Carcinoma ex pleomorphic adenoma in a Brazilian population: clinico-pathological analysis of 38 cases

Mariano, Fernanda Viviane; Noronha, Ana Lúcia Francisco; Gondak, Rogério; Altemani, Albina; Almeida, Orlando José de; Kowalski, Luiz Paulo

doi:10.1016/j.ijom.2013.02.012

Cited by 45 publications

(33 citation statements)

References 27 publications

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“…In the current series, females were more affected than males, in accordance with other epidemiological studies of SGTs 22,23. CXPA arising from PA and the carcinomatous component is variable, although salivary duct carcinoma is one of the most observed histopathological malignant components of CXPA[22][23][24][25] as seen in the current 12 cases.Altemani et al16 showed that the malignant component of CXPA is composed of epithelial cells that arise in duct cell structures. Also, FASN was markedly strong in almost all cases of salivary duct carcinoma component, adenocarcinoma not otherwise specified component and two cases of myoepithelial carcinoma component.F I G U R E 5 (A) Strong expression of FASN in salivary duct carcinoma component of CXPA with staining intensity 3 and 95% of fraction of positive cells (200× original magnification).…”

supporting

confidence: 90%

Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma

Díaz¹,

Gondak

Martins

et al. 2019

J Oral Pathology Medicine

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Background Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki‐67, by immunohistochemistry on 29 carcinomas ex‐pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Results Ki‐67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki‐67. Conclusions The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki‐67 may be useful diagnostic markers for CXPA.

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supporting

confidence: 90%

Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma

Díaz¹,

Gondak

Martins

et al. 2019

J Oral Pathology Medicine

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“…5,9,11,13,15,16 In agreement with these previous reports, most cases of noninvasive CXPA in this study behaved in a benign manner, with no recurrence or regional or distant metastasis during the follow-up period; 1 patient died of multiple lung metastases after surgical excision of the primary lesion and 1 patient developed cervical metastasis, but remained disease free after treatment. Although 1 study found no cases of recurrence or death in patients with minimally invasive CXPA, 17 others have reported several cases of recurrence and death in patients with intracapsular or minimally invasive CXPA. [18][19][20] Various treatment modalities have been proposed for the treatment of CXPA, based on tumor location, surgical margin, lymph node involvement, and pathologic grade.…”

Section: Ye Et Almentioning

confidence: 85%

Carcinoma Ex Pleomorphic Adenoma: Is It a High-Grade Malignancy?

Gao

Mao

et al. 2016

Journal of Oral and Maxillofacial Surgery

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“…The malignant component varies in phenotype and aggressiveness, i.e., from SDC to adenocarcinoma NOS, myoepithelial carcinoma, EMC, or AdCC, among others, or even with combined morphologies [11,13,14,56].…”

Section: Pa and Its Progression: An Example Of Recurrent Genetic Altementioning

confidence: 99%

Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity

Rito¹,

Fonseca²

2017

Pathobiology

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Salivary gland tumor classification encompasses a vast list of benign and malignant neoplasms. Their morphological diversity is recognized not only between different entities but also within individual tumors. Tumor categories as described by the World Health Organization reflect, in part, a true genetic heterogeneity (e.g., translocations involving CRTC1 and CRTC3-MAML2 genes in mucoepidermoid carcinoma and MYB-NFIB fusion in adenoid cystic carcinoma). Carcinoma ex pleomorphic adenoma shows diversity in its histological appearance, but recurrent rearrangements on PLAG1 and HMGA2 are common to its benign precursor. More recently, new categories have been defined, like secretory carcinoma with the t(12;15) (p13;q25) ETV6-NTRK3 translocation and clear-cell carcinoma with EWSR1-ATF1 fusion. Recent studies on cribriform adenocarcinoma of minor salivary gland origin and epithelial-myoepithelial carcinoma point to a correlation with their morphological features. All of these advances show that the search of a histogenetic and genetic basis for salivary gland tumors is helping to clarify morphological categories and unraveling new ones. Nevertheless, currently morphology is still the hallmark of tumor classification and the gold standard. The therapeutic options for advanced tumors remain very limited but the discovery of translocation-generated gene fusions and increased knowledge of the genomic information of salivary gland tumors is creating opportunities for the development of specific targeted therapies.

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Carcinoma ex pleomorphic adenoma in a Brazilian population: clinico-pathological analysis of 38 cases

Cited by 45 publications

References 27 publications

Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma

Fatty acid synthase and Ki‐67 immunoexpression can be useful for the identification of malignant component in carcinoma ex‐pleomorphic adenoma

Carcinoma Ex Pleomorphic Adenoma: Is It a High-Grade Malignancy?

Salivary Gland Neoplasms: Does Morphological Diversity Reflect Tumor Heterogeneity

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