“…A variety of reports has appeared in the literature which described entities that presented with clinical and radiographic features of inflammatory periodontal disease, but which did not respond adequately to conventional periodontal therapy, or were inconsistent with the general periodontal status of the patient. Histiocytosis X has presented with the clinical features of localized juvenile Periodontitis, as well as with features of both generalized and localized Periodontitis.13*14 Varying degrees of osseous destruction have also been reported to occur with malignant lymphoma of the oral cavity.15 Larheim et al 16 presented 31 cases involving carcinoma of the maxillary sinus, palate, and/or gingiva, and found that each of these was frequently associated with osseous destruction. A review of metastatic carcinomas which have appeared at mandibular sites has been reported by Hashimoto et al,17 and a case of metastatic hepatocellular gingival carcinoma with localized osseous destruction was presented by Morishita and Fukuda.18 Significantly, many of the foregoing cases occurred in patients with at least moderate periodontal disease.…”