Carcinogenicity of policosanol in sprague dawley rats: A 24 month study

Alemán, Celia; Ferreiro, Rosa Más; Puig, Miriam Noa; Guerra, Idania Rodeiro; Ortega, Caridad Hernández; Capote, Amelia

doi:10.1002/tcm.1770140505

Cited by 66 publications

(33 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the range and breadth of actions of Metadichol the results suggest that it mimics the effects of 1,25-dihydroxy Vitamin D3 but without the toxic effect secondary to Calcemia that has its use as a pharmaceutical agent [30]. Metadichol is the first example of a smart molecule that can simultaneously modulate multiple targets which can with Metadichol can lead potentially to a successful treatment of many of these challenging diseases [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Osteoporosis: A Case Study

Raghavan¹

2017

J Arthritis

View full text Add to dashboard Cite

Metadichol ® is a Nano emulsion of long-chain alcohols called as Policosanol and is present in foods such as rice, sugar cane, wheat, and peanuts. Metadichol ® acts on Nuclear Vitamin D receptors (VDR) that are present in cells throughout the body to stimulate the immune system and inhibit a variety of disease processes, resulting from inflammation to infection [1].We present a case study of a patient with Rheumatoid arthritis with the high levels of RF antibodies, CRP and ESR levels, and low bone mineral density leading to osteoporosis. The case report shows how Metadichol ® by its actions on the VDR has affected key biomarkers and mitigated the disease conditions without any side effects. Also, his bone density improved dramatically.Metadichol ® is safe because it consists of natural components of conventional foods and has no known adverse side effects. Its constituents are present in many foods that we consume every day.Metadichol ® has the potential to serve as a novel, safe solution to help patients with RA and other autoimmune diseases that confront the world today.

show abstract

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Osteoporosis: A Case Study

Raghavan¹

2017

J Arthritis

View full text Add to dashboard Cite

show abstract

“…All the three patients have shown improvements in various biomarkers like Creatinine, PTH, and ferritin and will be reported in due course. No adverse side effects have since Metadichol® is a natural food-based product that is completely safe [18][19].…”

Section: Discussionmentioning

confidence: 99%

“…Metadichol has the potential to be an anti-inflammatory molecule with a broad spectrum of activity. Its constituents (long-chain lipid alcohols) are present in foods commonly consumed on a daily basis and with no toxicity seen even with doses of up to 5000 mg/kg [18][19]. Metadichol could be used as a nutritional…”

Section: Discussionmentioning

confidence: 99%

Metadichol® and Red Cell Distribution Width (RDW) in CKD patients

PR¹

2017

J Stem Cell Res Ther

View full text Add to dashboard Cite

“…Figure 20 shows how Metadichol by acting on Nuclear receptors VDR, AHR, and ROR gamma is operating through multiple pathways to block TH17, TH1, IL17, IL22 and IL 23 pathways and thus enhancing anti-inflammatory pathways leading to resolution of psoriasis and related skin diseases. with a safe product like Metadichol [36,37,38]. Based on the experimental finding of Metadichol binding to the receptors that have a role in Psoriasis a software program like Topp Cluster [39,40] show that these clusters of genes target many skin related disease as shown in Figure 21.…”

Section: Metadichol Inverse Agonist Activity Against Ahrmentioning

confidence: 99%

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

PR¹

2017

J Clin Exp Dermatol Res

View full text Add to dashboard Cite

Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn's disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune systemsuppressing medications such as methotrexate.The T cells responsible for psoriasis are Th1 and Th l7 cells. IL-22, produced by Th17 cells, is crucial for the proliferation of keratinocytes. IL-22 with the help of IL-17 can induce the critical events of psoriasis. To maintain Th17 cells, IL-23 is required, and it is released from tumor necrosis factor-alpha (TNF-alpha) induced pathways. The pathophysiology of psoriasis involves RORC (retinoic acid receptor-related orphan nuclear receptor gamma) as a critical transcription factor for the development of Th17 cells. FDA has approved an antibody Secukinumab ® targeting TNF-α for the treatment of psoriasis. Other FDA approved drugs are Tremfya ® targeting IL23 for treatment of moderate to severe plaque psoriasis and Taltz ® that blocks IL17 for treatment of plaque psoriasis.Metadichol ® a nanoformulation of long-chain lipid alcohols derived from food is a TNF-alpha inhibitor and also binds to Vitamin D receptor (VDR) that could have beneficial effects on Psoriasis. VDR modulates Th1-mediated inflammatory disease like psoriasis. We now present evidence that Metadichol is an inverse agonist of RORγt and AHR (Aryl Hydrocarbon Receptor) thus controlling Th17, IL17 and IL22. Being a TNF-alpha inhibitor, it can control IL23 thus blocking the significant pathways that exacerbate psoriasis. We present case studies of 7 patients afflicted with psoriasis and skin related conditions and how treatment with Metadichol resolved the underlying disease. Metadichol ® has properties that allow its use as a safe nontoxic, toxic solution to combating the growing number of psoriasis cases. TNF-a is implicated in the pathogenesis of multiple inflammatory and autoimmune conditions such as like Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. The development of TNF-α inhibitors has improved therapeutic options for patients with these conditions. However, TNF-α inhibitors are paradoxically inducing the new onset of psoriasis or worsening preexisting quiescent psoriatic diseases [13].Genomic effects of 1, 25(OH)2D3 are controlled via binding to a nuclear receptor protein, VDR (vitamin D receptor). VDR is expressed in keratinocytes, fibroblasts, Langerhans cells, sebaceous gland cells, endothelial cells and almost the entire cell types related to the skin immune system [14]. Vitamin D and analogs display in the skin effects on cellular differentiation, proliferation, regulate psoriasis and represent a standard therapy. However, there is a need for highly antiproliferative or anti-inflammatory acting vitamin D analogs that exhibit only minor calcemic activity. Selective vitamin D signaling pathways that exert little calcemic activity would...

show abstract

Carcinogenicity of policosanol in sprague dawley rats: A 24 month study

Cited by 66 publications

References 10 publications

Rheumatoid Arthritis and Osteoporosis: A Case Study

Rheumatoid Arthritis and Osteoporosis: A Case Study

Metadichol® and Red Cell Distribution Width (RDW) in CKD patients

Metadichol, A Novel ROR Gamma Inverse Agonist and Its Applications in Psoriasis

Contact Info

Product

Resources

About