Carcinoid tumour of the appendix

Goede, A. C.; Caplin, Martyn; Winslet, M. C.

doi:10.1002/bjs.4375

Cited by 210 publications

(200 citation statements)

References 28 publications

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“…This series also confirms that appendix carcinoid patients have a high risk for synchronous and metachronous colorectal adenocarcinoma. Appendix carcinoids are relatively rare entities, reported in <1% of appendectomies [6,8]; our rate was slightly higher (1.2%). Appendectomy is one of the most common abdominal operations [7,9].…”

Section: Discussioncontrasting

confidence: 55%

“…Appendix carcinoids are relatively indolent neoplasms, rarely associated with carcinoid syndrome [16,20], that are usually discovered in association with acute appendicitis [3,8], as was the case in 64% of our patients. Diagnosis is usually done either during operation or mainly during pathological examination of the resected appendix [2,8], which is corroborated by our results.…”

Section: Discussionmentioning

confidence: 57%

“…Patients treated for appendix carcinoid have an increased risk of second cancer [2,8,15,20,21], which was the case in 18% of our patients. The increased risk of second cancer in patients with carcinoid may be related to a genetic predisposition to certain cancer, including neuroendocrine and nonneuroendocrine tumors [21].…”

Section: Discussionmentioning

confidence: 64%

“…Two cases of surgical margin invasion were encountered after laparoscopic resection, whereas there was only one such adverse event after open resection, all in patients with carcinoid >2 cm. Finally, the need for subsequent right colectomy, in accordance with international guideline [8,10,13], was indicated with similar frequencies after both laparoscopic and open appendectomy. Although our data suggest that the prognosis of patients treated for appendix carcinoid is similar after laparoscopic and open appendectomy, diagnostic confirmation is seldom available before pathological examination of the specimen.…”

Section: Discussionmentioning

confidence: 99%

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Laparoscopic versus open resection for appendix carcinoid

et al. 2006

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Background: Since an increasing number of appendectomies are performed via laparoscopy, it is crucial to determine the impact of this approach on appendix carcinoid (AC) outcome. The goal of this study was to compare results of laparoscopic (LAP) versus open (OP) appendectomy for AC according to intend to treat approach. Methods: A retrospective review (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003) identified 39 patients (median age, 36 years; range, 12-83) treated by laparoscopy (LAP) or laparotomy (OP) for AC in a single institution. Follow-up was complete for all patients (median, 67 months; range, 4-132). Results: Most cases had associated acute appendicitis (64%). Median carcinoid size was 1.1 cm (range, 0.3-5) and 0.4 cm (range, 0.2-3) in the LAP and OP groups, respectively. LAP and OP were performed in 21 (54%) and 18 (46%) patients, respectively. Surgical margins were positive in two patients in the LAP group and one patient in the OP group (p = 0.6). Right colectomies were performed for AC >2 cm in five patients after LAP and in four patients after OP (p = 0.9). Actuarial 5-year survival rates were 100 and 94% in the LAP and OP groups, respectively (p = 0.2). Two patients died in the OP group, one due to metastatic carcinoid and the other due to metachronous colorectal cancer. Synchronous or metachronous colorectal carcinomas developed in six patients (15%). Conclusion: Laparoscopic appendectomy is a safe procedure for AC, with carcinologic and long-term results similar to those of conventional appendectomy. Thus, pre-or per-operative suspicion of AC is not a contraindication to LAP. Prognosis of AC appears more dependent on carcinoid malignant potential or associated tumors. Risk for developing colorectal adenocarcinoma is high in AC patients and warrants follow-up of all patients with colonoscopic screening.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Laparoscopic versus open resection for appendix carcinoid

et al. 2006

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“…Tümör davranışını belirlemede tümör büyüklüğü, lenf nodu varlığı, histolojik alttipi, tümör pozitif cerrahi sınır, yüksek mitotik indeksle sellüler pleomorfizm ve mezoapendiks yayılımı önemlidir. [9][10][11] Mitotik indeks 10 büyük büyütmede genellikle %1'den daha az görülmektedir. Eğer 10 büyük büyütmede iki veya üç bulunursa prognoz oldukça kötüdür.…”

Section: Discussionunclassified

Carcinoid tumor of the appendix detected incidentally

Başak¹,

Hasbahçeci²,

Canbak³

et al. 2014

J Kartal TR

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Is Right Hemicolectomy for 2.0-cm Appendiceal Carcinoids Justified?

Bamboat

Berger²

2006

Arch Surg

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We believe right hemicolectomy (RHC) is not necessary in patients with an appendiceal carcinoid greater than 2.0 cm. Design: A retrospective review of patients with a histologically confirmed appendiceal carcinoid from April 1, 1980, to February 28, 2005, and an analysis of the literature. Setting: Tertiary care referral center. Patients: Forty-eight patients (34 females and 14 males) with a histologically confirmed diagnosis of appendiceal carcinoid were included in the study. Appendiceal carcinoid was diagnosed incidentally in all 48 patients. Patient ages ranged from 11 to 86 years (mean age, 41 years). Postoperative follow-up and disease-free survival were confirmed in 33 patients via medical record review. Main Outcome Measures: We assessed the relationship between survival, tumor size, and the role of RHC vs appendectomy alone. Results: Four patients in our series underwent secondary RHC and lymph node dissection for tumors greater than 2.0 cm, and none had positive lymph nodes. Following review of the literature, we were unable to find any recent evidence ofdistantmetastasisfromcarcinoidsinpatientsalreadytreated by appendectomy. There seem to be no conclusive data to support the notion that RHC confers a survival benefit over appendectomy for carcinoids greater than 2.0 cm. Conclusion: Appendiceal carcinoids greater than 2.0 cm can be managed effectively with simple appendectomy, given their low malignant potential and slow growth, obviating the need for RHC in this group of patients without affecting overall survival.

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Carcinoid tumour of the appendix

Cited by 210 publications

References 28 publications

Laparoscopic versus open resection for appendix carcinoid

Laparoscopic versus open resection for appendix carcinoid

Carcinoid tumor of the appendix detected incidentally

Is Right Hemicolectomy for 2.0-cm Appendiceal Carcinoids Justified?

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