Carcinoid tumor of the thymus with multiple endocrine adenomatosis

Floros, D.; Dosios, T.; Tsourdis, A.; Yiatromanolakis, N.

doi:10.1016/s0344-0338(82)80053-8

Cited by 22 publications

(4 citation statements)

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“…According to previous reports, a male predominance and an association with Cushing's syndrome (20-35%) were found in patients with thymic carcinoid, although we found that the presence of Cushing's syndrome was not related to the tumour size or the extent of the disease. Thymic carcinoid tumours associated with a multiple endocrine neoplasia syndrome are rare.67 [12][13][14] In this study three of eight cases had a previous history of thyroid cancer. The association of carcinoid tumour with medullary carcinoma of the thyroid has been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid tumours of the thymus.

Wang

Chang

Kuo

et al. 1994

Thorax

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Section: Discussionmentioning

confidence: 99%

Carcinoid tumours of the thymus.

Wang

Chang

Kuo

et al. 1994

Thorax

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“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] The majority of these patients were men (93%), with an average age of 43 years. Among the 43 patients whose MEN1 features were described, hyperparathyroidism was diagnosed in 40 (93%), an endocrine pancreatic tumor in 16 (37%), prolactinoma in 7 (16%), an adrenocortical tumor in 6 (14%), lipoma in 4 (9%), and a thyroid nodule in 2 (5%).…”

Section: Discussionmentioning

confidence: 99%

Thymic Carcinoid in a Patient with Multiple Endocrine Neoplasia Type 1: Report of a Case

et al. 2001

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We report herein the rare case of a 33-year-old man found to have a multiple endocrine neoplasia type 1 (MEN1)-associated carcinoid tumor in the thymus. A chest roentgenogram demonstrated an asymptomatic anterior mediastinal mass, 7 cm in diameter, and ultrasound-guided percutaneous Tru-Cut biopsy revealed a carcinoid tumor of the thymus. An extended thymectomy was performed through a median sternotomy and pathological examination confirmed the diagnosis of a thymic carcinoid tumor, which was mainly encapsulated with locally invasive growth into the pleura. Despite the absence of a family history of MEN1, he was treated for two pancreatic islet cell tumors, hyperparathyroidism, an adrenal tumor, and a retroperitoneal lipoma. MEN1 mutations were detected both in blood samples and pancreatic tumor tissues. He is now well without any evidence of tumor recurrence 27 months after the operation for the thymic carcinoid. MEN1 mutations were screened by direct nucleotide sequencing of all protein-coding regions of exons 2-10 of the MEN1 gene. Heterozygous germline mutation was detected in the blood sample analyses. Moreover, fresh-frozen pancreatic tumor tissues showed a loss of heterozygosity in the MEN1 region.

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“…Patients may be asymptomatic or present with signs and symptoms related to a rapidly growing tumor. About one third of patients present with endocrine symptoms, particularly MEN type I syndrome, 183 and other conditions such as polyarthropathy, proximal myopathy, peripheral neuropathy, hyperparathyroidism, inappropriate antidiuretic hormone secretion, Eaton-Lambert syndrome, and hypertrophic osteoarthropathy. Thymic neuroendocrine carcinomas are not associated with myasthenia gravis, hypogammaglobulinemia, or carcinoid syndrome.…”

Section: Neuroendocrine Carcinomas Of the Thymusmentioning

confidence: 99%