Carcinogenicity of cobalt, antimony compounds, and weapons-grade tungsten alloy

Wang, Amy; Dorman, David C.; Hall, Amy Laura; Pi, Jingbo; Sergi, Consolato; Symanski, Elaine; Ward, Elizabeth M.; Arrandale, Victoria H; Azuma, Kenichi; Brambila, Eduardo; Calaf, Gloria M.; Fritz, Jason M.; Fukushima, Shoji; Gaitens, Joanna M.; Grimsrud, Tom Kristian; Lynge, Elsebeth; Marinho-Reis, Amélia P; McDiarmid, Melissa A.; Middleton, Daniel; Ong, Thomas P; Polya, David A.; Quintanilla‐Vega, Betzabet; Roberts, Georgia; Santonen, Tiina; Sauni, Riitta; Silva, Maria João; Wild, Pascal; Zhang, Changwen W; Zhang, Qunwei; Grosse, Yann; Benbrahim‐Tallaa, Lamia; Conti, Aline de; DeBono, Nathan L; Ghissassi, Fatiha El; Madia, Federica; Reisfeld, Brad; Stayner, Leslie T.; Suonio, Eero; Viegas, Susana; Wedekind, Roland; Ahmadi, Shukrullah; Mattock, Heidi; Gwinn, William M.; Schubauer‐Berigan, Mary K.

doi:10.1016/s1470-2045(22)00219-4

Cited by 25 publications

(5 citation statements)

References 5 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like Pb, Sb is toxic [ 36 ], and the combination of the two metals represents a significant pollution hazard. In 2022, the International Agency for Research on Cancer (IARC) classified Sb(III) as probably carcinogenic to humans (Group 2A) [ 37 ]. Geologically, Sb often occurs together with As and has many coincident properties.…”

Section: Discussionmentioning

confidence: 99%

Ammunition Waste Pollution and Preliminary Assessment of Risks to Child Health from Toxic Metals at the Greek Refugee Camp Mavrovouni

Brubakk

Gjengedal

Enger

et al. 2022

IJERPH

View full text Add to dashboard Cite

The Mavrovouni refugee camp near the former Moria camp on the island of Lesvos, Greece, housed approximately 3000 asylum-seekers including children as of October 2021. The camp was built on the site of a military shooting range. This study aimed to characterize the soil contaminants and assess the risk of toxic environmental exposures for children living in Mavrovouni. Methods: Samples of surface soil (0–2 cm depth; particle size < 2 mm) from eight locations inside the camp were compared with two reference samples. Soil samples were microwave digested using a mixture of nitric and hydrofluoric acids and analyzed for lead (Pb), antimony (Sb), bismuth (Bi), and other metals using inductively coupled plasma mass spectrometry. These values were compared with action limits established by the Norwegian Environment Agency for kindergartens, playgrounds, and schools. Findings: Five of eight soil samples from inside the camp exceeded Pb levels of 100 mg/kg, which is currently the maximum acceptable value of Pb in soil for playgrounds in Norway. Two sites had extreme soil Pb levels of approximately 8000 mg/kg and 6000 mg/kg. The concen-tration of Sb and Bi in the surface soil of the firing range area strongly indicated environmental contamination, most likely from previous military activity and ammunition residue that has re-mained on the surface soil. Concentrations of arsenic (As), cadmium (Cd), copper (Cu), and zinc (Zn) in surface soil were lower than action limits. Discussion: Extremely high levels of Pb, together with high levels of Sb and Bi, were identified in soil where children live and play in the Mavrovouni refugee camp. This is the first independent study of environmental contamination at this camp and adds to the limited evidence base documenting Pb exposures prior to migrant and refugee reset-tlement. On top of the multiple existing public health crises and traumas that these asylum-seeking families face, exposure to toxic ammunition residues may have profound impacts on children’s development and health for years to come.

show abstract

Section: Discussionmentioning

confidence: 99%

Ammunition Waste Pollution and Preliminary Assessment of Risks to Child Health from Toxic Metals at the Greek Refugee Camp Mavrovouni

Brubakk

Gjengedal

Enger

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Regulatory organizations worldwide have established permissible concentrations for total Sb in drinking water (e.g., 10 µg/L in Europe [8]), yet specific regulations for Sb(III) and Sb(V) species are lacking, despite Sb(III) being recognized as ten times more toxic than Sb(V) [1,9]. Also, Sb(III) has been categorized as likely carcinogenic to humans by the International Agency for Research on Cancer of the World Health Organization, while Sb(V) cannot be classified in regard to its carcinogenicity [10,11]. Particularly concerning is the migration of Sb species in mineral water from polyethylene terephthalate (PET) materials, such as drinking water bottles [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Antimony Speciation Analysis via Frontal Chromatography–ICP-MS to Explore the Release of PET Additives

López,

Binda,

Roncoroni

et al. 2024

Molecules

View full text Add to dashboard Cite

Antimony (Sb) contamination poses significant environmental and health concerns due to its toxic nature and widespread presence, largely from anthropogenic activities. This study addresses the urgent need for an accurate speciation analysis of Sb, particularly in water sources, emphasizing its migration from polyethylene terephthalate (PET) plastic materials. Current methodologies primarily focus on total Sb content, leaving a critical knowledge gap for its speciation. Here, we present a novel analytical approach utilizing frontal chromatography coupled with inductively coupled plasma mass spectrometry (FC-ICP-MS) for the rapid speciation analysis of Sb(III) and Sb(V) in water. Systematic optimization of the FC-ICP-MS method was achieved through multivariate data analysis, resulting in a remarkably short analysis time of 150 s with a limit of detection below 1 ng kg−1. The optimized method was then applied to characterize PET leaching, revealing a marked effect of the plastic aging and manufacturing process not only on the total amount of Sb released but also on the nature of leached Sb species. This evidence demonstrates the effectiveness of the FC-ICP-MS approach in addressing such an environmental concern, benchmarking a new standard for Sb speciation analysis in consideration of its simplicity, cost effectiveness, greenness, and broad applicability in environmental and health monitoring.

show abstract

“…Human exposure to cobalt and chromium can occur for a short time or by prolonged exposure through inhalation, ingestion, or skin contact [4,5]. In human primary cells and experimental systems, cobalt metal seems to induce oxidative stress, chronic inflammation, changes in cell proliferation and death [6]; cobalt metal has also recently been classified as a C1B, M2, and R1B substance by the EU REACH Regulation, which has a significant and a direct impact on the application of Co-Cr biomedical alloys [7,8], despite the fact that metal cobalt presents physicochemical properties different from Co-based biomedical alloys [9].…”

Section: Introductionmentioning

confidence: 99%

Transport Properties of Carbohydrates: Towards the Minimization Toxicological Risks of Cobalt and Chromium Ions

et al. 2023

View full text Add to dashboard Cite

The influence of oligosaccharides (α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin), and a polysaccharide, sodium hyaluronate (NaHy), on the diffusion of aqueous solutions of cobalt and chromium chlorides has been investigated. Cobalt and chromium are constituents of metal alloys for biomedical use, including dental prostheses. Thus, the release of these ions in the human body can lead to harmful biological effects. The interaction of metal ions with saccharides might have information on the role of mouthwashes in preventing these effects. This interaction has been assessed by measuring multicomponent intermolecular diffusion coefficients at 298.15 K. It has been found that β-cyclodextrin has the highest interaction towards cobalt and chromium ions. This work will contribute to unveiling the mechanisms responsible for transport by diffusion in aqueous solutions, and, therefore, mitigating the potential toxicity inherent to those metal ions.

show abstract

Carcinogenicity of cobalt, antimony compounds, and weapons-grade tungsten alloy

Cited by 25 publications

References 5 publications

Ammunition Waste Pollution and Preliminary Assessment of Risks to Child Health from Toxic Metals at the Greek Refugee Camp Mavrovouni

Ammunition Waste Pollution and Preliminary Assessment of Risks to Child Health from Toxic Metals at the Greek Refugee Camp Mavrovouni

Optimizing Antimony Speciation Analysis via Frontal Chromatography–ICP-MS to Explore the Release of PET Additives

Transport Properties of Carbohydrates: Towards the Minimization Toxicological Risks of Cobalt and Chromium Ions

Contact Info

Product

Resources

About