Carcinogenicity and Mechanisms of Persistent Organic Pollutants

Ludewig, Gabriele; Robertson, Larry W.; Glauert, Howard P.

doi:10.1002/9781118679654.ch4

Cited by 3 publications

(1 citation statement)

References 240 publications

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“…Halogenated persistent organic pollutants (POPs) are long-lived compounds that are present in our daily environment and of concern to human health [ 1 ]. The toxic properties of POPs are well documented and many are classified as carcinogenic (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) [ 2 ], polybrominated diphenyl ethers (PBDEs) [ 3 ], immunotoxic (e.g., perfluoroalkyl substances (PFASs) [ 4 ], or neurotoxic (e.g., BDE-47 [ 5 ], and may affect reproduction and development (e.g., PCB-118 [ 6 ], endosulfan [ 7 ]). Brominated and chlorinated POPs are hydrophobic [ 8 ] and accumulate mainly in lipid rich tissues, while perfluorinated compounds tend to show a higher affinity for plasma proteins [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

Davidsen

Lauvås

Myhre

et al. 2021

Reproductive Toxicology

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Highlights Mixtures of 29 halogenated POPs were reconstructed based on human blood levels. In vitro assays permitted to evaluate DNT effects in human iPSC-derived NSCs. POPs at human blood levels increased proliferating NSCs and decreased synapses. Mathematical modelling showed that synaptogenesis was the most sensitive DNT endpoint. Data support a possible link between POPs and neurodevelopmental disorders.

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Section: Introductionmentioning

confidence: 99%

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

Davidsen

Lauvås

Myhre

et al. 2021

Reproductive Toxicology

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3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells

Zhang

Flor

Ruíz

et al. 2020

Environ. Sci. Technol.

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3,3'-Dichlorobiphenyl (PCB 11) is a byproduct of industrial processes and detected in environmental samples. PCB 11 and its metabolites are present in human serum, and emerging evidence demonstrates that PCB 11 is a developmental neurotoxicant. However, little is known about the metabolism of PCB 11 in humans. Here we investigated the metabolism of PCB 11 and the associated metabolomics changes in HepG2 cells using untargeted high-resolution mass spectrometry. HepG2 cells were exposed for 24 h to PCB 11 in DMSO or DMSO alone. Cell culture media were analyzed with ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. Thirty different metabolites were formed by HepG2 cells exposed to 10 μM PCB 11, including monohydroxylated, dihydroxylated, hydroxylatedmethoxylated, and methoxylated-di-hydroxylated metabolites, and the corresponding sulfo and glucuronide conjugates. The methoxylated PCB metabolites were observed for the first time in a human-relevant model. 4-OH-PCB 11 (3,3'-dichlorobiphenyl-4-ol) and the corresponding catechol metabolite, 4,5-di-OH-PCB 11 (3',5-dichloro-3,4-dihydroxybiphenyl), were unambiguously

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Finkel, Johnson, and empirical elicitations of risk magnitudes

Shrader-Frechette

2024

Human and Ecological Risk Assessment: An International Journal

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Carcinogenicity and Mechanisms of Persistent Organic Pollutants

Cited by 3 publications

References 240 publications

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells

Finkel, Johnson, and empirical elicitations of risk magnitudes

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