Carcinoma metastatic to the eye and orbit. III. A clinicopathologic study of 28 cases metastatic to the orbit

Abstract

Two hundred and twenty-seven cases of carcinoma metastatic to the eye and orbit have been reviewed previously. The orbit alone was involved in 28 cases: theses lesions constitute the basis of this clinicopathologic study. The most common signs and symptoms produced by orbital metastasis included exophthalmos (75%1, pain (29%), decreased vision (29%), periorbital swelling (25%), a visible mass (21%), ophthalmoplegia, and diplopia (18%). The ophthalmologists' preoperative (or premortem) clinical diagnoses were: orbital mass, 36%; metastatic carcinoma, 29%; leukemia, 7%; melanosarcoma, 4%; mixed tumor of lacrimal gland, 4%; and meningioma, 4%. The sites of the primary tumors in the 28 patients with orbital metastasis were as follows: breast, eight; lung, four; genitourinary tract, four; pancreas, one; and ileum, one. In 10 patients the site of the primary carcinoma was not determined. In 17 of the 28 patients, symptoms of orbital metastasis preceded detection of a primary tumor elsewhere in the body. In 10 of the remaining 11 patients, detection of the primary tumor had preceded the onset of orbital symptoms. In one patient, symptoms of the primary tumor and of orbital metastasis appeared at about the same time. The median survival of patients with carcinoma metastatic to the orbit was 15.6 months from the time of orbital surgery. This was much better than the median survival of the 227 patients in the overall study (7.4 months) and far better than the median survival of the patients with metastasis to the anterior segment of the eye (only 5.4 months).

Transitional carcinoma with extensive invasion of the bony orbit in a dog

“…It is often necessary to perform regional radiography, CT scans and ultrasonography to properly investigate possible invasion into the nasal cavity, paranasal sinuses, retrobulbar space and oral cavity (Font and Ferry, 1976;Hendrix and Gelatt, 2000;Turek and Lana, 2007). A CT scan is an excellent method to demonstrate mass effect, opacification and bone destruction (Le Blanc and Daniel, 2007).…”

Orbital Metastasis An Analysis of Nine Cases And Review of Literature

“…[1] Front and Ferry, in a series reported from national pathology registry, noted that 17 of 28 patients (61%) presented with orbital metastasis with unknown primary. [1,2] Most common causes of metastasis to orbit are breast, prostate, lung and kidney; they make 60-70% of all cases metastasizing to orbit; other causes of orbital metastasis have been reported in various tumor located at different sites such as skin, stomach, bone, pleura, gall bladder and testis. [1,3,6] In our study four patients (44.4%) had adenocarcinoma, two patients (22.2%) had adenoid cystic carcinoma of salivary glands and one patient (11.1%) each had malignant lymphoma, osteosarcoma and papillary carcinoma thyroid in histopathology.…”

“…[1] These metastatic deposits may precede symptoms of primary in many cases like in lung, gastrointestinal, thyroid and renal cancers. [2,3]Some cases of carcinoma breast present with orbital metastasis after completing treatment for the primary. [2,3] Now a day evaluation for unknown primary in case of metastases is relatively easy with advancement in technology.…”

“…[2,3]Some cases of carcinoma breast present with orbital metastasis after completing treatment for the primary. [2,3] Now a day evaluation for unknown primary in case of metastases is relatively easy with advancement in technology. Nevertheless, in some cases the primary remains unknown until the tumor present as metastasis elsewhere.…”

Metástasis orbitarias: Serie de cuatro casos y revisión de la literatura

“…The fact that 50% of cases with orbit metastases visit their ophthalmologist without even knowing about the existence of a primary tumor (2) emphasizes the role played by this specialist in the diagnosis of this pathology. Adult males and children frequently are not aware of the existence of a primary tumor (3)(4)(5)(6)(7)(8) when orbit metastasis appears.…”