Carcinoid of the Larynx

Nc, Goldman; Ci, Hood; Gt, Singleton

doi:10.1001/archotol.1969.00770030066013

Cited by 106 publications

(60 citation statements)

References 5 publications

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“…Subsequently, a considerable number of such cases have been reported as carcinoids, atypical carcinoids, malignant carcinoids, and neuroendocrine carcinomas (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In some of these earlier discussions, the cytologic and clinical features of the tumors were overtly malignant, yet the term carcinoid tumor was applied without further modification, emphasizing the nomenclature problem discussed above.…”

Section: Neuroendocrine Carcinomas and Related Neoplasms (Group 1)mentioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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Tumors exhibiting neuroectodermal differentiation occur throughout the body, and the diverse tissues of the head and neck give rise to a wide assortment of these neoplasms. Neuroectodermal neoplasms may be divided into lesions showing primarily epithelial differentiation (Group I, neuroendocrine carcinomas) and a more diverse group (Group II) of nonepithelial neoplasms. This article reviews these neuroectodermal tumors of the head and neck with emphasis on the neuroendocrine carcinomas and their nomenclature. The author believes that with regard to Group I tumors, the older terminology of carcinoid, atypical carcinoid, and small cell carcinoma should be replaced by subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma. The latter category should be further subdivided into small cell and large cell variants. Neuroendocrine carcinomas, particularly the moderately differentiated subtype, are often underdiagnosed in the head and neck region. In the larynx, these tumors are the most common form of nonsquamous carcinoma. Poorly differentiated neuroendocrine carcinoma of small cell type is most common in the salivary glands but can occur elsewhere in the region. The large cell subtype of poorly differentiated neuroendocrine carcinoma has not been well documented in this region. However, the most likely candidate for this tumor category is the so-called sinonasal undifferentiated carcinoma. Group II tumors discussed include olfactory neuroblastoma, malignant melanoma, and Ewing's sarcoma. In addition, differential diagnostic problems related to Group I and II tumors are reviewed in detail. This article reviews and updates our understanding of neuroectodermal neoplasms arising in the head and neck. The focus is on tumors that exclusively involve this region or show a strong predilection to occur here.

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Section: Neuroendocrine Carcinomas and Related Neoplasms (Group 1)mentioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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“…In 1955 Blanchard and Saunders reported the first neural type of laryngeal neuroendocrine carcinoma [5]. The first atypical laryngeal carcinoid was described by Goldmann et al in 1969 [6]. It is considered to be 3 times more common in males' average age being 50-70 yrs [7].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Neuroendocrine Tumour: A Rare Case Report and Review of Literature

Marfatia¹,

Priya²,

Sathe³

et al. 2016

SJMCR

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Neuroendocrine tumours consist of diverse group of neoplasms. They are the most common type of nonsquamous laryngeal malignancies (0.6-1%) and mainly affect males. Atypical carcinoid is the most common type and typical carcinoid being the rarest. A 60 year male patient presented to the ENT OPD with the chief compliant of irritation in the throat and foreign body sensation since past 6 months. He was a chronic smoker. On indirect laryngoscopy and 70 degree scopy there was a single well defined smooth globular mass over right arytenoid. Both the vocal cords were mobile. Rest of the larynx was normal and there was no pooling of saliva. Neck examination revealed no lymphadenopathy. Wide local excision was done and histopathology was suggestive of neuro endocrine tumour with immunohistochemistry suggestive of cells expressing chromogranin and synaptophysin diffusely and Ki67 was 10-12%. Tumour margins were free. Postoperative 70 degree scopy was absolutely normal with no residual lesion. The first atypical laryngeal carcinoid was described by Goldmann et al in 1969. They are characterised into neural (Paraganglioma) and epithelial types (atypical carcinoid, typical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma). Most common site of involvement in larynx is supraglottis. Clinical manifestations include dysphagia, hoarseness, odynophagia, dyspnoea and haemoptysis. The definitive diagnosis depends on histopathology according to the histological and immunohistochemistry features of the tumour type. The treatment of choice in atypical carcinoid is wide local excision or supraglottic laryngectomy ( as most tumours are supraglottic in location). Laryngeal neuroendocrine tumours of the larynx are extremely uncommon. Multidisciplinary approach is required to treat the tumours efficiently.

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“…A review of 2,837 examples of carci noid tumours on the files of the American National Cancer Institute revealed no carci noid tumour of the larynx [52]. The first case was reported by Goldman et al [1], followed by Horikawa and Matsubara [10], Ferlito [2] and others [3,4,[5][6][7][8][9], Macroscopically the neoplasm does not display any dis tinctive features and may be mistaken for a carcinoma. Its morphology is variable; often a mixed pattern predominates [53].…”

Section: Discussionmentioning

confidence: 99%

“…5, 6 The case mentioned by Ackerman and Rosai [30] is the same as the one reported by Goldman ct al. [ 1 ]. The case reported independently by Pages et al…”

Section: Histopathologymentioning

confidence: 93%

“…These special methods offer a reliable basis for the diagnosis of neuroendocrine neoplasms to which carcinoid tumours belong. The treatment of carcinoid neoplasms of the larynx is surgical.Carcinoid tumours of the larynx are rare neoplasms but their incidence is difficult to assess because such tumours have been mis diagnosed as undifferentiated carcinoma, squamous cell carcinoma, malignant mela noma, adenocarcinoma or metastatic renal cell carcinoma.This report is based on a review of carci noid tumours of the larynx published in the available literature and on the re-examina tion of five previously published cases [1][2][3][4] and a new case. Recent reviews on this sub ject seem to be incomplete.…”

mentioning

confidence: 99%

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Primary Carcinoid Tumour of the Larynx

Ferlito

Friedmann²,

Goldman³

1988

ORL

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Carcinoid neoplasms, although rare, have to be considered in the differential diagnosis of neoplasms of the larynx. The total number of cases reviewed and listed in the present article is 47. The gross appearance of carcinoid tumours is not characteristic and does not differ from that of other malignant neoplasms of the larynx. Under the light microscope various types can be distinguished, which are described and illustrated in this review article. Available material of five previously published cases and of one new case have been re-examined under the electron microscope and by modern histochemical and immunohistochemical methods. The ultrastructural presence of neurosecretory granules and of argyrophilia by the Grimelius technique were uniformly positive, together with monoclonal antibodies for somatostatin and keratin. These special methods offer a reliable basis for the diagnosis of neuroendocrine neoplasms to which carcinoid tumours belong. The treatment of carcinoid neoplasms of the larynx is surgical

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Carcinoid of the Larynx

Cited by 106 publications

References 5 publications

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

Laryngeal Neuroendocrine Tumour: A Rare Case Report and Review of Literature

Primary Carcinoid Tumour of the Larynx

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