Carcinogenicity of sodium dichromate and chromium (VI/III)oxide aerosols inhaled by male wistar rats☆

Glaser, U.; Hochrainer, D.; Klöppel, H.; Oldiges, H.

doi:10.1016/0300-483x(86)90011-9

Cited by 61 publications

(26 citation statements)

References 15 publications

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“…The most recent studies indicate that, in a cell culture system, stable chromium(III) complexes are formed with cysteine, glutamic acid, histidine or glutathione [>50% of the chromium(II) bound to DNA]. Adducts with proteins are also known to be formed in such systems, especially with the acidic nuclear protein actin (18).…”

Section: Cross-linking Of Chromium and Dnamentioning

confidence: 99%

The chemistry underlying chromate toxicity

O’Brien

Kortenkamp

1995

Transition Met Chem

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Section: Cross-linking Of Chromium and Dnamentioning

confidence: 99%

The chemistry underlying chromate toxicity

O’Brien

Kortenkamp

1995

Transition Met Chem

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“…It is not clear whether the route of V administration or V toxicity itself was responsible for the differences between previously reported vanadate clearance results and those observed in this study. It has been shown previously that normal clearance of inhaled particles can be overwhelmed if particle exposure is continuous or if the particles themselves cause a progressive toxicity that alters the cell (i.e., M0) capacity to ingest/process particles (Glaser et al, 1985(Glaser et al, , 1986); a similar mechanism may underlie the reduced vanadate clearance observed in this study.…”

Section: Discussionmentioning

confidence: 45%

Pulmonary Immunotoxicity of Inhaled Ammonium Metavanadate in Fisher 344 Rats

et al. 1996

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Male Fisher 344 rats were exposed to 2 mg vanadium(V)/m 3 (as ammonium metavanadate NFL,VO 3 , 0.32 ^m MMD) atmospheres for 8 hr/day for 4 days in a nose-only exposure system. In exposed rats, lung V burdens increased in a time-dependent fashion. Analysis of lung cells and lavage fluid 24 hr after the final exposure suggested that tissue damage and a strong inflammatory response was elicited; numbers of neutrophil and small macrophages (Me), as well as levels of lavageable protein and lactate dehydrogenase, were significantly elevated as compared with levels observed with air-exposed rats. Vanadium also affected pulmonary alveolar M0 (PAM) capacities to produce and respond to immunoregulating cytokines. Inducible PAM production of tumor necrosis factor-a was significantly Inhibited, as was the ability to increase cell surface Class II/I-A molecule expression in response to interferon-? (LFN-)'). PAM from V-exposed hosts were also inhibited in their ability to be primed by EFN-y to produce superoride anion and hydrogen peroxide in response to stimulation with opsonized zymosan. These studies indicate that short-term repeated exposure of rats to atmospheric V, at levels encountered in an occupational setting, can alter host pulmonary immunomocompetence, with one major effect occurring at the level of cytokine-related functions. These alterations may be underlying mechanisms for the welldocumented increases in bronchopulmonary infections and cancers in workers chronically exposed to V-containing atmospheres.O 1996 Society of Toxicology.Vanadium (V), a Group Vb transition metal, is used widely in the steel and chemical industries, and is a constituent of many ores, coals, and oils (ATSDR, 1991). Increased mining and milling of V-bearing ores and combustion of fossil fuels for heating/energy production result in high levels of respirable V particles/fumes (containing both insoluble vanadium pentoxide and soluble vanadates) in many work environs (Nriagu and Pacyna, 1988; ATSDR, 1991). Ambient V levels in these settings can reach >30 mg/m 3 ; the ' To whom correspondence should be addressed. Fax: (914) 351-5472.

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“…Wyniki badań długotrwałego inhalacyjnego narażenia szczurów i myszy na związki Cr(VI) dostarczyły danych niezbędnych do oceny działania rakotwórczego i do ekstrapolacji danych ilościowych z wyników badań na zwierzętach na narażenie zawodowe ludzi [40][41][42]. Również badania na zwierzętach narażanych innymi drogami niż inhalacyjna dostarczyły pozytywnych wyników dotyczących rakotwórczego działania niektórych związków Cr(VI) [43].…”

Section: Działanie Związków Chromu(vi) Na Ludziunclassified

Occupational exposure to chromium(VI) compounds

Skowroń¹,

Konieczko²

2015

Med Pr

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StreszczenieW artykule omówiono wpływ związków chromu(VI) (Cr(VI)) na zdrowie człowieka w warunkach ostrego i przewlekłego narażenia w środowisku pracy. Związki chromu(VI) jako substancje rakotwórcze i mutagenne są zagrożeniem dla życia osób narażonych na ich działanie. Jeżeli nie można ich wyeliminować ze środowiska pracy i życia, narażenie na nie należy ograniczyć do minimum. Zaproponowana w Unii Europejskiej wartość wiążąca dopuszczalnego stężenia chromu(VI) w środowisku pracy (binding occupational exposure limits -BOELV), wynosząca 0,025 mg/m³, jest nadal związana z dużym ryzykiem wystą-pienia choroby nowotworowej u osób narażonych. Zgodnie z rekomendacją Komitetu Naukowego ds. Dopuszczalnych Norm Zawodowego Narażenia na Oddziaływanie Czynników Chemicznych (Scientific Commitee of Occupational Exposure Limits -SCOEL) narażenie na Cr(VI) o stężeniu 0,025 mg/m³ wiąże się ze wzrostem liczby przypadków raka płuc u 2-14 pracowników na 1000 osób narażonych. Narażenie pracowników na związki chromu(VI) (w przeliczeniu na Cr(VI)) na poziomie 0,01 mg Cr(VI)/m 3 jest związane ze wzrostem przypadków raka płuca u 1-6 pracowników wśród 1000 osób zatrudnionych w narażeniu na Cr(VI) o tym stężeniu przez cały okres aktywności zawodowej. Med. Pr. 2015;66(3):407-427 Słowa kluczowe: narażenie zawodowe, wartości dopuszczalnych stężeń, ocena ryzyka, związki chromu(VI), rakotwórczość AbstractThis article discusses the effect of chromium(VI) (Cr(VI)) on human health under conditions of acute and chronic exposure in the workplace. Chromium(VI) compounds as carcinogens and/or mutagens pose a direct danger to people exposed to them. If carcinogens cannot be eliminated from the work and living environments, their exposure should be reduced to a minimum. In the European Union the proposed binding occupational exposure limit value (BOELV) for chromium(VI) of 0.025 mg/m³ is still associated with high cancer risk. Based on the Scientific Commitee of Occupational Exposure Limits (SCOEL) document chromium(VI) concentrations at 0.025 mg/m³ increases the risk of lung cancer in 2-14 cases per 1000 exposed workers. Exposure to chromium(VI) compounds expressed in Cr(VI) of 0.01 mg Cr(VI)/m 3 is responsible for the increased number of lung cancer cases in 1-6 per 1000 people employed in this condition for the whole period of professional activity. Med Pr 2015;66(3):407-427

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Carcinogenicity of sodium dichromate and chromium (VI/III)oxide aerosols inhaled by male wistar rats☆

Cited by 61 publications

References 15 publications

The chemistry underlying chromate toxicity

The chemistry underlying chromate toxicity

Pulmonary Immunotoxicity of Inhaled Ammonium Metavanadate in Fisher 344 Rats

Occupational exposure to chromium(VI) compounds

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