern China, Southeast Asia, the Arctic, and the Middle East/North Africa. The distinctive racial/ethnic and geographic distribution of NPC worldwide suggests that both environmental factors and genetic traits contribute to its development. This review aims to summarize the current knowledge regarding the epidemiology of NPC and to propose new avenues of research that could help illuminate the causes and ultimately the prevention of this remarkable disease. Well-established risk factors for NPC include elevated antibody titers against the Epstein-Barr virus, consumption of salt-preserved fish, a family history of NPC, and certain human leukocyte antigen class I genotypes. Consumption of other preserved foods, tobacco smoking, and a history of chronic respiratory tract conditions may be associated with elevated NPC risk, whereas consumption of fresh fruits and vegetables and other human leukocyte antigen genotypes may be associated with decreased risk. Evidence for a causal role of various inhalants, herbal medicines, and occupational exposures is inconsistent. Other than dietary modification, no concrete preventive measures for NPC exist. Given the unresolved gaps in understanding of NPC, there is a clear need for large-scale, populationbased molecular epidemiologic studies to elucidate how environmental, viral, and genetic factors interact in both the development and the prevention of this disease. PurposeIntriguing hallmarks of nasopharyngeal carcinoma (NPC) include its striking racial/ethnic and geographic variation, as well as its multifactorial etiology involving the interplay of environmental, viral, and genetic risk factors. The precise roles of these factors in the development of NPC, however, remain unknown. The purpose of this review is to highlight what is understood about the epidemiology of NPC, as well as to present unresolved research questions that call for large-scale molecular epidemiologic studies of NPC to illuminate the underlying causes of this fascinating disease. Review MethodsA thorough review of the literature related to the etiology of NPC was undertaken, starting with a Medline search from 1966 onward. Additional papers, book sections, and monographs were identified through examination of reference lists. Because this review aims to present the epidemiologic evidence in a range of topic areas, rather than to calculate overall estimates of effect, formal quantitative methods were not used. All relevant papers have been cited to provide a comprehensive summary of the evidence. Inclusion or exclusion criteria were not applied to individual reports, but the strength, consistency, and relevance of the findings were considered in weighing the evidence.Descriptive Epidemiology

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Carcinoma of nasopharynx in twins

Cited by 32 publications

References 4 publications

Advanced Nasopharyngeal Carcinoma and Radiation-Induced Meningioma in Dizygotic Twins—A Rare Case Report

Advanced Nasopharyngeal Carcinoma and Radiation-Induced Meningioma in Dizygotic Twins—A Rare Case Report

Occupational and other non‐dietary risk factors for nasopharyngeal carcinoma in Guangzhou, China

The Enigmatic Epidemiology of Nasopharyngeal Carcinoma

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