Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma

Mitate, Eiji; Kiyoshima, Tamotsu; Kawazu, Toshiyuki; Chikui, Toru; Goto, Yuichi; Matsubara, Ryota; Nakamura, Seiji

doi:10.1186/1477-7819-11-234

Cited by 12 publications

(8 citation statements)

References 7 publications

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“…Post-op radiotherapy was usually used for CXPA with advanced stage, high histological grade, node and perineural involvement while surgery alone may be therapy option for small carcinomas. 11 , 16 …”

Section: Discussionmentioning

confidence: 99%

Rare Carcinoma Ex-pleomorphic Adenoma of Buccal Mucosa: Case Report and Review of Literature

et al. 2016

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Carcinoma ex pleomorphic adenoma (CXPA) is exceedingly rare in minor salivary glands of oral cavity. We present a case of CXPA arising from buccal mucosa in a 44-year-old male patient. The man presented to surgery outpatient department with right buccal mucosa swelling. Clinical impression suggests a neoplasm of buccal mucosa and the patient was sent for fine needle aspiration cytology. By examining the cytological smears, possibility of carcinoma was revealed. The mass was dissected and excised with safety margins. Examining Hematoxylin and Eosin slides, final diagnosis of CXPA was given. Patient did not turn for regular follow-ups and presented 1 year after surgery with recurrence at the same site. CXPA is an uncommon malignant tumor with highly aggressive biological behavior. Its occurrence in sites like buccal mucosa is rare. Hence, quite a diagnostic challenge at such sites cause diagnostic difficulties.

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Section: Discussionmentioning

confidence: 99%

Rare Carcinoma Ex-pleomorphic Adenoma of Buccal Mucosa: Case Report and Review of Literature

et al. 2016

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“…Frequent malignant changes reported were adenocarcinoma and salivary duct carcinoma (Olsen and Lewis, 2001). Additionally, a case of squamous cell carcinoma ex-PA on the upper lip was previously reported (Mitate et al, 2013). At the molecular level, a subset of this tumours was found to demonstrate the expression of PLAG1, HMGA2 fusions and downregulation of WIF1 which implicates malignant transformation.…”

Section: Ethical Considerationmentioning

confidence: 91%

“…This subset of tumour mainly arises from major salivary glands, mostly parotid, followed by submandibular glands (Antony et al, 2012). Nevertheless, these occurrences of malignant transformation were reported in PA arising from minor salivary glands mostly on the hard and soft palate (Yoshihara et al, 1995;Damm and Fantasia, 2001) and around 10.5% affects the upper lip (Ellis and Auclair, 2008;Mitate et al, 2013;Sedassari et al, 2014). Due to the long-standing nature of the transformation, it is rarely encountered in children (Lack and Upton, 1988) and more commonly seen in patients in the sixth and seventh decade of life (Olsen and Lewis, 2001).…”

Section: Benign Mesenchymal Tumoursmentioning

confidence: 99%

Pleomorphic Adenoma of the Upper Lip: A Rare Presentation in a Young Boy and Differential Diagnosis

Mamat¹,

Rahman²

2020

AOS

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Pleomorphic adenoma is the most common benign salivary gland tumours affecting the parotid glands of the adult population. It has significant female gender predilection (F:M = 2:1) of the 20-60 years age groups and commonly presented as a painless unilateral slow-growing swelling over the preauricular area (Bell et al., 2017). Clinically, the eversion of the earlobe on the affected sides, when examined from behind, was one of the key clinical signs elicited, as the tumour mostly arises from the superficial lobe of the parotid glands. The occurrence of this neoplasm arising from a minor salivary gland on the upper lip of a male child under five years old is very uncommon (Ogata et al., 1994). Only a handful of cases reported in individuals less than 20 years old with the common intraoral site at the palate, cheek, upper and lower lips (

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“…Carcinoma ex pleomorphic adenoma (CXPA) constitutes about 12% of all SGMs, with the majority of cases arising from the parotid gland (67%) [ 2 ]. Histopathologically, poorly differentiated adenocarcinoma and undifferentiated carcinoma are the most frequently encountered malignant components of CXPA with squamous cell carcinoma (SCC) being a rare finding [ 3 , 4 ]. Metastatic SGMs are an uncommon finding with only 20% of parotid gland malignancies showing metastatic potential [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

Umar¹,

Ilyas²,

Alshamam³

et al. 2022

Cureus

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Cancer is a major cause of morbidity and mortality worldwide, with squamous cell carcinoma (SCC) being the most common type. Even though SCC is the major type of cancer found in the head and neck region, the salivary glands contribute to about 1/20 cases, of which 1/10 are said to be carcinoma ex pleomorphic adenoma (CXPA) type, and the parotid gland is found to be the most common origin of such cases. Although it usually arises later in life, it can grow rapidly, with local symptoms being late findings, if any. Even though fine needle aspiration cytology has low sensitivity for diagnosing such cancer, multiple/repeated biopsies can increase the yield and the accuracy of the test. Surgical resection is the main choice for treatment with postoperative radiation for select cases. Our case presented with CXPA with distant metastasis to multiple sites.

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Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma

Cited by 12 publications

References 7 publications

Rare Carcinoma Ex-pleomorphic Adenoma of Buccal Mucosa: Case Report and Review of Literature

Rare Carcinoma Ex-pleomorphic Adenoma of Buccal Mucosa: Case Report and Review of Literature

Pleomorphic Adenoma of the Upper Lip: A Rare Presentation in a Young Boy and Differential Diagnosis

Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland: A Rare Case

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