Carcinoma and Ulcerative Colitis a Clinical-Pathologic Study

Radiological findings in carcinoma of the colon complicating chronic ulcerative colitis.

“…The likelihood of developing a new primary carcinoma following a partial resection of bowel, 370% in our series, also has been noted by others (Farmer and Brown, 1964;MacDougall, 1964;Slaney and Brooke, 1959). This experience warrants reaffirmation of the need for a total colectomy once a carcinoma has been detected in the colon of these patients (Goldgraber and Kirsner, 1964;Shands et al 1952). Rosenqvist et al (1959), however, noted only two of 26 carcinomas in the rectum and feel justified in preserving that portion of the bowel.…”

“…The multiplicity of the tumours arising in these patients also is noteworthy (Goldgraber, Humphreys, Kirsner, and Palmer, 1958;Hodgson and Sauer, 1961;Goldgraber and Kirsner, 1964;Diaz et al, 1965;Fennessy et al, 1966;Hinton, 1966). Two or more primary carcinomas arose in 340%.…”

“…In spite of this generally poor prognosis, occasional patients survive for long periods, despite the finding of lymph node metastases at the time of surgery (Goldgraber and Kirsner, 1964) (Fig. 2).…”

“…In some cases, however, carcinoma was strongly suspected because of the onset of pain or obstructive symptoms. Occasionally, a diagnosis of carcinoma was made or confirmed by colon cytology (Goldgraber, Humphreys, Kirsner, and Palmer, 1958;Goldgraber and Kirsner, 1964). The patients usually presented with an exacerbation or recurrence of the symptoms of ulcerative colitis.…”

Detection of Human Papillomavirus Type 16 in Squamous Cell Carcinoma of the Colon and Its Lymph Node Metastases with PCR and Southern Blot Hybridization

“…(b) Development from on the base of on chronic inflammations, e.g. ulcerative colitis [17][18][19] from undifferentiated cells due to irritation or injuries of the mucous membrane. (c) From chronic infections, e.g.…”