Carcinoid Tumors (So-Called) of the Ileum

Dockerty, Malcolm B.

doi:10.1001/archsurg.1943.01220150002001

Cited by 53 publications

(11 citation statements)

References 17 publications

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“…These considerations make it plausible to suggest that more than one cell type can give rise to carcinoids, some of which might in turn have the potential to develop into mucinous tumour cells. Embryologically, the common origin of basiglandular cells and mature goblet cells from the primitive entoderm (Azzopardi and Pollack, 1963;Clara, 1934;Dockerty and Ashburn, 1943;Gibbs, 1963;Masson, 1928 and1930;Stohr, Mollendorff and Goerttler, 1959) is consistent with this view.…”

Section: Discussionmentioning

confidence: 58%

“…The literature on gastrointestinal carcinoids is replete with examples depicting the existence of mucin-secreting adenocarcinomatous areas (Bates and Belter, 1967;Black and Haffner, 1968;Cordier, 1924;Dockerty and Ashburn, 1943;Gibbs, 1963;Hernandez and Reid, 1969;Horn, 1949;Lattes and Grossi, 1956;Pearson and Fitzgerald, 1949;Siburg, 1929;Stout, 1942;Toker, 1969). Adenocarcinomas of the alimentary tract have also been described which contain a few argentaffin cells (Azzopardi and Pollack, 1963;Gibbs, 1967;Hamperl, 1927;Lillie and Glenner, 1960;Masson and Martin, 1928).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, there has been a renewed interest in the histogenesis of carcinoids of the gastrointestinal tract and their relationship to adenocarcinoma of this site. Morphologically, the coexistence of areas of carcinoid and adenocarcinoma within some malignant gastrointestinal neoplasms is a well documented event (Bates and Belter, 1967;Gibbs, 1963;Hernandez and Reid, 1969;Toker, 1969) and continues to provoke the view suggesting a histogenetic relationship between these two tumour cell types (Dockerty and Ashburn, 1943;Gibbs, 1963Gibbs, , 1967Toker, 1969). Hernandez and Reid (1969) present histological evidence indicating a transition between the cells of carcinoids and mucin-secreting adenocarcinomas.…”

Section: Yearsmentioning

confidence: 99%

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Histogenetic Relationship Between Carcinoids and Mucin-secreting Carcinomas of Colon as Revealed by Heterotransplantation

Goldenberg¹,

Fisher²

1970

Br J Cancer

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Heterotransplantation of a human colonic neoplasm with classical morphologic characteristics of a carcinoid was sucessful in the cheek pouches of unconditioned, adult golden hamsters after a short sojourn in cell-impermeable chambers in rats. Although no mucin-secreting cells were detected in the donor carcinoid, the cheek pouch transplants exclusively exhibited mucinsecreting tumour cells of signet-ring type consistent with adenocarcinoma. This transplantable tumour, designated GW-77, has retained this appearance as well as expansive growth characteristics in xenogeneic hosts for a period of 4 years. These findings represent strong biological evidence consonant with views, based upon morphological findings, advocating a histogenetic relationship between colonic carcinoid and adenocarcinoma. It is believed that colonic adenocarcinoma has a selective advantage over carcinoid for serial propagation in an alien environment, indicating the less differentiated nature of its cellular components. Since the donor carcinoid cells failed to exhibit argentaffin reactions, these conclusions may be limited only to the nonreactive forms of carcinoid. Images Figs. 1-2 Figs. 3-4

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Yearsmentioning

confidence: 99%

See 1 more Smart Citation

Histogenetic Relationship Between Carcinoids and Mucin-secreting Carcinomas of Colon as Revealed by Heterotransplantation

Goldenberg¹,

Fisher²

1970

Br J Cancer

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“…Although jt is conceivable that the thecoma originated in the pluripotential tissue of the teratoma, it is reasonable to argue that the combination in the present instance is fortuitous. A well-recognized association with a dermoid cyst is that of pseudo-mucinous cystadenoma, which is an integral part of 10 per cent of cystic teratomas (Dockerty, 1945). Coincident solid mesenchymal tumours have also been described : Dockerty and Masson (1944) found a fibroma combined with a dermoid cyst, and Dockerty (1945) mentions an instance of a Brenner tumour in the tissues of a teratoma.…”

Section: Discussionmentioning

confidence: 99%

Combined Thecoma and Teratoma

Lewis

Percival

1965

BJOG

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“…Spies emphasized that the tumour was a distinct entity and should not be confused with the adenoid cystic epithelioma of Brooks and Fordyce, and that it was different from adenocarcinoma. Adenocarcinoma of mixed tumour type has also been used as a designation (New andChildrey, 1931 Watson, 1935), and adenocarcinoma of cylindroma type (Dockerty andMayo, 1942, 1943;Quattelbaum, Dockery and Mayo, 1946). The original term cylindroma has come back into faTour recently, and Lennox (1960) comments "I can find no better name than ' cylindroma ' for the group, though few members contain any cylindrical structures".…”

Section: Nomenclaturementioning

confidence: 99%

The Histology of Cylindroma of Mucous Gland Origin

Thackray¹,

Lucas²

1960

Br J Cancer

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IT is now generally agreed that classification of mucous gland tumours on histological grounds is a useful procedure since the various types of tumour bear differing prognoses. Though there is still lack of unanimity with regard to details of nomenclature, most pathologists and clinicians would probably agree to the recognition of the following neoplasms as distinct entities.1. Mixed tumours.-These are the neoplasms traditionally described These four groups of neoplasms constitute the great majority of all tumours of mucous glands and warrant separate recognition on grounds of structure and behaviour. In addition, there are the less common tumours such as those of the oxyphil, acinic cell and papillary cystadenoma type, and the mesenchymal tumours, which are not further considered here.With regard to the behaviour of the commoner neoplasms, the mixed tumours are generally regarded as benign. However, they show a marked propensity for recurrence, due to factors such as the leaving behind of peripheral nodules of growth after enucleation, the implantation of neoplastic cells in the tumour bed and the presence of focal infiltrations (Patey and Thackray, 1958). Apart from recurrences due to such causes there is the question of whether mixed tumours can change in type to become carcinomatous. It is generally believed that such changes do occur in a certain proportion of cases (Foote and Frazell, 1953;Frazell, 1954;Patey and Thackray, 1958) but that on the whole they are infrequent.The muco-epidermoid tumours, on the other hand, behave as malignant growths, both with regard to local invasion and metastatic deposits. The cylindromas show a similar natural history, for they too are locally invasive growths and are also capable of giving rise to metastases. Their rate of growth, however,

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Carcinoid Tumors (So-Called) of the Ileum

Cited by 53 publications

References 17 publications

Histogenetic Relationship Between Carcinoids and Mucin-secreting Carcinomas of Colon as Revealed by Heterotransplantation

Histogenetic Relationship Between Carcinoids and Mucin-secreting Carcinomas of Colon as Revealed by Heterotransplantation

Combined Thecoma and Teratoma

The Histology of Cylindroma of Mucous Gland Origin

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