Carcinoma Ex Pleomorphic Adenoma

Hellquist, Henrik B.; Skálová, Alena

doi:10.1007/978-3-540-46915-5_10

Cited by 2 publications

(3 citation statements)

References 79 publications

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“…Pleomorphic adenoma (PA) is the most common benign salivary gland neoplasm and malignant transformation has been reported in 5% to 15% of cases. [ 26 ] Though multiple carcinoma subtypes and marked stromal hyalinization strongly suggest the possibility of carcinoma ex-pleomorphic adenoma (CA-ex-PA), but these features are not specific for a definitive diagnosis. A reliable marker for CA-ex-PA may be a valuable ancillary tool.…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

“…The PLAG1 (pleomorphic adenoma gene 1) is the target gene and is consistently rearranged and over-expressed in PA with 8q12 t (3; 8) abnormalities. [ 25 26 28 ] PLAG1 is a developmentally regulated zinc finger gene that is not expressed in normal salivary gland parenchyma. The gene product is a nuclear protein that functions as a DNA binding transcription factor.…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

“…[ 28 ] HMGA2 (High Motility Group Protein 2) is another target gene in pleomorphic adenoma with rearrangement in the 12q13-15 region. [ 25 26 28 ] This gene encodes a small non-histone chromatin associated protein that can modulate transcription by altering the chromatin architecture. Two fusion genes HMGA2-NF1B (nuclear factor 1B gene) and HMGA2-FHIT (fragile histidine triad gene) have been identified in PA.…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

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Beta-catenin in disease

Prakash

Swaminathan

Nagamalini

et al. 2016

J Oral Maxillofac Pathol

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In continuation with the previous review on “β-catenin in health”, in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours. This review is based on a pubmed search of all the lesions included in the review.

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Section: Pleomorphic Adenomamentioning

confidence: 99%

Section: Pleomorphic Adenomamentioning

confidence: 99%

Section: Pleomorphic Adenomamentioning

confidence: 99%

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Beta-catenin in disease

Prakash

Swaminathan

Nagamalini

et al. 2016

J Oral Maxillofac Pathol

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Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

2016

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Salivary gland hybrid tumour, first described in 1996, is a very rare neoplasm for which exact morphological criteria have not been universally agreed upon. In contrast, the concept of high-grade transformation (HGT) in salivary neoplasms has been widely accepted during the last decade, and the number of reported cases is rapidly increasing. A review of the literature revealed 38 cases of hybrid tumour reported in 22 publications. During approximately the same time period, well over 100 cases of HGT in salivary neoplasms have been reported. There are important histological similarities between hybrid tumours and salivary tumours with HGT. In the latter, containing one tumour component of low-grade malignancy and the other of high grade, the two tumour components are not entirely separated and appear to originate in the same area. Virtually, all cases reported as hybrid tumour had no clear lines of demarcation between the two tumour types. We are inclined to suggest that most of the 38 cases of hybrid tumours described in the literature would today better be called tumour with HGT rather than hybrid tumour. The relative proportion of the two components may vary, and the high-grade component is sometimes very small, which emphasises the importance of very generous sampling of the surgical specimen. The molecular genetic mechanisms responsible for HGT, including what used to be called hybrid tumour, remain largely unknown. Abnormalities of a few genes (including p53, C-MYC, cyclin D1, HER-2/neu) have been documented. As insufficient data exist on gene abnormalities in these lesions, conclusions as to whether or not they have a common origin and which mechanisms are involved in transformation cannot be drawn. Due to the small number of cases reported, many of which lack follow-up details; indicators of prognosis of hybrid tumours are not available, but their behaviour seems to be similar to that of tumours with HGT, i.e. an accelerated aggressive course. HGT of salivary gland neoplasms greatly influences macroscopic and microscopic evaluation of the specimen but also, given the high incidence of metastases and morbidity, carries significant treatment implications.

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Carcinoma Ex Pleomorphic Adenoma

Cited by 2 publications

References 79 publications

Beta-catenin in disease

Beta-catenin in disease

Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

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