Carcinogenic Properties of Wear Particles From Prostheses Made in Cobalt-Chromium Alloy

Heath, J. C.; Freeman, M. A. R.; Swanson, S. A. V.

doi:10.1016/s0140-6736(71)91162-7

Cited by 148 publications

(46 citation statements)

References 6 publications

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“…The importance of metal release from the implant is due to the risk of toxicity and of sensitivity to metals as a possible cause of Ioosening (Evans et al 1974, Elves et al 1975, Langlais et al 1980, Uchida et al 1980) and of carcinogenicity (Oppenheimer et al 1956, Heath et al 1971, Kazantzis 1981, Norseth 1981. Few long-term studies have been performed on the levels of metal ions in organic fluids of patients with orthopedic implants (Brown et al 1977, Pazzaglia et al 1983.…”

mentioning

confidence: 99%

Metal ions in body fluids after arthroplasty

Pazzaglia

Minoia

Gualtieri

et al. 1986

Acta Orthopaedica Scandinavica

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mentioning

confidence: 99%

Metal ions in body fluids after arthroplasty

Pazzaglia

Minoia

Gualtieri

et al. 1986

Acta Orthopaedica Scandinavica

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“…and cobalt has been shown to be carcinogenic in experimental animals (Heath et al 1971); however, there have been no published cases of sarcoma in man attributed to this cause. The best combination of currently available materials for joint replacement are considered to be cobalt-chromiummolybdenum alloy or stainless steel in conjunction with ultra high molecular weight polyethylene.…”

Section: Frictionmentioning

confidence: 99%

The Basic Requirements and Design Criteria for Total Joint Prostheses

Elloy

Wright

Cavendish

1976

Acta Orthopaedica Scandinavica

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“…While wear particles from surgical prostheses containing cobalt were found to be carcinogenic in the rat (9), there are no convincing reports of cancer arising in relation to such a surgical implant in man, even though raised blood and urinary cobalt levels have been observed in patients with vitallium prostheses. Again, no definitive epidemiological studies have been performed.…”

Section: Carcinogenic Effectsmentioning

confidence: 99%

“…About one year after a single injection of 20 mg cobalt oxide into rat thigh muscle, 50% of the injected group responded with sarcomas, but mice given doses twice as high did not develop any malignant tumors (8). Particles from surgical prostheses made from cobalt-chromium alloys have been shown to be carcinogenic to rat muscle (9,10). Sarcomata, both at the injection site and at distant sites have also been produced with multiple injections of a solution of cobalt chloride in physiological saline (11).…”

Section: Carcinogenic Effectsmentioning

confidence: 99%

Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis.

Kazantzis¹

1981

Environ Health Perspect

124

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The possible carcinogenicity of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium is reviewed, taking into account epidemiological data, the results of animal experimental studies, data on mutagenic effects and on other in vitro test systems. Of the great variety of occupations where exposure to one of these metals may occur, only haematite mining has been clearly shown to involve an increased human cancer risk. While the possibility that haematite might in some way act as a carcinogen has to be taken into consideration it is more likely that other carcinogens are responsible. Certain platinum coordination complexes are used in cancer chemotherapy, are mutagenic, and likely to be carcinogenic. Cobalt, its oxide and sulfide, certain lead salts, one organomanganese, and one organotitanium compound have been shown to have a limited carcinogenic effect in experimental animal studies, and except for titanium appear to be mutagenic. Certain mercury compounds are mutagenic but none have been shown to be carcinogenic. The presently available data are inadequate to assess the possible carcinogenicity of selenium compounds, but a few observations suggest that selenium may suppress the effect of other carcinogens administered to experimental animals and may even be associated with lower cancer mortality rates in man. Epidemiological observations are essential for the assessment of a human cancer risk, but the difficulty in collecting past exposure data in occupational groups and the complexity of multiple occupational exposures with changes over time, limits the usefulness of retrospective epidemiological studies.

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Carcinogenic Properties of Wear Particles From Prostheses Made in Cobalt-Chromium Alloy

Cited by 148 publications

References 6 publications

Metal ions in body fluids after arthroplasty

Metal ions in body fluids after arthroplasty

The Basic Requirements and Design Criteria for Total Joint Prostheses

Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis.

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