Carcinoma of endocrine organs: Results of the RARECARE project

Zwan, Jan Maarten van der; Mallone, Sandra; Dijk, Boukje van; Bielska–Lasota, Magdalena; Otter, Renée; Foschi, Roberto; Baudin, Éric; Links, Thera P.

doi:10.1016/j.ejca.2012.01.029

Cited by 44 publications

(31 citation statements)

References 26 publications

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“…adolescents and young adults, disease-specific symptoms, health-related quality of life, survivorship, thyroid cancer 1 | I NT ROD UCTI ON Thyroid cancer is the most common endocrine malignancy 1 and accounts for most of the overall increase in cancer incidence among adolescents and young adults aged 18 to 35 years at diagnosis. 2 It is the second most frequently diagnosed cancer in women and the eighth in male adolescents and young adults.…”

Section: Introductionmentioning

confidence: 99%

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

et al. 2018

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“…Thyroid carcinoma (TC) is the most common endocrine malignancy accounting for >90% of malignancies of endocrine glands ( 1 ). Worldwide, the incidence of TC has increased, which can be explained by the more intensive use of imaging modalities that increased the detection of small, non-symptomatic tumors ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives

et al. 2015

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Thyroid cancer is the most common endocrine malignancy. Despite having a good prognosis in the majority of cases, when the tumor is dedifferentiated it does no longer respond to conventional treatment with radioactive iodine, the prognosis worsens significantly. Treatment options for advanced, dedifferentiated disease are limited and do not cure the disease. Autophagy, a process of self-digestion in which damaged molecules or organelles are degraded and recycled, has emerged as an important player in the pathogenesis of different diseases, including cancer. The role of autophagy in thyroid cancer pathogenesis is not yet elucidated. However, the available data indicate that autophagy is involved in several steps of thyroid tumor initiation and progression as well as in therapy resistance and therefore could be exploited for therapeutic applications. The present review summarizes the most recent data on the role of autophagy in the pathogenesis of thyroid cancer and we will provide a perspective on how this process can be targeted for potential therapeutic approaches and could be further explored in the context of multimodality treatment in cancer and personalized medicine.

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“…A limitation of this study is the small sample size, due to the rarity of this pathology [1], yielding wide confidence intervals that hinder statistically significant results. Control data were obtained from a previous study using Italian cohorts.…”

Section: Discussionmentioning

confidence: 99%

“…Sporadic carcinoma of the parathyroid glands is an extremely rare malignancy, accounting for an estimated 0.005% of all cancer cases, with two new cases per 10,000,000 person-years [1]. The rarity of this disease presents a challenge in studying its underlying pathophysiological and molecular features.…”

Section: Introductionmentioning

confidence: 99%

Specifying the molecular pattern of sporadic parathyroid tumorigenesis—The Y282D variant of the GCM2 gene

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Herten

et al. 2017

Biomedicine & Pharmacotherapy

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Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. The present study investigated the prevalence of the Y282D variant of the GCM2 gene and its association with clinical parameters in patients with a definitive histological diagnosis of sporadic parathyroid carcinoma (SPC) or atypical adenoma (AA).

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Carcinoma of endocrine organs: Results of the RARECARE project

Cited by 44 publications

References 26 publications

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives

Specifying the molecular pattern of sporadic parathyroid tumorigenesis—The Y282D variant of the GCM2 gene

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