Carcinogenicity testing in the CD-1 mouse of a prospective insect repellant (KBR 3023) using the dermal route of exposure

Temporal concentration changes of DEET, TCEP, terbutryn, and nonylphenols in freshwater streams of Hesse, Germany: possible influence of mandatory regulations and voluntary environmental agreements

“…In 1999, the Bayer group substituted the active agent in their products. For example, in the insect repellent Autan®, DEET was replaced by Bayrepel (1-piperidine carboxylic acid-2-(2-hydroxyethyl)-1-methylpropyl ester), which is as efficient as DEET and has no known adverse effects (Wahle et al 1999). However, there are still products on the market containing DEET as the active agent.…”

Toxicology and Safety Evaluation of the New Insect Repellent Picaridin (Saltidin)

“…In an oncogenicity study (Wahle et al, 1999a), Picaridin was administered dermally on the dorsal aspect of the trunk to 50 CD-1 mice/sex/dose at dose levels of 0, 50, 100, or 200 mg/kg/day on 5 consecutive days/week for 18 months. No toxicity or evidence of an oncogenic potential was observed at any dose level, up to and including the HDT of 200 mg/kg/day.…”