Carcinoid tumors of the lung and family history of cancer

Perkins, Penny; Lee, Ju Ruey Jiuan; Kemp, Bonnie L.; Cox, James D.

doi:10.1016/s0895-4356(97)00016-4

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…MEN1 is the first well-characterized genetic alteration of these tumors (72). The MEN1 gene in pulmonary tumors indicates a possible familial component to these cancers (84). Also, LOH at chromosome 3p14.2-p21.3 is significantly more extensive in atypical carcinoid tumors (85,86).…”

Section: Men1mentioning

confidence: 99%

Carcinoid A Comprehensive Review

2003

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Carcinoid tumors originate from the neuroendocrine cells throughout the body and are capable of producing various peptides. Their clinical course is often indolent but can also be aggressive and resistant to therapy. We examined all aspects of carcinoid tumors including the molecular biology oncogenesis, role of angiogenesis, recent advances in imaging, and therapy. The Medline and Cancerlit databases were searched using carcinoid as the keyword. English language manuscripts were reviewed and relevant references from a total of 7741 were found. All titles were screened and all the relevant manuscripts were analyzed; we found 307 references pertinent to the history, epidemiology, clinical behavior, pathology, pathophysiology, molecular biology, radiologic imaging, supportive care of carcinoid syndrome, and results of therapeutic clinical trials. Management of patients with carcinoid tumors requires an understanding of the disease process and a multimodality approach. Introduction of long-acting somatostatin analogues has resulted in significant advances in the palliative care of patients with carcinoid syndrome. However, advanced carcinoid tumor remains incurable. Existing therapies for advanced disease have low biologic activity, high toxicity, or both. Clearly, more research is necessary in the areas of molecular biology, targeted therapy, and development of new drugs Future advances in this field need to focus on clinical and biological predictors of outcome. Early works in the area of tumor biology such as the role of p53, bcl-2, bax, MEN1, FGF TGF PDGF and VEGF expression are of interest and need to be explored further.

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Section: Men1mentioning

confidence: 99%

Carcinoid A Comprehensive Review

2003

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Family health effects: complements or substitutes

Ganz

2001

Health Economics

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Genetic endowments play a fundamental role in the production of health. At birth individuals have different capacities to be healthy, largely due to genetic dispositions. Whether or not individuals realize this health depends on their choice of health behaviours. Previous research has linked negative factors beyond the individual's control, which include genetic endowments, to both poor health and poor health behaviours. The health economics literature proposes that behaviours and genetic (or family health) endowments can be either substitutes or complements in the production of health. The goal of this paper is to investigate the behavioural consequences of changes in knowledge about one's genetic endowment. Using two waves of the National Health and Nutrition Examination Survey I Epidemiologic Followup Study, I find that for smokers, smoking intensity substitutes for newly diagnosed smoking-related family cancers, while smoking intensity is complementary to newly diagnosed non-smoking-related family cancers. I find no evidence for the hypothesized relationships with respect to alcohol consumption among drinkers. These results have implications for the growing field of genetic testing and test development. These results also reinforce current practices of ascertaining family health histories in the context of medical history taking.

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Heterogeneity of So-Called Neuroendocrine Lung Tumors

Yesner

2001

Experimental and Molecular Pathology

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Carcinoid tumors of the lung and family history of cancer

Cited by 6 publications

References 25 publications

Carcinoid A Comprehensive Review

Carcinoid A Comprehensive Review

Family health effects: complements or substitutes

Heterogeneity of So-Called Neuroendocrine Lung Tumors

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