Carcinogenicity of alcoholic beverages

Baan, R.A.; Straif, Kurt; Grosse, Yann; Secretan, Béatrice; Ghissassi, Fatiha El; Bouvard, Véronique; Altieri, Andrea; Cogliano, Vincent

doi:10.1016/s1470-2045(07)70099-2

Cited by 743 publications

(548 citation statements)

References 16 publications

Supporting

Mentioning

511

Contrasting

Unclassified

Order By: Relevance

“…In the West, alcohol intake is associated with a dose -response increase in ESCC risk, and heavy consumption increases risk by 5 -15-fold (Tuyns, 1983;Boffetta and Garfinkel, 1990;Brown et al, 1994;Baan et al, 2007). In our study, approximately 2% of cases and 2% of controls had ever regularly used alcohol, which was not significantly associated with ESCC risk.…”

Section: Discussioncontrasting

confidence: 59%

Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran

et al. 2008

View full text Add to dashboard Cite

The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in northeastern Iran was suggested by studies in the 1970s as partly due to opium use, which is not uncommon in this area, but based on limited numbers. From December 2003 to June 2007, we administered a validated structured questionnaire to 300 ESCC cases and 571 controls, matched on neighbourhood of residence, age (±2 years), and sex. We used conditional logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) adjusted for potential confounders. Compared with those who used neither tobacco nor opium, risk of ESCC was increased in those who used tobacco only (OR, 95% CI: 1.70, 1.05 -2.73), in those who used opium only (2.12, 1.21 -3.74), and in those who used both tobacco and opium (2.35, 1.50 -3.67). All forms of tobacco use (cigarettes, hookah, and nass) were associated with higher ESCC risk. Similarly, use of both crude opium and other forms of opium were associated with higher risk. Alcohol consumption was seen in only 2% of the cases and 2% of the controls, and was not associated with ESCC risk.

show abstract

Section: Discussioncontrasting

confidence: 59%

Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Excess ethanol consumption has been classified as a human (group 1) carcinogen 5,6 ; however, the exact mechanisms by which ethanol induces HCC are unclear. In the current study, we show a significant correlation between hepatic CYP2E1 expression in ALD patients and the quantity of exocyclic etheno-adducts, DNA lesions in the human liver with known mutagenic and carcinogenic properties.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the International Agency for Research on Cancer has classified ethanol as a human (group 1) carcinogen, because it induces HCC (among other tumors) in animals and increases the risk for developing HCC in humans. 3,5,6 …”

Section: E Xcess Consumption Of Alcohol Is Widespread Inmentioning

confidence: 99%

Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease

et al. 2009

View full text Add to dashboard Cite

Oxidative stress is thought to play a major role in the pathogenesis of hepatocellular cancer (HCC), a frequent complication of alcoholic liver disease (ALD). However, the underlying mechanisms are poorly understood. In hepatocytes of ALD patients, we recently detected by immunohistochemistry significantly increased levels of carcinogenic etheno-DNA adducts that are formed by the reaction of the major lipid peroxidation product, 4-hydroxynonenal (4-HNE) with nucleobases. In the current study, we show that protein-bound 4-HNE and etheno-DNA adducts both strongly correlate with cytochrome P450 2E1 (CYP2E1) expression in patients with ALD (r ‫؍‬ 0.9, P < 0.01). Increased levels of etheno-DNA adducts were also detected in the liver of alcohol-fed lean ( E xcess consumption of alcohol is widespread inWestern countries and, in the United States, alcohol abuse affects approximately 18 million adults. 1 The consumption of more than 80 g ethanol per day for more than 10 years increases the risk for hepatocellular carcinoma (HCC) by approximately fivefold. 2 Worldwide, HCC is one of the most common malignant tumors, ranking as the seventh most prevalent in men and the ninth in women. The risk for HCC in decompensated alcohol-induced cirrhosis is approximately 1% to 2% per year. 2 Although the evolution of alcohol-related HCC involves several factors, 3,4 including the presence of cirrhosis, oxidative stress, disturbed DNA methylation, and defective retinoic acid signaling, the precise mechanisms at a molecular level by which alcohol causes HCC are poorly understood. Recently, the International Agency for Research on Cancer has classified ethanol as a human (group 1) carcinogen, because it induces HCC (among other tumors) in animals and increases the risk for developing HCC in humans. 3,5,6

show abstract

“…2,3 The International Agency for Research on Cancer (IARC) has declared ethanol (the active metabolite of alcohol consumption) a Group 1 carcinogen to humans 4 , and there is sufficient evidence to suggest a dose-risk relationship between alcohol and adverse health outcomes, especially for cancer [5][6][7][8][9] , with no evidence of a threshold effect. 2 Moreover, there does not seem to be any appreciable differences for…”

mentioning

confidence: 99%

Alcohol consumption and low-risk drinking guidelines among adults: a cross-sectional analysis from Alberta’s Tomorrow Project

Brenner

Haig

Poirier

et al. 2017

Health Promot Chronic Dis Prev Can

View full text Add to dashboard Cite

Introduction Moderate to heavy alcohol consumption is a risk factor for all-cause mortality and cancer incidence. Although cross-sectional data are available through national surveys, data on alcohol consumption in Alberta from a large prospective cohort were not previously available. The goal of these analyses was to characterize the levels of alcohol consumption among adults from the Alberta’s Tomorrow Project in the context of cancer prevention guidelines. Furthermore, we conducted analyses to examine the relationships between alcohol consumption and other high-risk or risk-related behaviours. Methods Between 2001 and 2009, 31 072 men and women aged 35 to 69 years were enrolled into Alberta’s Tomorrow Project, a large provincial cohort study. Data concerning alcohol consumption in the past 12 months were obtained from 26 842 participants who completed self-administered health and lifestyle questionnaires. We conducted cross-sectional analyses on daily alcohol consumption and cancer prevention guidelines for alcohol use in relation to sociodemographic factors. We also examined the combined prevalence of alcohol consumption and tobacco use, obesity and comorbidities. Results Approximately 14% of men and 12% of women reported alcohol consumption exceeding recommendations for cancer prevention. Higher alcohol consumption was reported in younger age groups, urban dwellers, those with higher incomes and those who consumed more red meat. Moreover, volume of daily alcohol consumption was positively associated with current tobacco use in both men and women. Overall, men were more likely to fall in the moderate and high-risk behavioural profiles and show higher daily alcohol consumption patterns compared to women. Conclusion Despite public health messages concerning the adverse impact of alcohol consumption, a sizeable proportion of Alberta’s Tomorrow Project participants consumed alcohol in excess of cancer prevention recommendations. Continued strategies to promote low-risk drinking among those who choose to drink could impact future chronic disease risk in this population.

show abstract

Carcinogenicity of alcoholic beverages

Cited by 743 publications

References 16 publications

Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran

Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran

Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease

Alcohol consumption and low-risk drinking guidelines among adults: a cross-sectional analysis from Alberta’s Tomorrow Project

Contact Info

Product

Resources

About