Carcinogens formed in the Heating of Foodstuffs. Formation of 3,4-Benzopyrene from Starch at 370-390° C

Davies, W.W.; Wilmshurst, JR

doi:10.1038/bjc.1960.34

Cited by 16 publications

(3 citation statements)

References 5 publications

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“…These results indicate that ethoxycoumarin dealkylase activity parallels BP hydroxylase activity in human placenta only in individuals with markedly induced BP hydroxylase activity. No detectable hydroxylation of coumarin in the 7-position was observed in placental homogenates from nonsmokers 0., from women who smoked cigarettes.Human beings are exposed to benzo[a] pyrene (BP) and other polycyclic hydrocarbon carcinogens in polluted city air/ o , 22 certain smoked and cooked foods,2, 9,15,16 and tobacco smoke. 3 , G, 11, 29, 30, 31 Since individuality in the metabolism of BP in…”

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confidence: 99%

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Comparison of the O‐dealkylation of 7‐ethoxycoumarin and the hydroxylation of benzo [a] pyrene in human placenta

Jacobson

Levin

Poppers

et al. 1974

Clin Pharma and Therapeutics

101

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A highly sensitive method is described for measuring the in vitro metabolism of 7-ethoxycoumarin or coumarin to 7-hydroxycoumarin. This method was used to measure the O-dealkylation of 7-ethoxycoumarin and the hydroxylation of coumarin by placentas from 12 nonsmokers or from 12 women who smoked cigarettes. Although an induced level of benzo[a]pyrene (BP) hydroxylase activity was found in each placenta obtained from women who smoked cigarettes during pregnancy, 7-ethoxycoumarin O-dealkylase activity was induced (about 2 fold) only in placentas whose BP hydroxylase activity was markedly induced (50 to 100 fold). These results indicate that ethoxycoumarin dealkylase activity parallels BP hydroxylase activity in human placenta only in individuals with markedly induced BP hydroxylase activity. No detectable hydroxylation of coumarin in the 7-position was observed in placental homogenates from nonsmokers 0., from women who smoked cigarettes.Human beings are exposed to benzo[a] pyrene (BP) and other polycyclic hydrocarbon carcinogens in polluted city air/ o , 22 certain smoked and cooked foods,2, 9, 15, 16 and tobacco smoke. 3 , G, 11, 29, 30, 31 Since individuality in the metabolism of BP in

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confidence: 99%

“…Human beings are exposed to benzo[a] pyrene (BP) and other polycyclic hydrocarbon carcinogens in polluted city air/ o , 22 certain smoked and cooked foods,2, 9,15,16 and tobacco smoke. 3 , G, 11, 29, 30, 31 Since individuality in the metabolism of BP in…”

mentioning

confidence: 99%

Comparison of the O‐dealkylation of 7‐ethoxycoumarin and the hydroxylation of benzo [a] pyrene in human placenta

Jacobson

Levin

Poppers

et al. 1974

Clin Pharma and Therapeutics

101

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“…Results presented in this paper show that cytochromes P-450 and b 5 are present in human liver and have spectral characteristics similar to those already reported in animals. In addition, studies are presented that describe the kinetic properties of a hydroxylase in human liver which metabolizes 3,4-benzpyrene, an environmental carcinogen present in polluted city air, 9 certain smoked and cooked foods, 8 and tobacco smoke. 4 …”

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confidence: 99%

Cytochromes P‐450 and bs in human liver microsomes

Alvares

Schilling

Levin

et al. 1969

Clin Pharma and Therapeutics

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Gastroenterologic Response to Environmental Agents — Absorption and Interactions

Pfeiffer

1977

Comprehensive Physiology

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The sections in this article are: General Principles of Interaction Between Environmental Agents and the Gut Mucosa Morphological Considerations General and Selected Physicochemical Principles Enteric Absorption and Mucosal Effects of Trace Elements Lead Nickel and Tin Mercury‐Containing Compounds Zinc and Cadmium Copper and Molybdenum Selenium Fluorine and Other Halogens Miscellaneous Trace Elements Mucosal Effects of Chemicals and Corrosives Gastrointestinal Absorption of Pesticides Absorption and Enteric Surface Effects of Miscellaneous Industrial Agents Polychlorinated Biphenyls and Triphenyls Polyglycerol Esters Organic Sulfonates and Other Surface‐Active Agents Dimethylsulfoxide Polyvinylchloride Stabilizers and Plasticizers Absorption and Enteric Surface Effects of Natural Environmental Contaminants Tannic Acid Miscellaneous Natural Compounds Ingestion of Carcinogenic Agents

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Carcinogens formed in the Heating of Foodstuffs. Formation of 3,4-Benzopyrene from Starch at 370-390° C

Cited by 16 publications

References 5 publications

Comparison of the O‐dealkylation of 7‐ethoxycoumarin and the hydroxylation of benzo [a] pyrene in human placenta

Comparison of the O‐dealkylation of 7‐ethoxycoumarin and the hydroxylation of benzo [a] pyrene in human placenta

Cytochromes P‐450 and bs in human liver microsomes

Gastroenterologic Response to Environmental Agents — Absorption and Interactions

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