Carcinoma in situ of the vagina

Cytopathological Findings on Vaginal Papanicolaou Smears after Hysterectomy for Benign Gynecologic Disease

“…[6][7][8][9] Dysplasia or carcinoma of the cervix is the most common predisposing factor for the development of both vaginal carcinoma in situ and invasive vaginal carcinoma, 1,3,7,10-12 and both are very rare in women with no history of cervical disease. 1,5,7,8 Risk factors for vaginal dysplasia or carcinoma after hysterectomy for benign gynecologic disease may include older P age, 2 a relatively high number of sexual partners, 11 low socioeconomic status, 11 human papillomavirus infection, 11 and immunosuppression. 13 The Papanicolaou smear has been widely used to screen for carcinoma of the cervix for over 40 years.…”

“…Until more data are available, routine vaginal Papanicolaou smears should be considered only for women with a history of cancer of the genital tract or cervical intraepithelial neoplasia type III (carcinoma in situ) because of their increased risk for disease. 5,7,[18][19][20]25 …”

The management of the patient with abnormal vaginal cytology following hysterectomy

“…Several authors have produced data which support a multicentric origin of dysplastic disease of the cervix, vagina and vulva (Ferguson & Maclure 1963;Woodruff 1965;Hummer et al 1970;Hammond & Monaghan 1983). Wade-Evans (1976) stated 'a histologically and cytologically normal epithelium at the edge of a demonstrably dysplastic area already carries within it seeds of further malignancy .…”

Vulva and Vagina

“…215 Discovery of the lesions is usually preceded by, or coincident with, cervical or vulvar squamous neoplasia. The mean age of patients with VAIN 3 is approximately 53 years, 10 years older than the mean age of patients diagnosed with CIN 3 at the same institution.…”