Carcinoma mioepitelial de glándula submaxilar. Caso clínico y revisión de la literatura

Bascones, Alejandro Encinas; Adam, Natalia Escribano; Sen, Oscar de la; Falahat, Falahat; Martı́n-Granizo, R.; Berguer, A.

doi:10.1016/j.maxilo.2014.06.004

Cited by 1 publication

(12 citation statements)

References 22 publications

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“…Most MCs develop secondary to a pleomorphic adenoma or a preexisting benign myoepithelioma, generating a low-grade neoplasm. When they appear de novo, as in our case, they are usually high grade with a tendency towards clinical and radiological aggressiveness, in addition to a short evolution time [ 1 , 9 , 10 , 12 ]. A large clinical series reports that 75% of the MCs appear as “de novo” and 25% come from a previous benign tumor; other authors describe 50:50 ratios and even as low as 30% de novo MC [ 2 , 7 , 9 ].…”

Section: Discussionmentioning

confidence: 80%

“…These tumors occur in both sexes, with some reports of slight female predominance. They may occur at any age, but more frequently in the 5th–6th decades of life (range 14–77 years; mean 61.7 years) [ 1 , 2 , 4 ]. On the other hand, in the pediatric population, the real frequency of these tumors is unknown; however, the same proportion of benign and malignant myoepitheliomas has been suggested [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…MC usually presents as a painless swelling, but more frequently with additional symptoms compared to benign ones such as long evolution, rapid growth, pain (10–29%), facial paralysis (10–15%), numbness of the tongue or lips, dysphagia, stone consistency, fixation to deep structures, and pathological lymphoid nodules [ 1 , 9 , 10 ]. In our case, the patient presented with an increase in the volume of the parotid region that was painful and fixated to deep structures, which strongly oriented towards a malignant character.…”

Section: Discussionmentioning

confidence: 99%

“…Myoepithelial carcinoma (MC) is a rare neoplasm, almost exclusively composed of tumor cells with myoepithelial differentiation, without evident ductal differentiation and clear tumor infiltration in adjacent tissues [ 1 , 2 ]. Myoepithelial cells are specialized basal cells that occur in the epithelium of various organs, including the salivary glands, respiratory tract, breast, and sweat glands.…”

Section: Introductionmentioning

confidence: 99%

“…Malignant myoepithelioma represents 1–2% of all salivary gland neoplasms and 1.2–1.5% of all carcinomas. It arises mainly from the major salivary glands, most frequently in the parotid gland, and shows an infiltrative growth pattern towards the adjacent tissues [ 1 , 2 , 4 ]. In the pediatric population, salivary gland neoplasms are rare, with an overall incidence of 3–4 cases per 10,000, corresponding to <5% of salivary gland tumors and <2% of head and neck tumors [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Parotid Myoepithelial Carcinoma in a Pediatric Patient with Multiple Recurrences: Case Report

Thompson

Law²,

Vasquez³

et al. 2021

Case Rep Oncol

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Myoepithelial carcinoma of the salivary glands is a rare entity, with scarce amount of case reports in the literature. Due to its infrequency, its diagnosis is usually difficult and uncertain. Although there are reports of locoregional recurrences and distant metastases, its low incidence and varied biological behavior limits the clinical evidence that can be used to predict the prognosis and determine the course of treatment. We present a 23-year-old female patient without past medical history with an initial 1-year history of volume increase in the right parotid region of tumor aspect and painful on palpation. As a malignancy was suspected, a total parotidectomy was performed, reporting in the deep lobe a parotid myoepithelial carcinoma with vascular and neural invasion, negative borders, and 3–9 negative regional nodes. During her 16-year clinical evolution, she presented approximately every 2 years and a total of 9 locoregional recurrences and hepatic metastases, including cervical lymphoid nodules, temporal bone, frontal bone, and temporal fossa. Those recurrences have been treated with coordinated efforts between repeated external radiotherapy, chemotherapy, and multiple surgical resections. Myoepithelial tumors represent only 1.0–1.5% of all salivary gland tumors. The literature reports suggest a high incidence of locoregional recurrences and distant metastases in de novo myoepithelial carcinomas. Due to its rarity, treatment continues to be based on the experience of medical staff.

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