Carcinoid of the pancreas

Nonductal neoplasms of the pancreas

“…9 Among the functional variants, 1 insulinomas make up 42%, gastrinomas 24%, glucagonomas 14%, VIPomas 10%, somatostatinomas 6%, and the remaining ectopic and multiple hormone-producing neoplasms are rare. [14][15][16] PENs are most common between the ages of 40 and 60 (mean ¼ 58) 4,17 and are rare in childhood. Overall, both men and women develop PENs with an equal frequency, although there are some differences in the male-to-female ratio among the different functional types.…”

“…85 Some cases have associated paraneoplastic syndromes including Cushing's syndrome, 86 hypercalcemia, 87 and carcinoid syndrome. 16 In contrast to well-differentiated PENs, poorly differentiated endocrine carcinomas are highly aggressive, with early dissemination and a rapidly fatal course. Some examples have the typical pathologic features of small cell carcinomas 85,88,89 and are designated as such.…”

Poorly Differentiated Carcinomas of the Foregut (Gastric, Duodenal and Pancreatic)

“…Presenting symptoms include jaundice, weight loss, abdominal pain and hepatomegaly. Symptoms due to hormone overproduction are rare, although cases with Cushing’s syndrome[ 18] and carcinoid syndrome[ 19] have been reported. Pancreatic PDECs are predominantly located in the pancreatic head, measure 4 cm in diameter and typically invade adjacent organs or metastasized at the time of diagnosis.…”

Pancreatic islet cell carcinoid: A highly malignant form of carcinoid tumor

“…Of these 7 cases, 3 were classed as adenocarcinomas, and 4 as islet cell tumors. On reviewing these 8 reports (Dollinger et al, 1967;Gordon et al, 1971) and including the present case, it was found that the survival from onset of symptoms until death ranged from 3 months to 4 years with a mean survival of 15 months.…”

“…A few lipid droplets were present in the cytoplasm of most cells. Gordon et al (1971) point out that despite the difference in diagnosis of pancreatic tumors producing the carcinoid syndrome, they have similar histologic features. That they arise from islets of Langerhans, and are a variant of an islet cell tumor, is often assumed from their histologic pattern.…”