Carcinoid of the cervix: Natural history and implications for therapy

R, Seidel; Steinfeld, Aldo

doi:10.1016/0090-8258(88)90053-4

Cited by 20 publications

(5 citation statements)

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“…Its clinicopathologic characteristics have suggested the potential role of adjuvant chemotherapy in the prevention of distant metastasis after local treatment for early stage disease, and regimens for small cell lung carcinoma have been advocated. Until July 1977, 46 cases of small cell cervical carcinoma treated with chemotherapy were reported in the English literature,2, 6, 10‐23 and 19 of those patients had received adjuvant chemotherapy after hysterectomy 2, 6, 10, 12, 13, 17‐24…”

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confidence: 99%

Prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy

Chang

Lai

Tseng

et al. 1998

Cancer

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BACKGROUND Small cell carcinoma of the uterine cervix is an uncommon tumor associated with high mortality even among patients with early stage disease. The role of adjuvant chemotherapy after surgery has been suggested by regimens used for small cell lung carcinoma. During the years 1980‐1997, 19 cases in which various adjuvant chemotherapies were given after hysterectomy were reported in the literature published in English. METHODS Adjuvant chemotherapy was administered consecutively to 23 patients with Stage Ib‐II small cell cervical carcinoma who had been primarily treated with radical hysterectomy and had adequate bone marrow, renal, and hepatic functions. A combination of vincristine, doxorubicin, and cyclophosphamide alternating with cisplatin and etoposide (VAC/PE) was administered to 14 patients during the years 1988‐1996 according to a prospective study protocol. A combination of cisplatin, vinblastine, and bleomycin (PVB) was administered to 8 patients, and another regimen was administered to 1 patient during the years 1984‐1988. Prognostic factors were evaluated by analyzing both the data on these 23 patients and the pooled data on the cases retrieved from the literature and our own files. RESULTS Ten of the 14 patients who received VAC/PE had no evidence of disease during a median follow‐up of 41 months, whereas 3 of the 9 who received PVB or another regimen survived. Of the 10 patients who died of their disease, all died of distant metastasis within 10 months after recurrence. Meta‐analysis of the pooled data showed that 68% of patients who received regimens containing VAC or PE survived, whereas 33% of patients who received regimens not containing VAC/PE survived (P = 0.0078, log rank test). Seventy percent of patients with no lymph node metastasis at hysterectomy and 35% with lymph node metastasis survived (P = 0.05). All patients who died of disease had extrapelvic metastasis. CONCLUSIONS Chemotherapies containing VAC or PE are favorable regimens for patients with early stage small cell cervical carcinoma after radical hysterectomy. Cancer 1998;83:712‐718. © 1998 American Cancer Society.

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confidence: 99%

Prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy

Chang

Lai

Tseng

et al. 1998

Cancer

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“…They rarely cause symptoms of`carcinoid syndrome' but frequently lead to disseminated disease (Seidel and Steinfeld, 1988). They have a wide histological spectrum, ranging from welldifferentiated types, similar to those of the gastrointestinal tract, to anaplastic types, similar to oat cell carcinoma of the bronchus.…”

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confidence: 99%

An unusual mixed tumour of the uterine cervix

Haughney

Reeve

Slade³

2000

Journal of Obstetrics and Gynaecology

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or persistence and abnormal anastomoses between the cardinal and supracardinal veins are responsible for the development of numerous morphological variants. Duplication of the IVC on the left side and absence of an internal iliac vein IVC have been described in the past. A short circuit to the IVC vians through the ovarian and femoral vein can be found in such cases (Mu È ller, 1971).This case is interesting because this type of malformation can be responsible for major complications and a modi® cation of the surgical approach. The operative risk associated with the venous anomaly can be avoided by preoperative radiological diagnosis, provided the malformation is suspected on clinical grounds.With the advent of abdominal CT, accurate visualisation of the retroperitoneum became possible and the three incidence of these venous anomalies could be appreciated. Also, the¯ow Doppler ultrasound has proved to be a useful diagnostic tool for on castigation of arteriovenous malformations (Hoffman et al., 1997). In this case, a concomitant hysterectomy would have been desirable for the staging of the tumour. However, it was not performed because of the potential risk of the venous malformation. Performing a hysterectomy in this situation would certainly have resulted in major haemostatic problems in the broad ligament and in the interruption of the major part of the venous return from the right leg. Such complications would undoubtedly have occurred in case of vaginal hysterectomy for presumed uterine benign disease because of the absence of preoperative diagnosis by CT abdominal scan.

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“…However, these tumors are generally aggressive in their behavior [38,39]. Like their prostatic counterparts, even the more differentiated carcinoid type tumors are commonly aggressive and fatal [40]. Chemotherapy as for small cell carcinomas of the lung, has also been recommended for cervical neuroendocrine carcinomas, and temporary remission has been achieved in some tumors, using this therapy [41].…”

Section: Apud Tumors In Reproductive Tissuesmentioning

confidence: 99%

Reproduction and the APUD system

Wanke¹

1993

Seminars in Surgical Oncology

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Substantial evidence for involvement of the APUD system in the normal reproductive tract is limited to the prostate gland and uterine cervix. Most supportive data simply documents the presence of neuro-endocrine cells in these tissues. A biological product(s) or role(s) remains to be discovered, but appears likely in the prostate. Tumors possessing cells with APUD characteristics have been described in many reproductive tissues including the prostate, cervix, endometrium, ovary, and testes. These tumors are generally aggressive in behavior, and optimum therapy needs to be determined.

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Carcinoid of the cervix: Natural history and implications for therapy

Cited by 20 publications

References 15 publications

Prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy

Prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy

An unusual mixed tumour of the uterine cervix

Reproduction and the APUD system

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