Carcinoma ex-pleomorphic adenoma of submandibular salivary gland: A case report and review of literature

Bhat, Vadisha Srinivas; Kolathingal, Biniyam; Aziz, Ajaz Abdul; Yeshwanth, Sunil Kumar

doi:10.4103/2277-8632.215518

Cited by 2 publications

(2 citation statements)

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“…PA with hyalinisation is usually the turning point condition into premalignancy. 15,18 We also observed a high level of mitotic cells in one case of PA samples, even though it was not as high as the CXPA (Figure 4). From all the PA samples, only three cases (12.5%) of atypical appearance were observed as similar to CXPA appearance, such as mitotic figure appearance, squamous metaplasia with keratin pearls, nuclear pleomorphism and capsule infiltration (pseudopodia).…”

Section: Discussionmentioning

confidence: 74%

Progressivity analysis of pleomorphic adenoma toward carcinoma ex pleomorphic adenoma

et al. 2022

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Background: Pleomorphic adenoma (PA) is a benign salivary gland tumour with high incidence and recurrence after treatment. It may recur with the same appearance or develop toward malignancy, namely as carcinoma ex pleomorphic adenoma (CXPA). Howthis tumour can transform into a CXPA remains unclear. Purpose: The aim of this study was to analyse the possibility of pathogenesis and progressivity of PA to CXPA. Methods: Twenty-four samples of PA and three control samples of CXPA were stained with haematoxylin and eosin (HE), Mallory’s trichrome, and Periodic acid–Schiff (PAS). All of the PA cases were identified through different kinds of stroma, tumour cells types, morphologic patterns, or else through atypical appearance of the PA similar to the CXPA. Results: Twenty-four samples of PA demonstrated that the most dominant stroma was myxofibrous, and the dominant tumour cell type was plasmacytoid cells with a trabecular pattern. Additionally, in the pleomorphic histological picture of adenomas we found several patterns of malignant tumour behaviour, including pseudopodia, metaplasia and hyalinisation, and cholesterol crystals that are thought to come from fat cell necrosis derived from adipose metaplasia. Conclusions: PA displays several atypical characteristics that have the potential to develop into malignancies such as CXPA, due to capsular infiltration, necrosis, hyalinization and high mitotic activity of cells, but all these atypical characteristics that we observed still cannot be clearly classified as CXPA because they require other specific examinations.

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Section: Discussionmentioning

confidence: 74%

Progressivity analysis of pleomorphic adenoma toward carcinoma ex pleomorphic adenoma

et al. 2022

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“…Carcinoma ex pleomorphic adenoma (Ca ex PA, CXPA) is type of rare, aggressive, poorly understood malignancy usually occurring in the salivary glands and accounts for most cases of malignant mixed tumors reported in the literature. [1][2][3] It is also known as carcinoma ex mixed tumor, carcinoma ex adenoma, and carcinoma ex benign pleomorphic adenoma. 4 It was first described by Beahrs et al in 1957 and accounts for 3.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of Carcinoma ex Pleomorphic Adenoma

Grewal¹,

Singh²,

Bhagat³

2018

IHRJ

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Carcinoma ex-pleomorphic nonmalignant tumour (Ca ex PA, CXPA) is a rare, aggressive, poorly understood malignancy of the exocrine gland. The clinical findings typical of this neoplasm embrace history of a slow growing, ulcerated, painless mass that enlarges speedily. The current definition of Ca ex PA became widely accepted in the second half of the twentieth century. It is uncommon, having a prevalence rate of 5.6 cases per 100,000 malignant neoplasms and a yearly incidence rate of 0.17 tumours per 1 million persons in the world. The cancer is found predominantly in the sixth to eighth decades of life and is slight female predilection.

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Carcinoma ex-pleomorphic adenoma of submandibular salivary gland: A case report and review of literature

Cited by 2 publications

References 1 publication

Progressivity analysis of pleomorphic adenoma toward carcinoma ex pleomorphic adenoma

Progressivity analysis of pleomorphic adenoma toward carcinoma ex pleomorphic adenoma

A Case Report of Carcinoma ex Pleomorphic Adenoma

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