Carcinoma in a Mixed Mammary Tumor in a Llama <i>(Lama Glama)</i>

Bangari, Dinesh S.; Stevenson, Gregory W.

doi:10.1177/104063870701900423

Cited by 10 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, only one description of bone metaplasia is available for this group, associated, however, with severe skin lesions in a dolphin found entangled in fisher nets ( St. Leger et al, 2018 ). Bone metaplasia in mammals is mainly caused by tumors ( Kornegay et al, 1991 ; Sant'Ana et al, 2002 ; Bangari and Stevenson 2007 ; Kannegieter et al, 2010 ; Ramirez et al, 2010 ; Ohfuji 2012 ), followed by metabolic and eating disorders ( Han and Gardiner, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

First report on Phyllobothrium delphini infection and Crassicauda sp. parasitism resulting in osseous metaplasia in a Cuvier's beaked whale (Ziphius cavirostris) from the Brazilian region

Jerdy¹,

Werneck²,

Barbosa³

et al. 2022

International Journal for Parasitology: Parasites and Wildlife

View full text Add to dashboard Cite

A female Cuvier's Beaked Whale ( Ziphius cavirostris ) specimen measuring 580 cm in length died after being stranded in Southeastern Brazil. Following a necropsy, organ samples were obtained, fixed in 10% neutral buffered formalin and histopathologically analyzed. A severe and generalized hypodermis infection by Phyllobothrium delphini (Phyllobothriidae) was observed, resulting in granulomatous panniculitis. Severe renal and arterial lesions were also noted, including a severe bone metaplasia in the aorta artery, associated with a massive infection by Crassicauda sp, (Tetrameridae). A significant thoracic hemorrhage due to thoracic aorta artery rupture was noted, also likely due to this infection, resulting in a fatal injury. This study contributes towards knowledge on histopathologic changes in the scarcely studied Cuvier's Beaked Whale, is the first to associate a Crassicauda sp. infection in this whale species in the Brazilian region and also the first to indicate a resulting osseous metaplasia due to this parasitism and granulomatous dermatitis associated with Phyllobothrium delphini . Furthermore, this is also, to the best of our knowledge, the first report of Phyllobothrium delphini cysts in a Ziphius cavirostris specimen to date.

show abstract

Section: Discussionmentioning

confidence: 99%

First report on Phyllobothrium delphini infection and Crassicauda sp. parasitism resulting in osseous metaplasia in a Cuvier's beaked whale (Ziphius cavirostris) from the Brazilian region

Jerdy¹,

Werneck²,

Barbosa³

et al. 2022

International Journal for Parasitology: Parasites and Wildlife

View full text Add to dashboard Cite

show abstract

“…Neoplastic cells had distinct cell borders and scant, pale eosinophilic and occasionally finely vacuolated cytoplasm. The nuclei were round-to-oval with finely stippled chromatin and 1–4 nucleoli and moderate anisokaryosis; 8 mitotic figures were counted in 2.37 mm 2 (10 high power fields, 40× objective). Some lymphatics and blood vessels contained emboli of neoplastic cells.…”

mentioning

confidence: 99%

Fatal septicemia in 2 South American camelids with caudal C3-pyloric-duodenal adenocarcinoma

Abad,

Fritz,

Gonzales-Viera

2024

J VET Diagn Invest

View full text Add to dashboard Cite

Gastrointestinal adenocarcinomas are often reported in South American camelids (SAC). We describe here cases of gastroduodenal adenocarcinoma in an adult alpaca ( Vicugna pacos) and a llama ( Llama glama); both SACs were anorectic and lethargic before death. At autopsy, a prominent and firm caudal C3-pyloric-duodenal junction with stricture and ulceration was present in both animals, as were hemorrhages in various organs and hydrothorax. Microscopically, scattered nests, cords, and tortuous acini of neoplastic epithelial cells were embedded in desmoplastic stroma and invaded the submucosa and muscle layers of the gastroduodenal junction. The mucosa was necrotic, with gram-negative rods in the alpaca and colonies of gram-positive cocci in the llama. No tumor metastases were observed. The neoplastic cells immunolabeled for pancytokeratin. Escherichia coli was isolated from the alpaca and Streptococcus lutetiensis from the llama; septicemia was the cause of death in both animals. Although adenocarcinomas arising from gastric compartments and intestinal segments have been reported in SACs, adenocarcinoma of the caudal C3-pyloric-duodenal junction has not been reported previously in these species, to our knowledge.

show abstract

“…19 In addition to bile duct carcinoma, other tumors that have been reported in llamas include metastatic pulmonary adenocarcinoma, 15 metastatic uterine adenocarcinoma, 9 malignant round cell neoplasia, 12 cutaneous metastases of a mammary carcinoma, 10 gastric squamous carcinoma, 18 retinoblastoma, 3 gemistocytic astrocytoma, 4 and carcinoma in a mixed mammary tumor. 2 Cholangiocellular carcinomas are malignant neoplasms of biliary epithelium, which usually arise from the intrahepatic ducts, but also extrahepatic bile ducts can be affected. Such neoplasms have been recorded in dogs, cats, cattle, sheep, and horses but less frequently than hepatocellular tumors.…”

Section: Panopticmentioning

confidence: 99%

mentioning

confidence: 99%

Metastatic cholangiocarcinoma in a llama (Lama glama)

Taulescu

Bolfă²,

Buiga³

et al. 2012

J VET Diagn Invest

View full text Add to dashboard Cite

A 2-year-old female llama (Lama glama) from a private zoological park was submitted to the Pathology Department of the Faculty of Veterinary Medicine from Cluj-Napoca (Romania) for necropsy. The animal had a history of depression, anorexia, progressive weakening, ataxia, decubitus ulcers, fever, dyspnea, and abdominal distension. Death occurred 6 weeks after the onset of clinical signs. Necropsy, and cytological, histological, and immunohistochemical examinations were performed. Grossly, the animal was emaciated. Subcutaneous edema of the posterior limbs, abdomen, and thorax, hydrothorax, hydro-pericardium, and severe ascites (approximately 15 liters of fluid) with fibrin clots adherent to the visceral peritoneum, and multiple, acute, gastric ulcers were observed.A firm, white-gray, multinodular mass, 25 cm in diameter was found in the liver parenchyma. Moreover, multiple small nodules, unencapsulated, with poorly defined margins, and ranging from 0.5 to 4 cm in diameter scattered throughout the liver parenchyma were present. The cut surface of the tumors varied from gray-white to red-brown (Fig. 1). Multiple areas of necrosis, a few microabscesses, and venous thrombosis were also found within the liver parenchyma. Similar nodular lesions affecting the mesenteric, tracheobronchial, and submandibular lymph nodes, lungs (Fig. 2), parietal pleura, pericardium, diaphragm, the serosal surface of the gut, and peritoneum were present. Lesions were umbelicated, firm, and gray, and ranged from 0.5 to 3 cm in diameter. The lymph nodes were markedly enlarged and multifocally replaced by metastatic lesions. No tumors were detected in other organs, including kidney, stomach, pancreas, and mammary glands.Samples from liver, lung, lymph nodes, diaphragm, and pericardium were evaluated by cytological, histological, and immunohistochemical examinations. For cytology, multiple smears from the hepatic masses were stained by Dia-Quick Panoptic.a For histology, the samples were fixed in 10% phosphate buffered formalin for 24 hr, embedded in paraffin wax, cut into 3-5 µm sections, and stained with hematoxylin and eosin and periodic acid-Schiff (PAS). Histological interpretation of lesions was done according to the World Health Organization Classification of Tumors of the Alimentary System of Domestic Animals.6 For immunohistochemistry, sections from liver mass, lung nodules, and normal liver and lung tissue (inner control) were selected. After dewaxing, heat-induced epitope retrieval pretreatment, and endogenous peroxidase inactivation (H 2 O 2 1% in phosphate buffered saline b [PBS]), slides were incubated with goat serum 10% in PBS for reducing background staining. Sections were incubated with the following mouse monoclonal primary antibodies: broad spectrum cytokeratins (panCK), c CK20, c CK19, c CK7, c thyroid transcription factor 1 (TTF1), c and carcinoembryonic antigen (CEA), b for 24 hr at 4°C. After washes, the secondary antibody (labeled streptavidin biotin) was applied, followed by incubation with diaminobenzidine. Negative...

show abstract

Carcinoma in a Mixed Mammary Tumor in a Llama (Lama Glama)

Cited by 10 publications

References 7 publications

First report on Phyllobothrium delphini infection and Crassicauda sp. parasitism resulting in osseous metaplasia in a Cuvier's beaked whale (Ziphius cavirostris) from the Brazilian region

First report on Phyllobothrium delphini infection and Crassicauda sp. parasitism resulting in osseous metaplasia in a Cuvier's beaked whale (Ziphius cavirostris) from the Brazilian region

Fatal septicemia in 2 South American camelids with caudal C3-pyloric-duodenal adenocarcinoma

Metastatic cholangiocarcinoma in a llama (Lama glama)

Contact Info

Product

Resources

About