Carcinoid tumor of the gallbladder: report of two cases

Abstract

We report two cases of carcinoid tumor of the gallbladder. Case 1 was a 59-year-old woman who presented with epigastric pain. Abdominal ultrasonography and computed tomography (CT) revealed a 16 mm polypoid lesion in the neck of the gallbladder. Tumor markers were within normal limits. Open cholecystectomy was performed with a preoperative diagnosis of early cancer of the gallbladder. Case 2 was a 45-year-old man. A polyp in the gallbladder was incidentally detected on annual checkup. Ultrasound and CT showed an 18 mm protruding lesion in the neck of the gallbladder. Laparoscopic cholecystectomy was performed and the tumor diagnosed as a carcinoid tumor based on the findings of funicular and tubular cells in the lamina propria mucosa, homogeneous nuclei, basophilic cytoplasm, and positive staining with chromogranin A and synaptophysin. The postoperative course of both patients was uneventful, with no recurrence at 44 and 41 months after surgery. In this literature review of 39 cases, classical carcinoid of the gallbladder has a favorable postoperative outcome. Of cases reviewed, 60% are located in the neck of the gallbladder and 50% have a polypoid shape.

Gallbladder primary well-differentiated neuroendocrine tumor: A misdiagnosed case

“…So that, the preoperative diagnosis of GB-NETs and GB-NENs generally is difficult because there are no specific symptoms, and the radiological results are no different from those of other gallbladder tumors [ 14 ]. A benign polyp could be the mode of discovery of NEN in 31.6 % of cases [ 15 , 16 ]. That is why, GB-NEN are often incidentally detected by routine histopathological examination of cholecystectomy specimen [ 14 ].…”

A Case of a Grade 3 Gallbladder Neuroendocrine Tumor With Rapid Recurrence After Curative Resection

“…The World Health Organization (WHO) proposed a new category in 2019, wherein GBneuroendocrine neoplasms (GB-NENs) are divided into three categories, namely: NET (grade 1, 2, or 3 NETs), neuroendocrine carcinomas (NECs, large cell or small cell type), and mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) [3]. However, such tumor behaviors and adequate treatment for this condition are still relatively unknown because this tumor is extremely rare [4,5].…”

Gallbladder Adenoumatous Polyps prevelance in Cholcystectomy in Saudi Arabia-cross sectional study

“…Association with stroke have been reported, but need more studies to explore this fi nding [9]. Some reports of GP being a metastasis from other organs, like renal cell carcinoma [10], or with lymphoma of gallbladder [11], carcinoid tumor [12,13]. Adenomatous polyps fi rst described in literature by da costa et al 1961 [14].…”