Carcinoid tumour of the oesophagus: a systematic review

Abstract

IntroductionKnowledge about oesophageal carcinoids is based primarily on case reports, and therefore information about them is incomplete.AimTo collect information on oesophageal carcinoid tumours in a systematic review study.Material and methodsDatabases including PubMed, Scopus, and Web of Science were searched for the characteristics of oesophageal carcinoid tumour. Studies included original articles, case series, or case reports, reporting at least one of the characteristics of benign carcinoid tumour or carcinoid tumour.ResultsOut of 670 studies searched, after evaluation and excluding non-relevant studies, 14 studies were included and analysed in the systematic review. These studies included 19 patients with carcinoid tumour of whom 57.9% were males with a mean age of 55.5 years. Dysphagia and weight loss were the most prevalent symptoms and signs in the patients. Lower oesophagus was the most prevalent site of tumour.ConclusionsThis meta-analysis showed that the mean age at diagnosis of oesophageal carcinoid was around 55 years, with 1.4 times greater prevalence among males, and located mainly in the distal oesophagus. The mean tumour size was 2.4 cm. The main symptoms and signs of this disease were dysphagia, weight loss, and reflux. The tumour behaviour was mainly non-aggressive except for cases associated with adenocarcinoma.

A Case Report of Rare Synchronous Esophageal Malignancies With Dissimilar Histology: Squamous Cell Carcinoma and Small Cell Carcinoma

“…Furthermore, most neuroendocrine tumors, particularly carcinoid tumors, in the esophagus are located at the middle or lower end of the esophagus. They are not aggressive unless associated with features of adenocarcinoma in the same lesion [ 16 , 17 ]. Our patient’s small cell carcinoma was located in the upper third of the esophagus, an uncommon site.…”