Carcinoma arising in epidermoid cyst: a case series and aetiological investigation of human papillomavirus

Morgan, M.B.; Stevens, G.L.; Somach, Stephen C.; Tannenbaum, Myron

doi:10.1111/j.1365-2133.2001.04400.x

Cited by 6 publications

(13 citation statements)

References 7 publications

(6 reference statements)

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“…It has been postulated that chronic irritation could exacerbate dysplasia in a way similar to field effect, predisposing to malignancy. Morgan et al investigated whether human papilloma virus (HPV) could contribute to malignant transformation of benign lesions, but unfortunately they were unable to demonstrate the presence of the virus in the lesions . In the present case it is interesting to speculate as to the likely trigger for malignant transformation.…”

Section: Discussionmentioning

confidence: 70%

“…On review of the English‐language literature, we identified 21 well‐documented cases of squamous cell carcinoma arising from epidermal cyst after excluding cases lacking conclusive histological evidence of epidermal cyst, and those in which the histological description was more in favor of pilonidal cyst . Table summarizes the clinical data available from reported cases.…”

Section: Discussionmentioning

confidence: 99%

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Squamous cell carcinoma arising from a vulval epidermal cyst

Sze

Richmond

Bickers

et al. 2016

J of Obstet and Gynaecol

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Malignant transformation of epidermal cyst is rare, with most cases arising in the head and neck. Here, we report a case of squamous cell carcinoma arising from a longstanding epidermal cyst in the right vulva of a 65-year-old woman. The patient presented with a sudden increase in size of the cyst over 6 weeks to the size of a golf ball. Excisional biopsy and histology indicated moderately differentiated squamous cell carcinoma within an epidermal cyst (FIGO stage IB). Strong p16 immunopositivity was also demonstrated and the potential significance of this is discussed. Limited right hemivulvectomy and right groin node dissection were performed.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma arising from a vulval epidermal cyst

Sze

Richmond

Bickers

et al. 2016

J of Obstet and Gynaecol

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“…In a review of the English-language literature, we found 25 cases of SCC arising in an EIC. cases, 14 occurred in the head and neck area, [1][2][3]9,11 four in the buttock region, 1,4,7,10 five in the trunk and extremities, 1,2,5,6 one in perineum, 11 and only one occured in the perirectal region. 12 Many of these were cured with complete excision.…”

Section: Discussionmentioning

confidence: 96%

“…There have been 25 cases reported in the English-language literature since 1976, one in the pericoccygeal region. [1][2][3][4][5][6][7][8][9][10][11][12] Of 25 cases, 14 occurred in the head and neck area, [1][2][3]9,11 four in the buttock region, 1,4,7,10 five in the trunk and extremities, 1,2,5,6 one in perineum, 11 and only one occured in the perirectal region. 12 SCC in these cysts has been reported in up to 0.045% of cases.…”

Section: Introductionmentioning

confidence: 99%

<p>Squamous-cell carcinoma arising in a pericoccygeal–rectal epithelial inclusion cyst with adjacent benign notochordal cell tumor: first case report and review of the literature</p>

López¹,

Schoeniger²,

Zhou³

2019

PLMI

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Background: Malignant transformation of epidermal inclusion cysts (EICs) is rare. Only one case has been reported in the pericoccygeal-rectal region. Benign notochordal cell tumor (BNCT) is also rare. There have been no reports of squamous-cell carcinoma (SCC) arising in EICs with adjacent BNCT in the English-language literature. Case presentation: An 83-year-old male patient with a history of malignant fibrous histiocytoma of the thigh after resection and irradiation presented clinically with a pericoccygealrectal, flocculent, painful mass 7 cm in diameter. No osseous destruction was associated on magnetic resonance imaging. Partial sacrectomy and coccygectomy with en bloc resection of retrorectal cystic tumor were performed. Histology showed SCC arising from an EIC. SCC cells were positive for p53, EGFR, p16, and cytokeratin 5/6 on immunostaining and negative for human papillomavirus. Adjacent to the EIC, one tumor showed bland cells with numerous intracytoplasmic vacuoles. These cells were positive for epithelial membrane antigen, pancytokeratin, S100, and negative for CD68, which confirmed the diagnosis of BNCT. The diagnosis was well moderately differentiated invasive SCC arising in an EIC with an adjacent BNCT abutting to bone. Conclusion: We report the first case of SCC arising from an EIC with an adjacent BNCT in a patient with a history of malignant fibrous histiocytoma. Partial sacrectomy and coccygectomy with en bloc resection of retrorectal cystic tumor and wide margins taken prevented recurrence of both tumors.

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“…Eine Superinfektion oder eine Fistelung lag in keinem der in der Literatur beschriebenen Fälle vor. Auch Morgan und Kollegen berichten über 5 Fälle, bei denen eine sekundäre maligne Entartung auf Grundlage einer Epidermoidzyste entstanden ist [8]. Die Autoren vermuteten einen Zusammenhang einer HPV-Infektion mit der malignen Entartung der Zyste, welche sich aber in keinem der 5 Fälle nachweisen ließ.…”

Section: Laborunclassified

Superinfektion einer epidermalen Inklusionszyste des Oberschenkels mit Ausbildung eines Plattenepithelkarzinoms – Fallbericht einer seltenen Komplikation

Zajonz¹,

Höh²,

Tiemann

et al. 2014

Z Orthop Unfall

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Epidermal cysts (atheroma) are the most common benign tumours of the skin with ubiquitous localisation all over the body. However, rupture of the atheroma and formation of an inclusion cyst with additional superinfections are frequently seen. Malignant transformations have rarely been reported. Presented here is the unusual case of a 65-year-old woman with multiple atheromas and a distinctive tumour of the upper limb. Imaging diagnostics showed malignant deformation. Contrary to the imaging findings the histological/microbiological examination showed an enormous superinfected and ruptured epidermoid cyst with multiple abscess formation in the ventral upper limb. Radical surgical restoration with salvage of the limb was frustrated because of honey-combed anterior soft tissue and the changing bacterial spectrum. After resection of the complete ventral compartment, remission was realised approximately. In the follow-up there was a recurring infection with spontaneous fistula formation that histologically impressed as a squamous cell carcinoma. After proximal ablation of the upper limb, total rehabilitation of the infection as well as the malignoma could be achieved.

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Carcinoma arising in epidermoid cyst: a case series and aetiological investigation of human papillomavirus

Cited by 6 publications

References 7 publications

Squamous cell carcinoma arising from a vulval epidermal cyst

Squamous cell carcinoma arising from a vulval epidermal cyst

<p>Squamous-cell carcinoma arising in a pericoccygeal–rectal epithelial inclusion cyst with adjacent benign notochordal cell tumor: first case report and review of the literature</p>

Superinfektion einer epidermalen Inklusionszyste des Oberschenkels mit Ausbildung eines Plattenepithelkarzinoms – Fallbericht einer seltenen Komplikation

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