Carcinoma gástrico asociado a otras neoplasias malignas primarias. Estudio retrospectivo de 25 casos

Jiménez, Alejandra; Bujanda, Luís; Pérez, E. Ojeda; Lasa, Inés Gil; Barrio, Jesús; Cadena, J. Torrado; Pérez, Antonio

doi:10.1016/s0014-2565(00)70543-1

Cited by 3 publications

(7 citation statements)

References 18 publications

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“…The treatment most frequently reported in our review, and which coincides with that we carried out in the present study, was the resection of both primary tumors at the same surgical time; the most commonly performed technique was partial gastrectomy with anastomosis and radical nephrectomy, since it has been shown to have a better prognosis and longterm survival in patients [37]. It is worth noting that the involvement of the left kidney (87.5%) was much more predominant than the right kidney in the articles included in our review [5,6,19,[22][23][24]. No cause or association can be concluded related to this finding.…”

Section: Discussionsupporting

confidence: 86%

“…Of the total number of cases reported in the literature with synchronous GC and kidney carcinoma, the highest prevalence was found in elderly patients (> 60 years), with males outnumbering females 2:1. The most commonly reported risk factor was smoking [2,4,17,18,20,[22][23][24][25]. The most frequent clinical presentations were upper or lower gastrointestinal (GI) bleeding, nonspecific Multiple combinations of surgical treatments are described, including partial gastrectomy/radical nephrectomy [5], subtotal gastrectomy/partial nephrectomy [6,19], total gastrectomy/radical nephrectomy [17,20], endoscopic gastric resection/radical nephrectomy [24], partial gastrectomy/total nephrectomy [17], mucosectomy/renal active surveillance [18], and total gastrectomy/renal active surveillance [22].…”

Section: Resultsmentioning

confidence: 99%

“…With regard to the management of patients with renal carcinoma, multiple reviews revealed that radical nephrectomy was the most frequently performed surgical intervention, followed by total nephrectomy, partial nephrectomy, and two cases treated with active surveillance. Diagnostic renal carcinoma was more frequently on the left side with nephrectomy (partial, total, or radical) [5,6,19,[22][23][24].…”

Section: Resultsmentioning

confidence: 99%

“…It was revealed that the most common histopathological findings of GC were described as poorly differentiated [2,4,20], moderately differentiated [19,22], and well differentiated [17,26], in that order of presentation. The findings in the group of patients with renal carcinoma were cell carcinomas [2,3,6,19,24] as the most frequent histopathological result, with other rare reported cases of chromophobe cell [5,20,23] and transitional cell carcinoma [2].…”

Section: Resultsmentioning

confidence: 99%

“…In our review we found that the risk factors with the greatest impact were chronic smoking and advanced age (over 60 years) [2,4,17,18,20,[22][23][24][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

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Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

et al. 2020

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Background Gastric carcinoma (GC) with second primary malignancy (SPM) is the most frequent combination within the multiple primary malignancies (MPM) group. The presentation of a GC associated with a synchronized SPM in the kidney is extremely rare and unusual. This study presents a rare case of synchronous tumors, describes the main associated risk factors, and emphasizes the need to rule out SPM. Main body We present the case of a 63-year-old Hispanic woman with a history of smoking, weight loss, and gastrointestinal (GI) bleeding. GC was diagnosed by endoscopy, and during her workup for metastatic disease, a synchronous SPM was noted in the left kidney. The patient underwent resection of both tumors with a satisfactory postoperative course. A systematic review of the literature was performed using the Medline/PubMed, Science Direct, Scopus, and Google Scholar databases. A search of the literature yielded 13 relevant articles, in which the following main risk factors were reported: the treatment utilized, the grade and clinical stage, histopathological report, and in some cases survival. It is concluded that advanced age (> 60 years) and smoking are the main associated risk factors. Conclusion Gastric carcinoma is the second most frequent neoplasm of the GI tract and the main neoplasm that presents a SPM. MPM screening is recommended in patients with gastric cancer. The clinical discovery of MPM of renal origin is rare and hence the importance of the current report.

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Section: Discussionsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…In our review we found that the risk factors with the greatest impact were chronic smoking and advanced age (over 60 years) [2,4,17,18,20,[22][23][24][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

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Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

et al. 2020

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Risk and prediction of multiple primary malignancies after early gastric cancer

Chen¹,

Shi²,

Ge³

et al. 2023

Front. Oncol.

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BackgroundPatients with early gastric cancer have increased risk of developing multiple primary malignancies (MPM) due to improved survival rates. The purpose of this study was to evaluate the clinicopathological features of MPM and to generate a useful tool for predicting the development of MPM after early gastric cancer.MethodsWe selected 1025 early gastric cancer patients with complete medical records for a retrospective analysis. The Cox proportional risk regression model was used to analyze the independent risk factors for the development of MPM in early gastric cancer. RStudio software was used to compare the OS of early gastric cancer patients with and without MPM, and a nomogram was established to predict the probability of MPM 1-, 2-, 3-year after early gastric cancer. The predictive effectiveness of the nomogram was evaluated by the C-index and calibration curve. Decision curve analysis (DCA) measured the applicability of the nomogram to clinical practice.ResultsOf the 1025 patients with early gastric cancer, 66 patients (6.4%) had 69 primary cancers other than early gastric cancer. They had a median follow-up of 41 months, and their cumulative incidence of MPM was 4.9%, 5.4% and 5.9% after 1-, 2-, and 3- year, respectively. Oesophageal cancer was the most frequently detected MPM, followed by lung and colorectal cancers. Male (p=0.038), age ≥65 years (p=0.003), smoking history (p=0.036), and lymph node metastasis (p=0.013) were independent risk factors for MPM in patients with early gastric cancer. Patients with early gastric cancer with MPM had a worse OS prognosis than patients with early gastric cancer without MPM (p<0.001). The internally validated nomogram predicted the probability of developing MPM after early gastric cancer (C index= 0.697). The calibration chart showed that the predicted probability of MPM in early gastric cancer was similar to the observed result, and the DCA showed strong clinical practicability.ConclusionAfter the diagnosis and treatment of early gastric cancer, we should be alert to the possibility of MPM and perform regular and careful monitoring.

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Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

Muela-Molinero

Plaza

Arino

et al. 2006

Rev. esp. enferm. dig.

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Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.

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Carcinoma gástrico asociado a otras neoplasias malignas primarias. Estudio retrospectivo de 25 casos

Cited by 3 publications

References 18 publications

Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

Gastric carcinoma and renal cell carcinoma as an atypical presentation of multiple primary malignancies: a case report and review of the literature

Risk and prediction of multiple primary malignancies after early gastric cancer

Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

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