Carcinoma espinocelular cutáneo y papilomavirus (VPH)

Corbalán-Vélez, R.; Ruiz-Maciá, J.A.; Brufau, C.; Carapeto, F. J.

doi:10.1016/s0001-7310(07)70143-6

Cited by 35 publications

(9 citation statements)

References 136 publications

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“…[20] Furthermore, it has been proposed that HPV can initiate and promote some skin lesions to a point of no return and subsequently, become undetectable or possibly be removed by the immune system. [21]…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

et al. 2014

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Background:Papillomatosis is a known histopathologic pattern usually seen in human papillomavirus (HPV) infection and verruca vulgaris is the typical example. This pattern is also detected in some other benign cutaneous lesions such as nevus sebaceous (NS), seborrheic keratosis (SK), trichilemmoma (TL) and inverted follicular keratosis (IFK). The association between papillomatous lesions and HPV infection is questionable.Objective:The objective of this study was to investigate the presence of HPV deoxyribonucleic acid (DNA) in non-genital benign papillomatous skin lesions (NS, SK, TL and IFK) by polymerase chain reaction (PCR).Materials and Methods:A total of 100 specimens of non-genital NS, SK, TL and IFK were retrieved from archives of Dermatopathology Department of Razi Hospital, between 2003 and 2010. The conventional PCR using consensus GP5+/GP6+ primer and hydroxymethylbilane synthase gene as inner control was performed.Results:PCR for HPV DNA revealed no positive results in any of 28 seborrheic keratosis (SK), 28 nevus sebaceous (NS), 28 inverted follicular keratosis (IFK) and 13 trichilemmoma (TL) studied specimens.Conclusion:Papillomatosis is usually a characteristic pattern of HPV infection. However, we found no association between HPV infection and non-genital benign papillomatous lesions.

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Section: Discussionmentioning

confidence: 99%

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

et al. 2014

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“…Various risk factors have been implicated in the development of SCC including exposure to ultraviolet light, ionizing radiation, certain immunosuppressive therapies, and HPV infection [10–13]. There have been multiple studies regarding the risk of developing cutaneous SCC on areas previously exposed to therapeutic radiation in the treatment of acne, hemangiomas, and dermatitis [10].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, some studies have shown that UV radiation exposure can work synergistically with HPV in the oncogenesis of SCC [13]. There has been one report of the development of cutaneous SCC of the nipple in a patient irradiated for breast cancer.…”

Section: Discussionmentioning

confidence: 99%

A 55-Year-Old Man with Stage IV Squamous Cell Carcinoma of the Right Groin after External Beam Radiation for Testicular Cancer

Ibilibor

Wells

Kavuri

et al. 2014

Case Reports in Urology

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Treating testicular cancer with adjuvant radiation has been associated with a number of second malignancies affecting the genitourinary tract and retroperitoneal structures; however, there have been few reported cases of cutaneous second malignancies. We report the case of a man who developed stage IV squamous cell carcinoma (SCC) of a condyloma after orchiectomy and adjuvant radiation for testicular cancer. We also review relevant literature available to date. A 55-year-old Caucasian man presented to the hospital with a large growth at the right groin which had grown into his right thigh preventing ambulation. His past medical history was significant for right testicular cancer of unknown pathology treated with orchiectomy and adjuvant radiation twenty years ago. Punch biopsy of the lesion revealed superficially invasive squamous cell carcinoma. He underwent excision of the growth with subsequent Cisplatin, radiation boost, and Paclitaxel regimens. Despite an aggressive treatment regimen and an initial good response, the patient's cancer progressed requiring palliative care. It is unclear whether or not therapeutic radiation in this case promoted the conversion of the patient's condyloma to a malignant lesion. Further studies are required at this time to clarify the clinical implications of these findings.

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“…The presence of intense solar elastosis in all our cases and the location of the lesion on the face and neck would suggest a synergistic effect between solar radiation and HPV in the pathogenesis of these lesions [27, 28]. …”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, BD has been associated with mucous HPV subtypes, especially types 16, 18 and 31 [2,3,4, 25, 28]. The protein E7 of these mucous HPV subtypes would provoke alterations in the Rb gene; thus, activating p16 protein [27, 28]. In this way, BD has been described to be associated with oncogenic mucous HPV subtype, such as HPV-16, and to stain positively for p16 protein [29].…”

Section: Discussionmentioning

confidence: 99%

‘Bowenoid Wart’: Wart with Bowenoid Histological Changes?

et al. 2008

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Introduction: Cases of lesions that simulate Bowen’s disease have been previously described in the literature. Case Report: Nine exophytic verruca-like lesions with histological findings of Bowen’s disease (BD) are described. All cases had a rapid growth, and were located on the face and neck of elderly patients with chronic solar skin damage. We carried out p16 immunohistochemical staining using the immunoperoxidase technique, which was negative in all cases. Discussion: We think that these 9 lesions are only histologically mimicking BD, and could be a subtype of verruca (‘bowenoid wart’). These lesions could be provoked by nononcogenic human papillomavirus (HPV), as in other cases previously described. The p16 staining was negative in all cases, in contrast with most BD cases. It would be interesting to study whether positive p16 staining is related to oncogenic HPV, whereas negative p16 staining could be associated with low or nononcogenic HPV; thus, more studies are needed.

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Carcinoma espinocelular cutáneo y papilomavirus (VPH)

Cited by 35 publications

References 136 publications

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

A 55-Year-Old Man with Stage IV Squamous Cell Carcinoma of the Right Groin after External Beam Radiation for Testicular Cancer

‘Bowenoid Wart’: Wart with Bowenoid Histological Changes?

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