Polyps of the vagina are benign, soft tissue tumors composed of loose connective tissue with myxoid changes and containing atypical, pleomorphic, hyperchromatic cells. Because of this bizarre microscopic configuration, they have been confused with sarcoma botryoides. Eighteen cases of polyps of the vagina included in the pathology files of Magee-Womens Hospital from 1972-1979 were compiled. Clinical and pathologic findings were reviewed. All patients except one were white, and median age was 48.5 years. The most common symptom was vaginal bleeding (ten patients) or vaginal "growth" (six patients). All lesions (except one in which only a biopsy was done) were treated with local resection.