Carcinoma-associated retinopathy in a young teenager with immature teratoma of the ovary

Turaka, Kiran; Kietz, Daniel; Krishnamurti, Lakshmanan; Mitchell, Ellen; Scanga, Hannah L.; Fu, Valeria L. N.; Sylvester, Christin

doi:10.1016/j.jaapos.2014.03.007

Cited by 17 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The wound indicated the ocular presentation as an “alarm” for the clinician to think of more other life-threatening metastases from the primary tumor. The blurred vision related to metastasis from ovary carcinoma can be due to choroidal mass causing neurosensory detachment or cancer-related retinopathy, as well as cancer-related optic neuropathy [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Choroidal mass secondary to mucinous cystadenocarcinoma of ovary in a young woman: a life-threatening metastasis

Shariff

Teo

Hitam³

2021

rjo

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Choroidal mass secondary to mucinous cystadenocarcinoma of ovary in a young woman: a life-threatening metastasis

Shariff

Teo

Hitam³

2021

rjo

View full text Add to dashboard Cite

“…Of note, CAR patients in this study were treated similarly to npAIR patients with systemic immunosuppressive therapy. This therapeutic approach has been used in the literature by various centers successfully, 31 , 32 , 37 – 40 but there is a risk with this approach of unmasking immunological control of their cancer. Therefore, we always discuss this risk with the patient and their oncologist before beginning systemic immunosuppressive therapy.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Immunological Markers with Disease and Clinical Outcome Measures in Patients with Autoimmune Retinopathy

Stanwyck

Chan

Sood

et al. 2020

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

To determine if immunological markers (1) are significantly different between autoimmune retinopathy (AIR) patients and controls and (2) correlate with disease progression in AIR patients. Methods: We enrolled patients with a possible AIR diagnosis, as well as control participants without eye disease, autoimmunity, or cancer. Immunological markers were tested in all participants. In addition, AIR patients had up to three blood draws for testing over their disease course. For AIR patients, clinical measures, including visual acuity (VA) and Goldmann visual field (GVF) area, were recorded at each draw. We used the Mann-Whitney U test to compare the immunological markers between AIR patients and controls. We used multilevel mixed-effect regression to investigate the correlation between markers and clinical parameters over time in AIR patients. Results: Seventeen patients with AIR and 14 controls were included. AIR patients had a higher percent of monocytes (Z = 3.076, P = 0.002). An increase in immunoglobulin G against recoverin was correlated with a VA decrease (β = 0.0044, P < 0.0001). An increase in monocyte proportion was correlated with a decrease in GVF area (β = −7.27, P = 0.0021). Several markers of B-cell depletion were correlated with GVF improvement. Conclusions: Monocytes may play a role in AIR pathophysiology and be a disease activity marker. B-cell depletion markers correlated with clinical parameter improvement, particularly GVF. Translational Relevance: This work elucidates immunologic markers that may improve the accuracy of diagnosis and treatment of AIR.

show abstract

“…Rods and cones are equally affected; as a consequence, flattening of the alpha wave in electroretinogram (ERG) is observed. 2,3 After the first description of recoverin, many other autoantigens that generate a clinical presentation similar to recoverin were discovered. 1,2,4 According to some authors, different molecules transmitted via different pathways cause slightly different clinical symptoms.…”

Section: Cancer-associated Retinopathymentioning

confidence: 99%

“…10 Turaka et al described a case of CAR with positive antiretinal autoantibodies against 48-kDa (arrestin), 64-kDa and 94-kDa, probably in the course of ovarian mass, in 14-year-old girl of African origin. 3 Common clinical manifestations of the first ophthalmological symptoms include both cone dysfunction (photosensitivity, prolonged glare, decreased best-corrected visual acuity -BCVA, color discrimination, and central scotomas) and rode dysfunction (night blindness, prolonged adaptation to darkness and peripheral or ring scotomas). Other clinical symptoms have been described as arteriolar narrowing, retinal pigment epithelial thinning and motting, vitritis, cells in anterior chamber, sheathing of retinal arterioles, periphlebitis, and pallor of the optic disc.…”

Section: Cancer-associated Retinopathymentioning

confidence: 99%

“…Neoplasms causing CAR can be as follows: smallcell carcinoma of the lung, other neoplasm of the lung, breast cancer, osteosarcoma, cancers of the cervix, ovary, uterus and thymus, Warthin tumor of parotid gland, as well as carcinoma of unknown origin. [1][2][3][5][6][7]11,12 There are single reports of patients with prostate, pancreatic neurocrine and small intestine tumors. 14,15 In the past CAR has been reported in bladder and laryngeal neoplasms as well as in lymphomas (systemic follicular cell lymphoma) or colon adenoma -only as case reports or case series.…”

Section: Cancer-associated Retinopathymentioning

confidence: 99%

See 1 more Smart Citation

Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings

Kordyś¹,

Przeździecka-Dołyk²,

Turno-Kręcicka³

et al. 2018

Adv Clin Exp Med

View full text Add to dashboard Cite

The aim of this study was to summarize the current knowledge of paraneoplastic syndromes involving eyes. The main interest was the immunopathogenesis of the abovementioned entities. A web search was conducted using Medline, Web of Science and Scopus engines. Key words concerning ocular paraneoplastic syndromes (OPS) such as: "ocular paraneoplastic syndrome", "cancer-associated retinopathy", "cancer-associated cone dysfunction", "melanoma-associated retinopathy", "bilateral diffuse uveal melanocytic proliferation", and "paraneoplastic optic neuritis" were combined with "immunology", "immune response", "antibodies", or "autoantibodies". Numerous papers were found as a result of "ocular paraneoplastic syndrome" search and many of them matched the chosen criteria. We focused on the most recent papers -published in the last 5 years -and eventually, 92 items were found. Only several papers from each detailed category fulfilled both OPS and immunologic criteria. Site-specific paraneoplastic syndromes still remain a difficult clinical challenge. The immunopathogenesis of some of them seems to be more complex than previously thought.

show abstract

Carcinoma-associated retinopathy in a young teenager with immature teratoma of the ovary

Cited by 17 publications

References 5 publications

Choroidal mass secondary to mucinous cystadenocarcinoma of ovary in a young woman: a life-threatening metastasis

Choroidal mass secondary to mucinous cystadenocarcinoma of ovary in a young woman: a life-threatening metastasis

Correlation of Immunological Markers with Disease and Clinical Outcome Measures in Patients with Autoimmune Retinopathy

Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings

Contact Info

Product

Resources

About